Interferon-&amp;gamma; in Schizophrenia

Arolt, Volker; Weitzsch, Christine; Rothermundt, Matthias; Eckhoff, Dörte; Kirchner, H.

doi:10.1159/000058636

Cited by 2 publications

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“…30 However, as in the majority of studies in this area, only a cross-sectional approach was employed, which did not yield any information about changes in cytokine production while patients were undergoing remission. 31 Encouraged by our preliminary findings, patients undergoing treatment due to worsening of schizoMolecular Psychiatry phrenic symptoms were investigated in this study and the production of IFN-␥ and IL-2 by lymphocytes of patients and healthy age-and gender-matched controls were examined. It was our intention to investigate in a larger patient sample whether IFN-␥ as well as IL-2 is reduced in acute schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment

et al. 2000

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A pattern of aberrations in the T-cell cytokine system that is typical for autoimmune disorders has also been reported in patients with schizophrenia, namely a decreased interleukin-2 (IL-2) production and increased levels of the soluble IL-2 receptor (sIL-2R). It has also been reported that the production of interferon-␥ (IFN-␥) may be lowered. In a longitudinal design, we studied the production of both IFN-␥ and IL-2 and their correlation in patients with schizophrenia during treatment and investigated whether associations exist between cytokine production and clinical variables. The production of IFN-␥ and IL-2 was measured in equal numbers (n = 29) of patients with schizophrenia (DSM-IV) and controls who were matched for age and gender. Patients were measured 1 day after admission (T1), after 14 (T2) and 28 (T2) days of treatment. Psychopathology was assessed after these times. The production of both IFN-␥ and IL-2 was significantly lower in patients than in controls throughout the whole investigation period (T1-T3). The productions of both cytokines were significantly correlated in controls (r = 0.60, P Յ 0.001) as well as in patients with schizophrenia (mean production T1-T3: r = 0.71, P Յ 0.001). No associations between cytokine measurements and psychopathology or age-at-onset could be found. Our findings of lowered and correlated IFN-␥ and IL-2 production indicate that alterations in the cytokine system of patients with schizophrenia might resemble those in autoimmune disorders. It is suggested that these immunological abnormalities are associated with acute exacerbation, rather than with a clinical subtype of schizophrenia. Molecular Psychiatry (2000) 5, 150-158.

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Section: Introductionmentioning

confidence: 99%

Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment

et al. 2000

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“…IFNG controls IL6 gene regulation 57 which can be increased in myeloid cells if ADORA2B is activated 58 . This subnetwork plays a crucial role in neuro-immune interaction which has been proposed as a potential mechanism in many neurodevelopmental and psychiatric disorders [58][59][60] (Supplementary Table 9).…”

Section: Notes Ii)mentioning

confidence: 99%

A statistical method for image-mediated association studies discovers genes and pathways associated with four brain disorders

Antonyan

Zhu

et al. 2023

Preprint

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Brain imaging and genomics are critical tools enabling characterization of the genetic basis of brain disorders. However, imaging large cohorts is expensive, and may be unavailable for legacy datasets used for genome-wide association studies (GWAS). Using an integrated feature selection/aggregation model, we developed Image-Mediated Association Study (IMAS), which utilizes borrowed imaging/genomics data to conduct association mapping in legacy GWAS cohorts. By leveraging the UK Biobank image-derived phenotypes (IDPs), IMAS discovered genetic bases underlying four neuropsychiatric disorders and verified them by analyzing annotations, pathways, and expression Quantitative Trait Loci (eQTLs). A cerebellar-mediated mechanism was identified to be common to the four disorders. Simulations show that, if the goal is identifying genetic risk, IMAS is more powerful than a hypothetical protocol in which the imaging results were available in the GWAS dataset. This implies the feasibility of reanalyzing legacy GWAS datasets without conducting additional imaging, yielding cost-savings for integrated analysis of genetics and imaging.

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Interferon-γ in Schizophrenia

Cited by 2 publications

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Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment

Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment

A statistical method for image-mediated association studies discovers genes and pathways associated with four brain disorders

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