Interferon gamma induction in human melanoma cell/allogeneic leukocyte co-cultures is enhanced by interleukin 18 but drug resistant melanoma cells are poorer inducers of IFN-γ

Enhanced Effects of Combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and Interleukin-18 on the Production of Tumour Necrosis Factor-α and Interferon-γ in Human Peripheral Blood Mononuclear Cells

“…1 -8 Our findings may provide valuable future direction for investigating the relationship between co-stimulatory molecule expression regulation in human monocytes and defence against bacterial pathogens. IL-18 is reported to be an anti-cancer agent, 37,38 so the additive effect of IL-18 and TJ-41 may be a useful anti-cancer treatment.…”