Interferon-Induced Cutaneous Necrosis

Sasseville, Denis; Ghamdi, Walid Al; Khenaizan, Sultan Al

doi:10.1177/120347549900300610

Cited by 15 publications

(7 citation statements)

References 19 publications

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“…On the contrary, a variety of reactions at injection sites of interferon alfa have been described including erythema, induration, 4 pyoderma gangrenosum, 5 interface dermatitis, 6 dermal hypersensitivity, 7 leukocytoclastic vasculitis, 8 necrotizing ulcerations 9,10 and suppurative and granulomatous dermatitis 11 . Other cutaneous reactions related to interferon beta‐1b include erythematous plaques, cutaneous ulcers or subtle uninflammed sclerotic dermal plaques at the injection sites 12 .…”

Section: Discussionmentioning

confidence: 99%

Lupus‐like reaction to interferon at the injection site: report of five cases

Arrue¹,

Sáiz²,

Ortiz‐Romero³

et al. 2007

J Cutan Pathol

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Multiple cutaneous lesions related to interferon at the injection site have been reported, but none of them with a histologic lupus-like presentation. In this study we describe five cases in which interferon therapy has induced a resolutive cutaneous lesion mimicking lupus erythematous. This peculiar microscopic pattern has been previously described once before, but interpreted as cutaneous mucinosis.

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Section: Discussionmentioning

confidence: 99%

Lupus‐like reaction to interferon at the injection site: report of five cases

Arrue¹,

Sáiz²,

Ortiz‐Romero³

et al. 2007

J Cutan Pathol

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“…1-3 Skin ulcerations seem to be an infrequent complication, usually not related to the dose or frequency of administration 4 : they have been reported to occur in less than 4% of patients treated with interferon beta, 5 and appear to occur even less frequently in association with interferon alfa. 6 In 1989 Rasokat et al 7 described the first two cases of aseptic necrosis of the skin after subcutaneous selfinjection of recombinant interferon alfa; the short delay (hours) after the injection and the clinical picture were consistent with inadvertent intraarterial embolization. Cutaneous necrosis caused by interferon alfa after several months of treatment was first reported by Cnudde et al 8 in 1991, and has been recently reviewed.…”

Section: Discussionmentioning

confidence: 96%

Cutaneous necrosis after injection of polyethylene glycol–modified interferon alfa

Dalmau

Pimentel

Puig

et al. 2005

Journal of the American Academy of Dermatology

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“…g) is a well-described adverse cutaneous drug reaction and can also exhibit signs of necrotizing vasculitis. [26][27][28][29][30] Thus, high local levels of IFN can in some instances cause massive localized tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Plasmacytoid (CD68+CD123+) Monocytes May Play a Crucial Role in the Pathogenesis of Hydroa Vacciniforme: A Case Report

Varughese

Petrella²,

Singer³

2009

The American Journal of Dermatopathology

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Hydroa vacciniforme (HV) is a rare, blistering, childhood photodermatosis that heals with smallpox-like scars, is associated with latent Epstein-Barr virus (EBV) infection, and spontaneously resolves by early adulthood. Cytotoxic T cells are suspected to mediate the histologic hallmark of HV-dense, perivascular, lymphocytic infiltrates and reticular degeneration and necrosis of the epidermis. We report a case of 13-year-old white girl with EBV-associated HV, whose lesional skin harbored a predominate CD68, CD123 infiltrate of plasmacytoid monocytes (PMs). Other significant pathologic attributes included abundant non-neutrophilic nuclear debris, necrosis of adnexal structures, lymphocytic vasculitis, and clusters of CD30 cells. PMs produce large amounts of type I interferon during viral infection, which induces apoptosis of some cell types and promotes the survival of others. This antiviral response can explain these aforementioned pathologic findings representing wide spread cell death and lymphoid proliferation, as well as eventual resolution of HV with time, via elimination of latent EBV-infected cells. The destruction of adnexal structures can account for the depressed circinate scars characteristic of HV. The validity of this proposed mechanism must be evaluated by first examining the prevalence and number of PMs in future case series of HV.

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Interferon-Induced Cutaneous Necrosis

Cited by 15 publications

References 19 publications

Lupus‐like reaction to interferon at the injection site: report of five cases

Lupus‐like reaction to interferon at the injection site: report of five cases

Cutaneous necrosis after injection of polyethylene glycol–modified interferon alfa

Plasmacytoid (CD68+CD123+) Monocytes May Play a Crucial Role in the Pathogenesis of Hydroa Vacciniforme: A Case Report

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