Interferon and natural killer cell activity in patients with exanthem subitum

Takahashi, Kimio; Segal, Ella Shtifman; Kondo, Toshio; Mukai, T.; Moriyama, Masaya; Takahashi, M; Yamanishi, Koichi

doi:10.1097/00006454-199205000-00006

Cited by 34 publications

(24 citation statements)

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“…Our results may also explain the in vivo observations of Takahashi et al (20) who have reported higher NK activity in patients with acute HHV-6 infection. Our data also suggest that, although HHV-6 can interact with NK cells, these cells are still functional during the first days post-infection and, moreover, they are highly cytolytic as a consequence of IL-15 release by PBMC in response to HHV-6 infection.…”

Section: Discussionsupporting

confidence: 88%

“…The present results show for the first time that the early events of immune cell activation such as NK cell cytotoxicity observed following infection by HHV-6, a human lymphotropic herpesvirus, are mediated via IL-15 induction, and also confirm that this cytokine is indeed a potent stimulator of NK activity. Our data may also explain the increase in NK activity during the acute febrile phase of HHV-6 infection (exanthem subitum) reported by other investigators (20).…”

Section: Introductionsupporting

confidence: 81%

“…NK cell activity was determined by standard 51 Cr-release assay (20). Briefly, K562 target cells (10 6 ) were labeled with 100 Ci of sodium chromate (DuPont, Canada) for 60 min at 37 Њ C. After four washes, the target cells (10 4 ) were mixed with effector PBMC at a 1:20 ratio in V-bottomed wells and incubated for 16 h at 37 Њ C in a CO 2 incubator.…”

Section: Methodsmentioning

confidence: 99%

“…Patients' NK activity during the acute febrile phase of HHV-6 infection has been shown to be increased when compared to that of NK activity of patients in convalescence (20). In an effort to better understand this phenomenon, we studied NK activity of PBMC from healthy individuals after in vitro infection by HHV-6.…”

Section: Hhv-6 Increases Cytotoxic Activity Of Cd16 ϩ Cellsmentioning

confidence: 99%

“…However, there are no studies on the consequences of HHV-6 infection on NK cell activity per se. One group has reported that during the acute febrile phase of HHV-6 infection there was a significant increase in NK cytotoxicity when compared to the NK activity observed during convalescence (20). Our objective was to learn more about, and evaluate the potential effect of, HHV-6 infection on NK cell activity.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15.

Flamand¹,

Stefănescu²,

Menezes³

1996

J. Clin. Invest.

133

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show abstract

Section: Discussionsupporting

confidence: 88%

Section: Introductionsupporting

confidence: 81%

Section: Methodsmentioning

confidence: 99%

Section: Hhv-6 Increases Cytotoxic Activity Of Cd16 ϩ Cellsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15.

Flamand¹,

Stefănescu²,

Menezes³

1996

J. Clin. Invest.

133

View full text Add to dashboard Cite

show abstract

Betaherpesviruses: Cytomegalovirus, Human Herpesviruses 6 and 7

Britt

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

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Time course characteristics of human herpesvirus 6 specific cellular immune response and natural killer cell activity in patients with exanthema subitum

Kumagai¹,

Yoshikawa

Yoshida

et al. 2006

Journal of Medical Virology

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The time-course of cell-mediated immunity in exanthema subitum is not well documented. The lymphoproliferative response to purified human herpesvirus 6 (HHV-6) antigen and to phytohemagglutinin was measured and natural killer (NK) cell activities determined in three consecutive specimens obtained biweekly from 18 young children and infants with exanthema subitum. Virus isolation and PCR detection of virus DNA and determination of neutralization antibody to HHV-6 and -7 were also carried out. The magnitude of the HHV-6 specific lymphoproliferative response varied; however, in most cases the time course kinetics revealed a low response in the acute phase with a subsequent gradual increase. In contrast, NK cell activities were high in the acute phase and declined gradually during convalescence. The lymphoproliferative response to phytohemagglutinin did not show a consistent trend in kinetics of time; however, dynamic changes in activity were observed in patients during the acute and convalescent periods. The results suggest that NK cells play a major role in resolving acute phase infection while specific lymphocyte activity develops later. The cause of the delayed development of HHV-6 specific lymphoproliferative response is unknown. The lymphoproliferative response to phytohemagglutinin ratios implied that HHV-6 infection has some impact on host T-cell immunity during the course of exanthema subitum.

show abstract

Interferon and natural killer cell activity in patients with exanthem subitum

Cited by 34 publications

References 0 publications

Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15.

Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15.

Betaherpesviruses: Cytomegalovirus, Human Herpesviruses 6 and 7

Time course characteristics of human herpesvirus 6 specific cellular immune response and natural killer cell activity in patients with exanthema subitum

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