Interferon regulatory factor 7 in inflammation, cancer and infection

Qing, Furong; Liu, Zhiping

doi:10.3389/fimmu.2023.1190841

Cited by 35 publications

(17 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In line with Fasolino et al. ( 20 ) observations, we report that the duct-acinar subpopulation expresses, although at low levels, ICAM1, ISG20, and IRF7, which are essential for immune cell interaction and the promotion of inflammation ( 31 – 33 ).…”

Section: Discussionsupporting

confidence: 90%

Single-cell transcriptomics reveals a role for pancreatic duct cells as potential mediators of inflammation in diabetes mellitus

Muñoz García,

Juksar,

Groen

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

IntroductionInflammation of the pancreas contributes to the development of diabetes mellitus. Although it is well-accepted that local inflammation leads to a progressive loss of functional beta cell mass that eventually causes the onset of the disease, the development of islet inflammation remains unclear.MethodsHere, we used single-cell RNA sequencing to explore the cell type-specific molecular response of primary human pancreatic cells exposed to an inflammatory environment.ResultsWe identified a duct subpopulation presenting a unique proinflammatory signature among all pancreatic cell types.DiscussionOverall, the findings of this study point towards a role for duct cells in the propagation of islet inflammation, and in immune cell recruitment and activation, which are key steps in the pathophysiology of diabetes mellitus.

show abstract

Section: Discussionsupporting

confidence: 90%

Single-cell transcriptomics reveals a role for pancreatic duct cells as potential mediators of inflammation in diabetes mellitus

Muñoz García,

Juksar,

Groen

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…The regulatory factors interferon IRF1 and IRF7 are known to regulate the expression of interferons of the first (α and β) and second (γ) types, acting as inducers of inflammation in the development of tumor diseases [ 32 , 33 , 34 ]. STAT3 and STAT6 are also known to be activated during inflammation in the tumor microenvironment; their activity may be associated with an increased inflammatory response during leukemia progression [ 35 , 36 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

Studying Signaling Pathway Activation in TRAIL-Resistant Macrophage-Like Acute Myeloid Leukemia Cells

Lomovskaya,

Krasnov,

Kobyakova

et al. 2024

Acta Naturae

View full text Add to dashboard Cite

Acute myeloid leukemia (AML) is a malignant neoplasm characterized by extremely low curability and survival. The inflammatory microenvironment and maturation (differentiation) of AML cells induced by it contribute to the evasion of these cells from effectors of antitumor immunity. One of the key molecular effectors of immune surveillance, the cytokine TRAIL, is considered a promising platform for developing selective anticancer drugs. Previously, under in vitro conditions of the inflammatory microenvironment (a three-dimensional high-density culture of THP-1 AML cells), we demonstrated the emergence of differentiated macrophage-like THP-1ad clones resistant to TRAIL-induced death. In the present study, constitutive activation of proinflammatory signaling pathways, associated transcription factors, and increased expression of the anti-apoptotic BIRC3 gene were observed in TRAIL-resistant macrophage-like THP-1ad AML cells. For the first time, a bioinformatic analysis of the transcriptome revealed the main regulator, the IL1B gene, which triggers proinflammatory activation and induces resistance to TRAIL in THP–1ad macrophage-like cells.

show abstract

“…IRF7 is a lymphoid-specific factor that is predominantly expressed in the cytoplasm of the spleen, thymus and peripheral blood lymphocytes, such as B cells, plasmacytoid dendritic cells (pDCs) and monocytes ( Ma et al, 2023 ). Recent studies have revealed that IRF7 exerts a broad range of activities in different biological processes ( Qing and Liu, 2023 ). In this study, YP significantly reduced the mRNA level of IL-1β in jejunum and ileum compared with PEDV group, this is consistent with the study of No et al (2021) .…”

Section: Discussionmentioning

confidence: 99%

Effect of supplementation with yeast polysaccharides on intestinal function in piglets infected with porcine epidemic diarrhea virus

Li,

Wu,

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

Porcine epidemic diarrhea virus (PEDV) has caused huge economic losses to the pig industry. Yeast polysaccharides (YP) has been used as a feed additive in recent years and poses good anti-inflammatory and antiviral effects. The present study aimed to explore the protective effect of YP on intestinal damage in PEDV-infected piglets. Eighteen 7-day-old piglets with similar body weights were randomly divided into three groups: Control group (basal diet), PEDV group (basal diet), and PEDV+YP group (basal diet +20 mg/kg BW YP), six replicates per group and one pig per replicate. Piglets in PEDV group and PEDV+YP group were orally given PEDV (dose: 1 × 106 TCID50) at 19:30 PM on the 8th day of the experiment. The control group received the same volume of PBS solution. Weight was taken on an empty stomach in the morning of the 11th day, blood was collected and then anesthetic was administered with pentobarbital sodium (50 mg/kg·BW) by intramuscular injection, and samples were slaughtered after the anesthetic was complete. The results showed that YP could alleviate the destruction of intestinal villus morphology of piglets caused by PEDV. Meanwhile, PEDV infection can reduce the activity of glutathione peroxidase, superoxide dismutase and catalase, and increase the content of malondialdehyde. YP can improve the antioxidative capacity in the serum and small intestine of PEDV-infected piglets. In addition, YP inhibited the replication of PEDV in the jejunum ileum and colon. Moreover, YP can regulate the mRNA levels of inflammatory genes (IL-1β and iNOS) and lipid metabolic genes (APOA4 and APOC3) in the small intestine. In summary, YP could inhibit virus replicates, improve intestinal morphology, enhance antioxidant capacity, relieve inflammation and regulate the metabolism of the intestine in PEDV-infected piglets.

show abstract

Interferon regulatory factor 7 in inflammation, cancer and infection

Cited by 35 publications

References 60 publications

Single-cell transcriptomics reveals a role for pancreatic duct cells as potential mediators of inflammation in diabetes mellitus

Single-cell transcriptomics reveals a role for pancreatic duct cells as potential mediators of inflammation in diabetes mellitus

Studying Signaling Pathway Activation in TRAIL-Resistant Macrophage-Like Acute Myeloid Leukemia Cells

Effect of supplementation with yeast polysaccharides on intestinal function in piglets infected with porcine epidemic diarrhea virus

Contact Info

Product

Resources

About