Interferon Regulatory Factor Family Genes: At the Crossroads between Immunity and Head and Neck Squamous Carcinoma

Liu, Shaokun; Wang, Zhenlin

doi:10.1155/2022/2561673

Cited by 5 publications

(7 citation statements)

References 37 publications

(39 reference statements)

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“…In the field of OSCC, IRF4 were highly expressed in OSCC tumor samples compared to control samples and involved in tumor immunity-related signaling pathways. IRF4 indicated significant prognostic values and could be potential therapeutic biomarkers in targeting tumor immunity of OSCC 51 .…”

Section: Discussionmentioning

confidence: 99%

“…

the oncogenic transcriptional program in malignant lymphoid cells 15 . However, research on the role of IRF4 in OSCC is still lacking 16 .In this study, we conducted a comprehensive bioinformatics analysis including functional enrichment analysis, CNV and immune infiltration analysis through Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases to identify key genes and explore the underlying molecular mechanisms involved in OSF into OSCC. We finally found the role of IRF4 in predictabilities of the transformation from OSF to the presence of OSCC.

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mentioning

confidence: 99%

“…the oncogenic transcriptional program in malignant lymphoid cells 15 . However, research on the role of IRF4 in OSCC is still lacking 16 .…”

mentioning

confidence: 99%

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IRF4 as a novel target involved in malignant transformation of oral submucous fibrosis into oral squamous cell carcinoma

Jiang

You

et al. 2023

Sci Rep

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Oral squamous cell carcinoma (OSCC) in the context of oral submucous fibrosis (OSF) has a high incidence owing to undefined pathogenesis. Identifying key genes and exploring the underlying molecular mechanisms involved in the conversion of OSF into OSCC are in urgent need. Differentially expressed genes (DEGs) between OSCC and OSF were dug from GEO databases and a total of 170 DEGs were acquired. Functional association of DEGs were analyzed by GO and KEGG. Protein–protein interactions (PPIs) analysis was carried out and candidate biomarkers were identified by Gene co-expression analysis and Cox analyses. Hub genes were confirmed by qRT-PCR in tissues and cell lines, of which we found that IRF4 mRNA was successively up-regulated from Normal to OSF and then to OSCC and associated with immune infiltrating levels. In addition, Immunohistochemical (IHC) and Immunofluorescence (IF) assays were conducted to validate the consistent upregulation of IRF4 and the oncogene role of IRF4 in OSF and OSCC at translation level. IRF4 may be indicative biomarker in transformation of OSF into OSCC. High IRF4 expression contribute to increased immune infiltration of OSCC and may provide a novel diagnostic marker for OSCC patients translated from OSF.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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IRF4 as a novel target involved in malignant transformation of oral submucous fibrosis into oral squamous cell carcinoma

Jiang

You

et al. 2023

Sci Rep

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“…Through bioinformatics analysis, we found that FSCN1 could interact with IRF4, which is involved in the oncogenesis of multiple cancers. For instance, IRF4 upregulation was correlated with survival outcomes in head and neck squamous carcinoma [ 33 ]. In cholangiocarcinoma, IRF4 promotes cancer proliferation as well as metastasis by regulating PI3K/AKT signaling [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

FSCN1 promotes proliferation, invasion and glycolysis via the IRF4/AKT signaling pathway in oral squamous cell carcinoma

Chen

et al. 2023

BMC Oral Health

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Background Oral squamous cell carcinoma (OSCC) is a disease with increasing incidence worldwide that leads to deformity and death. In OSCC, fascin actin-bundling protein 1 (FSCN1) is an oncogene involved in the tumorigenesis process. However, the functions and potential mechanisms of FSCN1 in the OSCC tumorigenesis process have not been reported thus far. Methods We used qRT‒PCR to detect the expression of FSCN1 in 40 paired OSCC tumor tissues (tumor) and neighboring noncancerous tissues. The role of FSCN1 was also assessed in vitro through colony formation, CCK-8, and transwell assays. Moreover, glucose consumption was detected. Western blotting was used to confirm the interaction of FSCN1, IRF4 and AKT. Results FSCN1 was remarkably overexpressed in OSCC tissues and cell lines compared to corresponding controls. In addition, colony formation, CCK-8, and transwell assays revealed a notable reduction in OSCC growth and invasion when FSCN1 was silenced. FSCN1 silencing remarkably suppressed OSCC glycolysis. Mechanistic studies showed that FSCN1 achieves its function partially by activating interferon regulatory factor 4 (IRF4) and the AKT pathway in OSCC. Conclusion In conclusion, our study investigated the functions and mechanisms of the FSCN1/IRF4/AKT pathway in OSCC progression. In OSCC, FSCN1 is likely to be a biomarker and therapeutic target.

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“…Through bioinformatics analysis, we found that FSCN1 could interact with IRF4, which is involved in multiple cancer oncogenesis. For instance, IRF4 upregulation was correlated with the survival outcomes in head and neck squamous carcinoma (33). In cholangiocarcinoma, IRF4 promotes cancer proliferation as well as metastasis via regulating the PI3K/AKT signaling (34).…”

Section: Discussionmentioning

confidence: 99%

FSCN1 promotes proliferation, migration and glycolysis via the IRF4/AKT signalling pathway in oral squamous cell carcinoma

Chen

et al. 2022

Preprint

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Background: Oral squamous cell carcinoma (OSCC) is an increasing disease worldwide that leads to lethal and deforming consequences. In OSCC, Fascin actin-bundling protein 1 (FSCN1) is identified as an oncogene involved in the tumorigenesis process. But the functions as well as potential mechanisms of FSCN1 in OSCC tumorigenesis process have not been reported so far. Methods: We used RNA sequencing to detect the expreesion of FSCN1 from 40 paired OSCC tissue specimens (Tumor) and neighboring noncancerous tissue. Further colony formation, CCK-8 as well as transwell assay was performed to demonstrate the role of FSCN1 in vitro. Moreover, glucose consumption was detected. Western blot was used to confirm the interaction of FSCN1, IRF4 and AKT. Results: FSCN1 was remarkably overexpressed in OSCC cell lines as well as tissues. Further colony formation, CCK-8 as well as transwell assay suggested that FSCN1 silencing remarkably dampened OSCC growth and migration. Detection of glycolytic metabolism showed that FSCN1 silence remarkably suppressed OSCC glycolysis. Following mechanism studies revealed that FSCN1 realized its functions in OSCC process partially through the interferon regulatory factor 4 (IRF4) and AKT activation. Conclusion: In conclusion, our study investigated the functions as well as the mechanisms of the FSCN1/IRF4/AKT pathway in OSCC progression. FSCN1 could act as a prospective biologic signature and therapeutic target molecule for OSCC.

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Interferon Regulatory Factor Family Genes: At the Crossroads between Immunity and Head and Neck Squamous Carcinoma

Cited by 5 publications

References 37 publications

IRF4 as a novel target involved in malignant transformation of oral submucous fibrosis into oral squamous cell carcinoma

IRF4 as a novel target involved in malignant transformation of oral submucous fibrosis into oral squamous cell carcinoma

FSCN1 promotes proliferation, invasion and glycolysis via the IRF4/AKT signaling pathway in oral squamous cell carcinoma

FSCN1 promotes proliferation, migration and glycolysis via the IRF4/AKT signalling pathway in oral squamous cell carcinoma

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