Interferon and Genital Warts: Much Potential, Modest Progress

Kirby, Phil

doi:10.1001/jama.1988.03720040062030

Cited by 20 publications

(5 citation statements)

References 16 publications

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“…Trauma may play a role in the development of the lesions. Human papillomavirus infection is characterized by a long latent period, 2–3 months, 2 and subclinical or preclinical infection in up to 11% of individuals, 5 making it difficult in some instances to identify the source of the infection.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with anogenital condyloma acuminatum are at risk for other sexually transmitted diseases, most often chlamydia, syphilis, and gonorrhea 5 . Patients with oral condyloma should be evaluated with this in mind.…”

Section: Treatmentmentioning

confidence: 99%

“…Condylomas, or venereal warts, are more common on anogenital skin and mucosa. The number of physician visits for genital warts increased almost 600% between 1966 and 1983 in the United States 5 . Human papilloma virus (HPV) infection, including condylomas, gonorrhea, and chlamydia, are the most commonly diagnosed sexually transmitted diseases in the United States today 5 .…”

Section: Introductionmentioning

confidence: 99%

“…The number of physician visits for genital warts increased almost 600% between 1966 and 1983 in the United States 5 . Human papilloma virus (HPV) infection, including condylomas, gonorrhea, and chlamydia, are the most commonly diagnosed sexually transmitted diseases in the United States today 5 . The first reported case of an oral condyloma was in 1967 by Knapp and Uohara 6 .…”

Section: Introductionmentioning

confidence: 99%

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Oral Condyloma Acuminatum

Zunt

Tomich

1989

The Journal of Dermatologic Surgery and Oncology

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Abstract. Fifty‐one cases of oral condyloma acuminatum are reported, bringing the total number in the English medical/dental literature to approximately 156 cases. Ninety‐five percent of the 59 new cases were in males. Eighty‐one percent occurred in the age range of 21–40 years. The most common locations were upper lip, lingual frenum, dorsum of the tongue, and lower lip. Thirty‐four percent presented with multiple lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oral Condyloma Acuminatum

Zunt

Tomich

1989

The Journal of Dermatologic Surgery and Oncology

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“…Inter ferons down-regulate [21] and leukoregulin up-regulates [22] tumor cell sensitivity to NK lymphocyte cytotoxicity. Interferons recently have been introduced in the treatment of HPV-associated lesions and cervical intraepithelial neo plasia because the response rate to conventional chemo therapeutic treatment is highly variable and in most cases is less than 50% [23,24], Interferons are well known for their antiviral activity and for their immunomodulatory functions. Most interferon therapy of HPV-associated lesions and cervical intraepithelial neoplasia has been performed with a-interferon or p-interferon [25], More recently, clinical trials have begun with y-interferon [26.…”

Section: Lymphocytes and Cytokines In Cervical Cancermentioning

confidence: 99%

Cytokine Modulation of Immune Defenses in Cervical Cancer

Evans¹,

Flugelman²,

DiPaolo³

1993

Oncology

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Human papilloma viruses (HPV) are major factors in the etiology of cervical cancer. Natural killer (NK) lymphocytes, an important defense against viral diseases, are present in most HPV-associated lesions and cervical intraepithelial neoplasia. HPV positive cervical cancer cells and HPV-immortalized human cervical epithelial cells which possess properties similar to cervical dysplasia, however, are resistant to NK but are sensitive to lymphokine-activated killer (LAK) lymphocyte lysis. Sensitivity can be enhanced by treatment of cervical cells with leukoregulin, a cytokine secreted by lymphocytes. Combination treatment with leukoregulin and a chemotherapeutic drug, e.g. cisplatin, further enhances sensitivity of HPV-infected cells to LAK lymphocyte lysis. In contrast, gamma-interferon treatment of cervical cells can result in decreased sensitivity to LAK lysis illustrating the potential balance cytokines can exert in the immunologic control of cervical cancer.

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