Interferon-inducible lncRNA IRF1-AS represses esophageal squamous cell carcinoma by promoting interferon response

Huang, Jianbing; Li, Jiagen; Li, Yuan; Lu, Zhiliang; Cao, Yun; Mao, Shuangshuang; Lei, Yuanyuan; Zang, Ruochuan; Zheng, Sufei; Liu, Chengming; Wang, Xinfeng; Li, Ning; Sun, Nan; He, Jie

doi:10.1016/j.canlet.2019.05.038

Cited by 34 publications

(34 citation statements)

References 28 publications

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“…25 Antisense lncRNAs may positively or negatively regulate the sense gene via RNA-RNA interaction. 26,27 For example, PU.1 antisense lncRNA promotes adipogenesis through preventing PU.1 mRNA translation via binding to PU.1 mRNA to form mRNA-antisense lncRNA duplex in preadipocytes. 28 Here, our pull-down assay demonstrated that Gm5820 directly bind with its sense transcript FGF1 mRNA and form sense-antisense RNA duplex.…”

Section: Discussionmentioning

confidence: 99%

Retracted Article: Gm5820, an antisense RNA of FGF1, suppresses FGF1 expression at the posttranscriptional level to inactivate the ERK/STAT3 pathway and alleviates neuropathic pain in mice

Zhang

Ding

et al. 2019

RSC Adv.

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Section: Discussionmentioning

confidence: 99%

Retracted Article: Gm5820, an antisense RNA of FGF1, suppresses FGF1 expression at the posttranscriptional level to inactivate the ERK/STAT3 pathway and alleviates neuropathic pain in mice

Zhang

Ding

et al. 2019

RSC Adv.

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“…23,24 Our group was the first to establish a three-lncRNA signature as a powerful predictor of survival in patients with ESCC and performed extensive studies on the function of lncRNAs in ESCC progression. [25][26][27][28] What's more, recent studies have revealed the significant role of lncRNAs in ESCC chemoradiotherapy resistance. 29,30 indicating that lncRNAs may also play an in vitro role in nCRT.…”

Section: Introductionmentioning

confidence: 99%

A three‐lncRNA signature of pretreatment biopsies predicts pathological response and outcome in esophageal squamous cell carcinoma with neoadjuvant chemoradiotherapy

Zhang

et al. 2020

Clinical & Translational Med

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Background Current strategies are insufficient to predict pathologically complete response (pCR) for esophageal squamous cell carcinomas (ESCCs) before treatment. Here, we aim to develop a novel long noncoding RNA (lncRNA) signature for pCR and outcome prediction of ESCCs through a multicenter analysis for a Chinese population. Methods Differentially expressed lncRNAs (DELs) between pCRs and less than pCR (

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“…Long non-coding RNAs (lncRNAs) are a group of highly conserved transcripts of >200 nucleotides, with no protein coding ability (6)(7)(8). An increasing number of studies have documented the involvement of lncRNAs in regulating the biological behaviors of cancer cells (9,10).…”

Section: Introductionmentioning

confidence: 99%

LINC00473 contributes to the radioresistance of esophageal squamous cell carcinoma by regulating microRNA‑497‑5p and cell division cycle 25A

Liu

Qiao

et al. 2020

Int J Mol Med

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Long non-coding RNA (lncRNA) LINc00473 plays a carcinogenic role in a variety of different tumor types. Nevertheless, the mechanisms through which LINc00473 regulates the radiosensitivity of esophageal squamous cell carcinoma (EScc) cells remains elusive. In the present study, reverse transcription-quantitative PcR was used to quantify the expression of LINc00473, microRNA (miRNA/miR)-497-5p and cell division cycle 25A (cdc25A) in EScc tissues. The association between LINc00473 expression and the clinicopathological characteristics of patients with EScc was also assessed. Furthermore, cell counting kit-8 and colony formation assays were carried out to monitor the proliferation of EScc cells exposed to X-ray radiation. A dual-luciferase reporter assay was also conducted to analyze the interaction between LINc00473 and miR-497-5p, as well as the interaction between CDC25A and miR-497-5p. The findings of the present study demonstrated that in EScc tissues and cells, the expression levels of LINC00473 and CDC25A were significantly upregulated, while the expression of miR-497-5p was downregulated. The high expression level of LINc00473 was associated with a higher T stage, lymph node metastasis stage and a lower tumor differentiation grade in patients with EScc. Following irradiation, transfection with miR-497-5p mimics reduced the promoting effect of LINc00473 overexpression on EScc cell proliferation, and partially impeded the resistance of EScc cells to X-ray radiation induced by LINc00473 overexpression. Moreover, transfection with miR-497-5p inhibitors partially alleviated the inhibitory effects of LINc00473 knockdown on cellular proliferation, and partly reversed the sensitivity of cells to X-ray irradiation induced by LINc00473 knockdown. Furthermore, it was confirmed that miR-497-5p was able to bind LINc00473 and the 3'-untranslated region of CDC25A. On the whole, the findings of the present study demonstrate that LINc00473 reduces the radiosensitivity of EScc cells by modulating the miR-497-5p/cdc25A axis.

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Interferon-inducible lncRNA IRF1-AS represses esophageal squamous cell carcinoma by promoting interferon response

Cited by 34 publications

References 28 publications

Retracted Article: Gm5820, an antisense RNA of FGF1, suppresses FGF1 expression at the posttranscriptional level to inactivate the ERK/STAT3 pathway and alleviates neuropathic pain in mice

Retracted Article: Gm5820, an antisense RNA of FGF1, suppresses FGF1 expression at the posttranscriptional level to inactivate the ERK/STAT3 pathway and alleviates neuropathic pain in mice

A three‐lncRNA signature of pretreatment biopsies predicts pathological response and outcome in esophageal squamous cell carcinoma with neoadjuvant chemoradiotherapy

LINC00473 contributes to the radioresistance of esophageal squamous cell carcinoma by regulating microRNA‑497‑5p and cell division cycle 25A

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