Interference Requirements of Type III CRISPR-Cas Systems fromThermus thermophilus
Karyna Karneyeva,
Matvey Kolesnik,
Alexei Livenskyi
et al.
Abstract:Among the diverse prokaryotic adaptive immunity mechanisms, the Type III CRISPR-Cas systems are the most complex. The multisubunit Type III effectors recognize RNA targets complementary to CRISPR RNAs (crRNAs). Target recognition causes synthesis of cyclic oligoadenylates that activate downstream auxiliary effectors, which affect cell physiology in complex and poorly understood ways. Here, we studied the ability of III-A and III-B CRISPR-Cas subtypes fromThermus thermophilusto interfere with plasmid transforma… Show more
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