Interferon signaling

Heim, Markus H.

doi:10.1002/9781118663387.ch16

Cited by 2 publications

(1 citation statement)

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“…A potential regulatory layer that remains poorly understood is the role of STAT1 and STAT3 heterodimers induced by IFNs. On one hand, STAT1 and STAT3 heterodimers have been described to bind regulatory elements present in promoters of interferon-stimulated genes (ISGs) such as γ-activated sequence (GAS), supporting a potential antiviral role of STAT1 and STAT3 heterodimers [ 61 ]. On the other hand, it has been proposed that STAT1 and STAT3 heterodimers can effectively quench STAT1 and thus provide negative feedback in a later phase of the IFN response [ 57 ].…”

Section: Physiological Role Of Stat3 In Inflammationmentioning

confidence: 99%

Viral manipulation of STAT3: Evade, exploit, and injure

et al. 2018

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Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous physiological functions, including the immune response. As pathogens elicit an acute phase response with concerted activation of STAT3, they are confronted with two evolutionary options: either curtail it or employ it. This has important consequences for the host, since abnormal STAT3 function is associated with cancer development and other diseases. This review provides a comprehensive outline of how human viruses cope with STAT3-mediated inflammation and how this affects the host. Finally, we discuss STAT3 as a potential target for antiviral therapy.

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Section: Physiological Role Of Stat3 In Inflammationmentioning

confidence: 99%

Viral manipulation of STAT3: Evade, exploit, and injure

et al. 2018

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Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection

Kim

Maharjan

Choi

et al. 2021

Biomol Ther (Seoul)

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Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Signaling pathways that are essential for virus production have potential as therapeutic targets against COVID-19. In this study, we investigated cellular responses in two cell lines, Vero and Calu-3, upon SARS-CoV-2 infection and evaluated the effects of pathway-specific inhibitors on virus production. SARS-CoV-2 infection induced dephosphorylation of STAT1 and STAT3, high virus production, and apoptosis in Vero cells. However, in Calu-3 cells, SARS-CoV-2 infection induced long-lasting phosphorylation of STAT1 and STAT3, low virus production, and no prominent apoptosis. Inhibitors that target STAT3 phosphorylation and dimerization reduced SARS-CoV-2 production in Calu-3 cells, but not in Vero cells. These results suggest a necessity to evaluate cellular consequences upon SARS-CoV-2 infection using various model cell lines to find out more appropriate cells recapitulating relevant responses to SARS-CoV-2 infection in vitro .

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Interferon signaling

Cited by 2 publications

References 122 publications

Viral manipulation of STAT3: Evade, exploit, and injure

Viral manipulation of STAT3: Evade, exploit, and injure

Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection

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