Interferon associated retinopathy

Hayasaka, Seiji; Nagaki, Yasunori; Matsumoto, Masayuki; Sato, Shimio

doi:10.1136/bjo.82.3.323

Cited by 122 publications

(96 citation statements)

References 16 publications

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“…Hayasaka et al reviewed the subject in 1998 (28) and concluded that systemic hy per tension and diabetes mellitus were clear risk factors for eye disease during therapy with interferons. Chisholm et al (102) have reviewed the subject of asymptomatic ophthalmological disease in patients using interferon alpha.…”

Section: Discussionmentioning

confidence: 99%

Literature systematic review on the ophthalmological side effects of interferons

Fragoso¹,

Paggiaro²,

Mastromauro³

et al. 2011

Arq. Bras. Oftalmol.

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Interferons alpha and beta have been used worldwide for a few decades, altering the natural history of several severe diseases including hepatitis C, cancer and immu nemediated conditions such as multiple sclerosis. The adverse events profile of interferons is well established, but only isolated reports of ophthalmological compli ca tions of interferon therapy have been published. The objective of this study was to carry out a literature systematic review on the subject, bringing to light the need for ca reful ophthalmological monitoring of patients undergoing interferon treatment. Nearly 500 cases of ophthalmological complications related to interferon have been repor ted. The most frequent findings were soft exudates, hemorrhages and retina ischemia. Keywords BACKGROUNDInterferons are natural glycoproteins that have antiviral, antipro liferative and immune regulatory functions. There are several classes including interferon alpha, beta and gamma. Interferons alpha and beta are used worldwide in the treatment of several di seases including hepatitis C, cancer and immune-mediated condi tions such as multiple sclerosis. Due to the long-term use of interferons for most patients, the safety profile of these compounds is well known. Cutaneous(1) , hematological (2) , psychiatric (3,4) , endo crine (5) and hepatic (6) side effects of interferons have been reported. However, some side effects are specifically related to the eye, and a variety of ophthalmological diseases may arise from the use of inter ferons. Although recognised as relatively rare, ophthalmo lo gical complications due to interferons should be considered even if the patient is visually asymptomatic.The literature on the subject is restricted to case reports or a small series of cases. In order to better understand the most fre quent ophthalmological side effects of interferons and the outcome of these conditions, a literature systematic review was carried out.

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Section: Discussionmentioning

confidence: 99%

Literature systematic review on the ophthalmological side effects of interferons

Fragoso¹,

Paggiaro²,

Mastromauro³

et al. 2011

Arq. Bras. Oftalmol.

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“…Ophthalmological complications related to IFN administration were first described in 1990 by Ikebe et al in Japan and, since the introduction of IFN therapy for viral hepatitis, retinopathy has been identified as an important adverse effect of IFN therapy for this disease. 1 Incidence varies according to country and study design, with a high frequency of >50% reported in Japan, 1 suggesting that patients should be carefully monitored by ophthalmological assessment during treatment for viral hepatitis. Retinopathy reportedly develops between 2 weeks to 5 months after initiation of IFN therapy, and prevalence may depend on dosage of IFN received.…”

Section: Discussionmentioning

confidence: 99%

“…Many authors believe that diabetes mellitus is a strong risk factor, and arterial hypertension and old age are also suspected as possible risk factors. 1 Consensus is lacking regarding treatment for IFN retinopathy. As described in previous studies of viral hepatitis, most cases of IFN retinopathy are asymptomatic, and spontaneously improve over a period of several weeks, despite continued full-dose IFN treatment.…”

Section: Discussionmentioning

confidence: 99%

“…To date, a variety of adverse effects of IFN use have been described, and flu-like symptoms, inflamed injection sites, and depression are widelyknown as frequent adverse effects in MS. 1 Herein we report a case of IFN-associated retinopathy in a patient with MS receiving subcutaneous IFNβ-1b treatment and reviewed the clinical properties of this adverse effect in MS.…”

Section: Introductionmentioning

confidence: 99%

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Retinopathy: An Overlooked Adverse Effect of Interferon-beta Treatment of Multiple Sclerosis

Ohira¹,

Ito²,

Shimizu³

et al. 2009

Keio J. Med.

