Interferon Levels and Resistance to Viral Infection Associated with Selected Interferon Inducers

Chlorite-oxidized amylose (COAM), polyinosinic-polycytidylic acid [poly(I:C)], and combinations of the two drugs were evaluated for their interferon-inducing properties and their ability to protect mice against rabies infection. Post-exposure administration of one or two doses (100 μg each) of poly(I:C) significantly protected mice against rabies infection. Pretreatment of mice with COAM 3 h before poly(I:C) stimulation resulted in an enhancement of the interferon response. However, the increased interferon titers were not reflected by increased protection against rabies infection over that achieved with poly(I:C) therapy alone. Therapy with COAM alone did not protect mice against rabies but, rather, was associated with enhanced mortality.

Section: Resultssupporting

confidence: 82%

mentioning

confidence: 99%

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confidence: 99%

See 1 more Smart Citation

Post-Exposure Prophylaxis of Murine Rabies with Polyinosinic-Polycytidylic Acid and Chlorite-Oxidized Amylose

Harmon

Janis

Levy

1974

“…Endotoxin had no effect, whereas statolon treatment resulted in a shortening of the mean survival time. The relative mean survival rate, which gives an approximate but valuable 80 overall evaluation of protection by taking into account both mortality and mean survival time (4), indicates that, with the exception of statolon, there was a protective effect in each instance. Statolon treatment, however, enhanced infection.…”

mentioning

confidence: 99%

Effect of Interferon Inducers and Interferon on Bacterial Infections

Giron

Schmidt

Ball

et al. 1972

“…The Trinidad donkey strain of VEE virus was used in these studies (14). The virus was originally isolated in guinea pigs and has been maintained by 13 lactically to VEE virus-infected mice. R. W. Krueger and S. Yoshimura (Fed.…”

mentioning

confidence: 99%

Evaluation of Various Analogues of Tilorone Hydrochloride Against Venezuelan Equine Encephalitis Virus in Mice

Kuehne

Pannier

Stephen

1977

The antiviral activity of tilorone hydrochloride and three of its analogues (11,002, 11,567, and 11,877) was assessed by oral and intraperitoneal (i.p.) administration to Venezuelan equine encephalitis (VEE) virus-infected mice. Significant increases in the percentage of survival ( P < 0.01) were apparent after oral administration of tilorone and analogue 11,877 at dosages of 250 and 500 mg/kg. Neither tilorone nor 11,877 increased percentage of survival when dosages of 31.25 to 500 mg/kg were given by the i.p. route. Orally administered analogue 11,002 was effective against 100 mouse intracranial median lethal doses (MICLD 50 ) of VEE virus at doses at 250 to 1,000 mg/kg; doses of 31.25 to 250 mg/kg given i.p. were effective against 10 MICLD 50 . Oral dosages of 250 to 1,000 mg of analogue 11,567 per kg were active against 100 MICLD 50 of virus. By the i.p. route, 250 mg of 11,567 per kg protected mice against 1,000 MICLD 50 , and a dose of 125 mg/kg protected against 100 MICLD 50 . Oral treatment of VEE infection with analogue 11,567 24 h after subcutaneous inoculation of VEE virus resulted in no significant increase in the percentage of survivors. All survivors of these studies were susceptible to rechallenge 21 days after the first inoculation of virus.