Interferon inactivator(s) in patients with AIDS and AIDS-unrelated Kaposi's sarcoma

Ikossi-O’Connor, M.G.; Chadha, Kailash C.; Lillie, Madeline A.; Bernstein, Zale P.; Zucker‐Franklin, Dorothea; Ambrus, Julian L.

doi:10.1016/0002-9343(86)90345-1

Cited by 20 publications

(1 citation statement)

References 11 publications

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“…However, if a deficient systemic response does exist in chronic hepatitis B, it seems likely that either the appropriate signal for such a response is lacking or HBV is capable of blocking the response, a situation which may be overcome by superinfection with another virus. Of interest, serum inhibitors or inactivators of IFN have been detected in AIDS but not in early HIV infection (22). This is relevant to the data of the present study, as only one of the 14 HIV-positive patients reported herein had AIDS by the Centers for Disease Control criteria.…”

Section: Discussionsupporting

confidence: 51%

Elevated HLA class i antigen expression on peripheral blood mononuclear cells of HBsAg carriers with coexistent human immunodeficiency virus infection

et al. 1987

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The density of HLA Class I antigen on peripheral blood mononuclear cells was evaluated by flow cytometry in the following groups of patients: 41 HBsAg carriers; 12 individuals with chronic non-A, non-B hepatitis, and 4 with acute hepatitis B. Fourteen of the carriers were positive for antibody to human immunodeficiency virus, and all were negative for antibody to delta agent. Elevated levels of Class I antigen were observed in only 19% of patients with chronic hepatitis B virus infection alone. In contrast, 86% of HBsAg carriers with coexistent human immunodeficiency virus infection demonstrated increased expression. These data suggest that HBsAg carriers are capable of sustaining a systemic interferon response to another chronic viral infection and further supports the hypothesis that a defective interferon response exists in chronic hepatitis B virus infection.

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Section: Discussionsupporting

confidence: 51%

Elevated HLA class i antigen expression on peripheral blood mononuclear cells of HBsAg carriers with coexistent human immunodeficiency virus infection

et al. 1987

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Interferon Inhibitory Activity in Patients With Multiple Sclerosis

et al. 2006

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The interferon system in carcinoma of the cervix. Effect of radiation and chemotherapy

Chadha¹,

Ambrus²,

Halpern³

et al. 1991

Cancer

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Thirteen patients with advanced carcinoma of the cervix were studied for parameters of the interferon system compared with 40 age-matched and sex-matched controls. All patients had measurable serum interferon levels; controls did not. All patients had non-antibody-type interferon-inhibitory activity, and controls had none. Interferon-synthesizing potential was higher in controls than in patients. After successful radiation and chemotherapy, these parameters normalized in the patients. No change was seen in one patient who did not respond to therapy.

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Interferon inactivator(s) in patients with AIDS and AIDS-unrelated Kaposi's sarcoma

Cited by 20 publications

References 11 publications

Elevated HLA class i antigen expression on peripheral blood mononuclear cells of HBsAg carriers with coexistent human immunodeficiency virus infection

Elevated HLA class i antigen expression on peripheral blood mononuclear cells of HBsAg carriers with coexistent human immunodeficiency virus infection

Interferon Inhibitory Activity in Patients With Multiple Sclerosis

The interferon system in carcinoma of the cervix. Effect of radiation and chemotherapy

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