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“…Somente 15 a 20% destes pacientes apresentam resposta sustentada à terapia com interferon alfa -INFα (3)(4) , mas a combinação da terapia com ribavirina aumenta significativamente esse índice (5)(6) . O INFα, um agrupamento complexo de proteínas, com atividades antivirais, antiproliferativas e imunorregulatórias, é uma droga atualmente utilizada não só no tratamento da hepatite C crônica, mas também de condições sistêmicas, como o sarcoma de Kaposi, os hemangiomas, os melanomas cutâneos e o carcinoma renal metastático (7) .…”

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Trombose de veia central da retina em paciente usuária de interferon e ribavirina: relato de caso

Helal¹,

Zacharias²,

Alencar³

2006

Arq. Bras. Oftalmol.

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Descritores: Hepatite C; Ribavirina/efeitos adversos; Interferon/efeitos adversos; Retinopatia; Oclusão da veia retiniana; Relato de casos [tipo de publicação] INTRODUÇÃOA infecção crônica pelo vírus da hepatite C afeta cerca de 4 milhões de pessoas nos Estados Unidos e aproximadamente 170 milhões em todo o mundo (1)(2) . Somente 15 a 20% destes pacientes apresentam resposta sustentada à terapia com interferon alfa -INFα (3)(4) , mas a combinação da terapia com ribavirina aumenta significativamente esse índice (5)(6) . O INFα, um agrupamento complexo de proteínas, com atividades antivirais, antiproliferativas e imunorregulatórias, é uma droga atualmente utilizada não só no tratamento da hepatite C crônica, mas também de condições sistêmicas, como o sarcoma de Kaposi, os hemangiomas, os melanomas cutâneos e o carcinoma renal metastático (7) . A ribavirina, por sua vez, é um nucleosídio sintético, análogo à guanidina, com propriedades anti-retrovirais contra uma série de DNA e RNA vírus (8) , e também com atividade imunorregulatória (9) . A terapia com INFα é associada a vários efeitos colaterais sistêmicos, como fadiga, mal-estar, perda de peso, depressão, náusea, anorexia, diarréia, neutropenia e trombocitopenia (10)(11)(12) . Em 1993, Guyer e colaboradores descreveram uma forma de retinopatia associada à terapia com interferon, marcada pela presença de exsudatos algodonosos e hemorragias intraretinianas (13) . Desde então, vários relatos demonstraram alterações oculares associadas ao uso desta droga.A retinopatia típica inclui exsudatos algodonosos e hemorragias retiniaTrombose de veia central da retina em paciente usuária de interferon e ribavirina: relato de caso O interferon alfa (INF α) é droga atualmente utilizada no tratamento de várias doenças sistêmicas, como a hepatite C crônica. A ribavirina quando associada ao interferon alfa aumenta muito a resposta ao tratamento. Estima-se que a infecção crônica pelo vírus da hepatite C afete 170 milhões de pessoas no mundo, muitas delas em uso dessas medicações. A forma típica da retinopatia associada ao interferon alfa apresenta exsudatos algodonosos e hemorragias intra-retinianas. Há vários relatos de alterações oculares associadas ao uso do interferon alfa. Este trabalho descreve um caso de oclusão de veia central da retina em olho direito, com hemorragias no olho contralateral, em paciente usuária dessas medicações por dois anos. O caso descrito expõe em um dos olhos o quadro mais freqüente da retinopatia associada ao uso de interferon alfa (hemorragias de fundo) e no olho contralateral, uma apresentação muito mais atípica (trombose de veia central da retina). O quadro fundoscópico apresentou melhora com a interrupção da medicação. RESUMO RELATOS DE CASOS

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Interferon associated retinopathy

Cited by 122 publications

References 16 publications

Literature systematic review on the ophthalmological side effects of interferons

Literature systematic review on the ophthalmological side effects of interferons

Retinopathy: An Overlooked Adverse Effect of Interferon-beta Treatment of Multiple Sclerosis

Trombose de veia central da retina em paciente usuária de interferon e ribavirina: relato de caso

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