Interferon in Acute Leukæmia in Children

Interferons and osteosarcoma

“…We observed a clinical effect in herpes zoster [10] and we gave IFN as a shield against infections in leukemic children with encouraging results [24].…”

Interferon-α in acute myeloid leukemia: an old drug revisited

“…Clinical activity of IFN-a in AML Clinical attempts to use IFN-a in the treatment of AML were already made in the mid-1960s and in the early 1970s (Falcoff et al 68 ; Ahstrom et al 69 ). While these pioneer studies did not allow to draw direct conclusions on its therapeutic value, the first evidence of in vivo antileukemic activity was provided by Hill et al in 1979.…”

“…Early studies of low-dose IFN-a failed to objectively demonstrate antileukemic responses, 69,74 the first clinical success was achieved after high-dose continuous intravenous administration of IFN-a 10 ( Table 2). Although some reports have suggested that low-dose IFN-a might be effective in AML, 75 the majority of the studies have indicated an association between IFN-a dosage and therapeutic efficacy.…”

Human Fibroblast Interferon for Clinical Trials: Pharmacokinetics and Tolerability in Experimental Animals and Humans

“…Our data as well as those reported in the literature (20,23) indicate that these effects were reduced or eliminated by alternative purification methods, suggesting that they were due to impurities. Febrile reactions have also been noted in patients with L-interferon (1,14,15,17,19,24). However, a recent preparation of purified L-interferon was not pyrogenic in a patient who showed a febrile response to F-interferon.…”