Interferon effects on interleukin-10 secretion Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients

Porrini, A.M.; Gambi, D.; Reder, Anthony T.

doi:10.1016/0165-5728(95)00070-i

Cited by 95 publications

(41 citation statements)

References 41 publications

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“…Some studies report the up-regulation of IL-10 production by substance P, 33 IFN-␣, 34 and IFN-␤. 35 It is of interest that the mouse IL-10 gene has shown regulatory motifs in the enhancer region similar to that in the IL-6 enhancer region because tacrolimus has been shown to enhance IL-6 production in human monocytes. IL-10 has been shown to suppress inflammatory cytokine production in humans.…”

Section: Discussionmentioning

confidence: 99%

Pretransplantation tumor necrosis factor-α production predicts acute rejection after liver transplantation

et al. 2000

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Immunosuppressive therapy has many adverse effects in both the short and longer term. Tailoring immunosuppression might be possible if pretransplantation parameters predicted rejection. We investigated production of the proinflammatory cytokine, tumor necrosis factor-␣ (TNF-␣), and the anti-inflammatory cytokine, interleukin-10 (IL-10), pretransplantation to determine whether there is a relation with acute rejection. Peripheral-blood mononuclear cells were obtained from patients with chronic liver disease on the waiting list for orthotopic liver transplantation and healthy controls. Cells (0.5 ؋ 10 6 ) were stimulated with 200 ng of lipopolysaccharide. Preincubation for 30 minutes with tacrolimus, cyclosporine, and dexamethasone at concentrations of 10 and 100 ng was also performed. TNF-␣ and IL-10 levels were measured by enzyme-linked immunosorbent assay. Acute rejection was defined on clinical and histological grounds. Pretransplantation in vitro production of TNF-␣ significantly (P < .05) increased in the group of patients with acute rejection (n ‫؍‬ 9) compared with those who did not develop rejection (n ‫؍‬ 12). Preincubation with dexamethasone significantly (P < .001) reduced TNF-␣ and IL-10 production in both patients and controls (n ‫؍‬ 8). IL-10 production pretransplantation was not different in those who developed acute rejection (n ‫؍‬ 9) compared with those who did not (n ‫؍‬ 9). Preincubation with tacrolimus augmented (P < .05) the production of IL-10 in patients (n ‫؍‬ 18), but not controls (n ‫؍‬ 6). Pretransplantation TNF-␣ production is increased in patients who go on to develop acute rejection posttransplantion. (Liver Transpl 2000;6:721-727.)

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Section: Discussionmentioning

confidence: 99%

Pretransplantation tumor necrosis factor-α production predicts acute rejection after liver transplantation

et al. 2000

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“…Monocytes from IFN-␤-treated MS patients can produce IL-10 (3,20). Interestingly, the level of IL-10 production in cultures containing total spleen cells from IFN--treated mice was similar to that observed when purified CD4 ϩ T cells from IFN--treated mice were restimulated with fresh APC (Fig.…”

Section: Resultsmentioning

confidence: 62%

Cutting Edge: Oral Type I IFN-τ Promotes a Th2 Bias and Enhances Suppression of Autoimmune Encephalomyelitis by Oral Glatiramer Acetate

Soos

Stüve

Youssef

et al. 2002

The Journal of Immunology

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IFN-τ, a novel type I IFN that possesses immunomodulatory properties, lacks toxicity normally associated with other type I IFNs. We examined the effects of oral IFN-τ alone and in combination with oral glatiramer acetate in experimental allergic encephalomyelitis (EAE). By comparison of oral administration of IFN-α, -β, and -τ to myelin basic protein-specific TCR-transgenic mice, we demonstrate these type I IFNs promote secretion of the Th2 cytokine IL-10 with similar efficiency. Whereas IFN-α and -β induced IFN-γ secretion, a Th1 cytokine, IFN-τ did not. Oral IFN-τ alone suppressed EAE. When suboptimal doses were administered orally in combination to wild-type mice, IFN-τ and glatiramer acetate had a synergistic beneficial effect in suppression of EAE. This combination was associated with TGF-β secretion and enhanced IL-10 production. Thus, IFN-τ is a potential candidate for use as a single agent or in combination therapy for multiple sclerosis.

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“…Suggested mechanisms of action of this cytokine are the inhibition of IFN-γ (43) and downregulation of MHC class II antigens on APC (44). Alternatively, the fact that IFN-ß inhibits the production of TNF in vitro and stimulates the production of IL-10 suggests that the latter might be an intermediate (45).…”

Section: Modulation Of the Th1-th2 Balance In Eaementioning

confidence: 99%

Role of Th1 and Th2 cells in autoimmune demyelinating disease

Nagelkerken¹

1998

Braz J Med Biol Res

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Evidence is accumulating that Th1 cells play an important role in the development of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), whereas Th2 cells contribute to recovery from disease. A major determinant in the development of Th1 and Th2 cells is the type of antigen-presenting cell (APC) involved and its functional characteristics, e.g., the production of interleukin-12. Therefore, modulation of APC might interfere with the development of Th1 type responses and as such be beneficial for MS and EAE. The potential of cytokines, in particular interleukin-10, and glucocorticoids to exert a selective effect on APC, and as a consequence to affect the Th1-Th2 balance in EAE, is discussed.

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Interferon effects on interleukin-10 secretion Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients

Cited by 95 publications

References 41 publications

Pretransplantation tumor necrosis factor-α production predicts acute rejection after liver transplantation

Pretransplantation tumor necrosis factor-α production predicts acute rejection after liver transplantation

Cutting Edge: Oral Type I IFN-τ Promotes a Th2 Bias and Enhances Suppression of Autoimmune Encephalomyelitis by Oral Glatiramer Acetate

Role of Th1 and Th2 cells in autoimmune demyelinating disease

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