Interferences in solid-phase extraction using C-18 bonded porous silica cartridges

Junk, Gregor A.; Avery, Michael J.; Richard, John J.

doi:10.1021/ac00164a021

Cited by 101 publications

(31 citation statements)

References 38 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pre-washing the cartridges could prevent the occurence of the interfering peaks. Junk et al [52] investigated the possibly interfering compounds extracted from the polypropylene housing, the polyethylene frits and the Clg-bonded silica phase. The main compounds identified in extracts of the cartridges were remnants of the polymerisation process (alkanes and alkenes), plasticizers and antioxidants.…”

Section: Contamination From the Cartridgementioning

confidence: 99%

Analyte isolation by solid phase extraction (SPE) on silica-bonded phases: Classification and recommended practices (Technical Report)

Moors¹,

Massart²,

McDowall³

1994

Pure and Applied Chemistry

View full text Add to dashboard Cite

show abstract

Section: Contamination From the Cartridgementioning

confidence: 99%

Analyte isolation by solid phase extraction (SPE) on silica-bonded phases: Classification and recommended practices (Technical Report)

Moors¹,

Massart²,

McDowall³

1994

Pure and Applied Chemistry

View full text Add to dashboard Cite

show abstract

“…Improperly cleaned glassware is often associated with anomalous results in LC separations; soap residues have also been associated with ghost peaks in a chromatogram [4]. Plastics are also a common source of contamination, and interferences resulting from various extractables and plasticizers have been the subject of various reports [5][6][7].…”

mentioning

confidence: 99%

Cyclic polyamide oligomers extracted from nylon 66 membrane filter disks as a source of contamination in liquid chromatography/mass spectrometry

Tran

Doucette

2006

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

Background interferences are perhaps an unavoidable part of analytical detection schemes, particularly when analyzing trace level samples or when using detectors with high levels of sensitivity. In liquid chromatography, mobile phase solvents are routinely filtered using membrane filter disks to trap particulates in hopes of minimizing contamination, providing improvements in data output and instrumental operation. In this study, we report that one such filter disk leads to a significant level of contamination in LC and LC/MS experiments. Extractable compounds from nylon membrane filters generate significant background signals in UV absorption chromatograms at 214 nm, and are also detected by electrospray ionization mass spectrometry, with nominal m/z values of 453 and 679. It is shown that rinsing the nylon membranes before their use can reduce, but will not eliminate, the extractable contaminants from the mobile phase. Through MS and tandem MS analysis, we have identified these contaminants as cyclic oligomers of polyamide 66. Based on these results, it is recommended that nylon membrane filters be avoided when conducting trace level analysis, particularly when conducting LC/MS experiments. (J Am Soc Mass Spectrom 2006, 17, 652-656)

show abstract

“…The functional groups of the particleloaded membranes must be solvated and thus activated. Also in this step, the unwanted matrix impurities of the sorbent, cartridges and disks arising from their manufacture must be eliminated in order to minimize contaminations [66]. Next, the conditioning solvent is rinsed from the sorbent with the same solvent as the sample solvent (or a similar solvent with respect to polarity, pH and ion activity).…”

Section: Methodsmentioning

confidence: 99%

Determination of higher carboxylic acids in snow samples using solid-phase extraction and LC/MS-TOF

2008

View full text Add to dashboard Cite

The objective of this work was to develop a method to determine the concentrations of higher organic acids in snow samples. The target species are the homologous aliphatic α,ω-dicarboxylic acids from C 5 to C 13 , pinonic acid, pinic acid and phthalic acid. A preconcentration procedure utilizing solid phase extraction was developed and optimized using solutions of authentic standards. The influences of different parameters such as flow rate during extraction and the concentration of the eluent on the efficiency of the extraction procedure were investigated. The compounds of interest were separated by HPLC and detected by a quadrupole time-of-flight mass spectrometer (qTOF-MS). The recovery rate (extraction efficiency) of the extraction procedure was found to vary between 41% for tridecanedioic acid and 102% for adipic acid. The limits of detection were determined for all compounds and were between 0.9 nmol/L (dodecanedioic acid) and 29.5 nmol/L (pinonic acid). An exception is pinic acid, for which a considerably higher detection limit of 103.9 nmol/L was calculated. Snow samples were collected in December 2006 and January 2007 at the Fee glacier (Switzerland) from locations at heights from 3056 to 3580 m asl and from different depths within the snow layer. In total, the analysis of 61 single snow samples was performed, and the following compounds could be quantified: homologous aliphatic α,ω-dicarboxylic acids with 5-12 carbon atoms and phthalic acid. Tridecanedioic acid, pinonic and pinic acid were identified in the samples but were not quantified due to their low concentrations. The three most abundant acids found in the molten snow samples were glutaric acid (C 5 -di; 3.90 nmol/L), adipic acid (C 6 -di; 3.35 nmol/L) and phthalic acid (Ph; 3.04 nmol/L).

show abstract

Interferences in solid-phase extraction using C-18 bonded porous silica cartridges

Cited by 101 publications

References 38 publications

Analyte isolation by solid phase extraction (SPE) on silica-bonded phases: Classification and recommended practices (Technical Report)

Analyte isolation by solid phase extraction (SPE) on silica-bonded phases: Classification and recommended practices (Technical Report)

Cyclic polyamide oligomers extracted from nylon 66 membrane filter disks as a source of contamination in liquid chromatography/mass spectrometry

Determination of higher carboxylic acids in snow samples using solid-phase extraction and LC/MS-TOF

Contact Info

Product

Resources

About