Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+ 874 A&gt;T polymorphism

Carneiro, Valdirene Leão; Bendicho, Maria Teresita; Santos, Rosalina Guedes Donato; Casela, Marilda; Netto, Eduardo Martins; Mota, Scarlet Torres Moraes; Pina, Iza Cristina Araújo; Nascimento, Roberto Meyer; Freire, Songelí Menezes; Barbosa, Theolis

doi:10.1016/j.bjid.2018.04.004

Cited by 2 publications

(1 citation statement)

References 34 publications

(37 reference statements)

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“…28 In another study, 11 out of 57 healthy controls (19%) with negative TST tested positive for QFT-IT. 29 Methodological differences seem to be the only plausible explanation to justify the lower prevalence of IGRA positivity in the healthy and DCTD controls of our study compared to that of other studies.…”

Section: Discussioncontrasting

confidence: 54%

High prevalence of latent tuberculosis using the QuantiFERON-TB Gold Plus test in Takayasu arteritis

et al. 2021

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Objectives: This study aims to investigate latent tuberculosis using the QuantiFERON-TB Gold Plus method in patients with Takayasu arteritis (TA). Patients and methods: This case-control study included 22 patients with TA (3 males, 19 females; median age: 36.5 years; IQR, 32 to 50 years), 22 healthy individuals (3 males, 19 females; median age: 38.5 years; IQR, 32.5 to 50 years), and 66 patients with diffuse connective tissue diseases (DCTDs) (4 males, 62 females; median age: 41 years; IQR, 29.8 to 54 years). Two control groups were formed: (i) age- and sex-matched healthy individuals and (ii) patients with other DCTDs. Epidemiological data were collected, and the QFT-Plus test was performed. The QFT-plus positivity was compared among the groups. Results: A higher prevalence of QFT-Plus positive cases was observed in the TA group (8/22) than in the healthy control group (1/22) (p=0.020) or in the group with other DCTDs (3/66) (p=0.001). There was a statistically significant difference in the past pulmonary tuberculosis prevalence between the TA and DCTD groups (p=0.013). Conclusion: The prevalence of latent tuberculosis in TA patients (36.4%) was higher than that in both control groups and higher than the prevalence of latent tuberculosis among the general Brazilian population. Although a positive association was found, it is not possible to establish a direct cause-effect relationship. Given the increasing use of anti-cytokine therapies in TA, it is necessary to thoroughly screen patients with TA before initiating immunosuppressive therapy to avoid tuberculosis reactivation.

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Section: Discussioncontrasting

confidence: 54%

High prevalence of latent tuberculosis using the QuantiFERON-TB Gold Plus test in Takayasu arteritis

et al. 2021

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Interferon-gamma +874A/T polymorphism in relation to susceptibility of periodontal disease: Systematic review

Maulani

Masulili

Auerkari

2019

AIP Conference Proceedings

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Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+ 874 A>T polymorphism

Abstract: The IFNG+874 polymorphism was not shown to influence QuantiFERON-TB Gold In-Tube test performance in an admixed population from northeastern Brazil.

Cited by 2 publications

References 34 publications

High prevalence of latent tuberculosis using the QuantiFERON-TB Gold Plus test in Takayasu arteritis

High prevalence of latent tuberculosis using the QuantiFERON-TB Gold Plus test in Takayasu arteritis

Interferon-gamma +874A/T polymorphism in relation to susceptibility of periodontal disease: Systematic review

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