Interferon-Stimulated Gene-15 (<i>Isg15</i>) Expression Is Up-Regulated in the Mouse Uterus in Response to the Implanting Conceptus

Austin, Kathy J.; Bany, Brent M.; Belden, E. L.; Rempel, Lea A.; Cross, James C.; Hansen, Thomas

doi:10.1210/en.2002-0031

Cited by 87 publications

(79 citation statements)

References 41 publications

(52 reference statements)

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“…Irf1 mRNA was most abundant in uteri of rats treated with both E 2 and IFNA. In support of findings of Li et al (2001), Austin et al (2004) and Bany & Cross (2006) reported that mouse trophoblast giant cells express IFNA that, in turn, induced expression of ISG15 during the peri-implantation period.…”

Section: Ifns and Uterine Receptivity To Implantation In Rodentssupporting

confidence: 78%

Comparative aspects of implantation

Bazer

Spencer²,

Johnson³

et al. 2009

Reproduction

345

285

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Uterine receptivity to implantation of blastocysts in mammals includes hatching from zona pellucida, precontact with uterine luminal (LE) and superficial glandular (sGE) epithelia and orientation of blastocyst, apposition between trophectoderm and uterine LE and sGE, adhesion of trophectoderm to uterine LE/sGE, and, in some species, limited or extensive invasion into the endometrial stroma and induction of decidualization of stromal cells. These peri-implantation events are prerequisites for pregnancy recognition signaling, implantation, and placentation required for fetal-placental growth and development through the remainder of pregnancy. Although there is a range of strategies for implantation in mammals, a common feature is the requirement for progesterone (P 4 ) to downregulate expression of its receptors in uterine epithelia and P 4 prior to implantation events. P 4 then mediates its effects via growth factors expressed by stromal cells in most species; however, uterine luminal epithelium may express a growth factor in response to P 4 and/or estrogens in species with a true epitheliochorial placenta. There is also compelling evidence that uterine receptivity to implantation involves temporal and cell-specific expression of interferon (IFN)-stimulated genes that may be induced directly by an IFN or induced by P 4 and stimulated by an IFN. These genes have many roles including nutrient transport, cellular remodeling, angiogenesis and relaxation of vascular tissues, cell proliferation and migration, establishment of an antiviral state, and protection of conceptus tissues from challenges by the maternal immune cells.

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Section: Ifns and Uterine Receptivity To Implantation In Rodentssupporting

confidence: 78%

Comparative aspects of implantation

Bazer

Spencer²,

Johnson³

et al. 2009

Reproduction

345

285

View full text Add to dashboard Cite

show abstract

“…Although the IFN-τ are unique to the Ruminantia, a sub-order within the much larger Artiodactyla order, there are hints from transcriptional profiling experiments that a partial interferon-response occurs in humans and mice as the trophoblast makes intimate contact with the maternal endometrium and induces the formation of a deciduum, in which stromal fibroblast proliferate and form an edematous structure adjacent to the site of implantation (37)(38)(39). This response does not involve a full-blown up-regulation of many interferon-stimulated genes (ISGs), as noted in the sheep endometrium during early pregnancy (12,13,40), but is instead more limited.…”

Section: Type 1 Ifn and Pregnancymentioning

confidence: 99%

Interferon-tau, a Type 1 interferon involved in maternal recognition of pregnancy

Roberts

2007

Cytokine & Growth Factor Reviews

108

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Interferon-τ is a major product of ovine and bovine conceptuses during the period before the trophoblast makes firm attachment to the uterine wall and begins to form a placenta. Its primary function is in preventing a return to ovarian cyclicity and hence ensuring the pregnancy continues, although it undoubtedly has other roles in ensuring receptivity of the maternal endometrium. Despite having properties similar to those of other Type 1, IFN-τ is not virally inducible and functions in a constitutive process unrelated to pathogenesis. The genes for IFN-τ (IFNT), which are confined to ruminant ungulate species, would appear to be the most recently evolved mammalian Type 1 gene family and are primarily under the transcriptional control of Ets2 and signal transduction pathways that target that transcription factor. The IFNT provide an illustration of how a gene control region can be commandeered and then refined to provide a radically changed pattern of expression.

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“…Interferons (IFNA, IFNB, IFNG) are produced by placentae of mice as early as day 7 of pregnancy and several ISGs are expressed by cells in implantation sites (Austin et al, 2003;Bany and Cross, 2006). Expression of both IFNA and interferon-regulated gene 1 (IRG1) increase in uteri of pregnant rats between days 1 and 4 and then decrease following implantation.…”

Section: Pseudopregnancy and Pregnancymentioning

confidence: 99%

Pregnancy recognition signals in mammals: the roles of interferons and estrogens

Bazer

Johnson

2017

Anim Reprod

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Reproduction is a highly complex biological process requiring a dialogue between the developing conceptus (embryo-fetus and associated placental membranes) and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling and regulation of gene expression by uterine epithelial and stromal cells. The uterus provide a microenvironment in which molecules secreted by uterine epithelia or transported into the uterine lumen represent histotroph or the secretome required for growth and development of the conceptus and receptivity of the uterus to implantation by the conceptus. Pregnancy recognition signaling as related to sustaining the functional lifespan of the corpora lutea (CL) which produce progesterone; the hormone of pregnancy essential for uterine functions that support implantation and placentation required for successful outcomes of pregnancy. It is within the periimplantation period that most embryonic deaths occur in mammals due to deficiencies attributed to uterine functions or failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. The endocrine status of the pregnant female and her nutritional status are critical for successful establishment and maintenance of pregnancy. The challenge is to understand the complexity of key mechanisms that are characteristic of successful reproduction and to use that knowledge to enhance fertility and reproductive health of animals including nonhuman primates. It is important to translate knowledge gained from studies of animals to address issues of fertility and reproductive health in humans.

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Interferon-Stimulated Gene-15 (Isg15) Expression Is Up-Regulated in the Mouse Uterus in Response to the Implanting Conceptus

Cited by 87 publications

References 41 publications

Comparative aspects of implantation

Comparative aspects of implantation

Interferon-tau, a Type 1 interferon involved in maternal recognition of pregnancy

Pregnancy recognition signals in mammals: the roles of interferons and estrogens

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