INTERFERON AND CELL DIVISION, I. INHIBITION OF THE MULTIPLICATION OF MOUSE LEUKEMIA L 1210 CELLS In Vitro BY INTERFERON PREPARATIONS

Abstract

Abstract. Mouse interferon preparations inhibited the multiplication of mouse leukemia L 1210 cells in stationary suspension cultures. The degree of inhibition was found to correlate with the antiviral titer of the interferon preparations. The factor(s) responsible for inhibition of L 1210 cell multiplication could not be dissociated from interferon by standard physicochemical means.

Interferon: Effect on the Saturation Density to Which Mouse Cells Will Grow in Vitro

“…These results confirm the earlier work of Paucker Cantell, and Henle (3) and extend that of Gresser and co-workers (4,5,9). Furthermore, recent reports have shown that mouse interferon reduces the final cell density as well as the growth rate of L1210 cells (9) and mouse embryo and mouse kidney primary cells (5).…”

“…Moreover, preparations of mouse interferon, both crude and partially purified, have been shown to inhibit the growth of mouse L cells (3) and mouse lymphoid leukemia cells (4) in suspension culture. Recently, crude preparations of mouse interferon have been reported to inhibit the growth in monolayer culture of L, mouse embryo, and mouse kidney cells (5).…”

Growth inhibitory effects of interferon on blast cells from patients with acute myelogenous leukaemia

“…The growth inhibitory effect of Interferon was shown to be dose dependent by Gresser, studying mouse Interferon and L1210 leukaemia (Gresser et al, 1970). Similar findings have subsequently been reported for the antiproliferative activity of human lymphoblastoid, leukocyte and fibroblast Interferons on human leukaemic myeloblasts in short-term liquid culture (Balkwill & Oliver, 1977;Lundgren et al, 1980).…”

Resistance to Interferon of a Human Adenocarcinoma Cell Line, HEC-1, and its Sensitivity to Natural Killer Cell Action

“…On the other hand, the sensitivities of cells to interferons vary (Adams et al, 1975;Hilfenhaus et al, 1977). The antiviral action of interferon and the cell growth-inhibiting action of interferons are expressed in parallel in various cells (Gresser et al, 1970;Gresser et aL, 1974). However, in certain cases, cells are sensitive to the antiviral action, but resistant to the cell growth-inhibiting action of interferon (Kuwata et al, 1976;Kuwata et al, 1979;Fuchsberger et aL, 1974).…”