Interference of propylene glycol with the hole-board test

Al, da Silva; Elisabetsky, Elaine

doi:10.1590/s0100-879x2001000400016

Cited by 20 publications

(1 citation statement)

References 10 publications

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“…La prueba de la plataforma agujereada fue introducida en 1962 por Boisser y Simón [38]. El uso de esta prueba para evaluar sustancias ansiolíticas se basa en la hipótesis de Montgomery (1955) [39] de que la exposición a un nuevo ambiente le crea al ratón un conflicto entre el temor generado por la novedad de la situación y su tendencia natural a explorar [40]. Hay una variedad de diseños [41,42]; entre ellos, frecuentemente se utiliza una plataforma gris de 40 x 40 cm y 2,2 cm de espesor, con 16 orificios de 3 cm de diámetro distribuidos equidistantemente en la superficie, y puesta sobre un soporte a una altura de 15 cm [43][44][45].…”

Section: Pruebas No Condicionadasunclassified

Pruebas no condicionadas en ratones para evaluar la actividad ansiolítica de sustancias extraídas de plantas

2010

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En el último año, el Laboratorio Experimental de Farmacobiología de la Facultad de Medicina de la Universidad Autónoma de Chiapas (UNACH), ha venido sistematizando pruebas no condicionadas para el estudio de la ansiedad en modelos animales. En este trabajo se efectúa una revisión bibliográfica que actualiza el conocimiento sobre las pruebas útiles en la evaluación de la ansiedad. Estas pruebas las utilizamos en los trabajos de investigación de extractos vegetales con base en hallazgos etnobotánicos de la medicina tradicional chiapaneca, los cuales se han desarrollado con modestos recursos financieros de la Facultad de Medicina de la Universidad y autofinanciamiento por parte de los investigadores, considerando la generación de conocimiento y la posibilidad de ampliar las expectativas terapéuticas con recursos naturales, como el insumo de mayor valor.Además, es de interés para el equipo investigador vincular en este proceso a investigadores de otras universidades e instituciones de salud que estén estudiando compuestos extraídos de plantas y que sirvan como base en la obtención de fármacos no sintéticos para tratamiento de la ansiedad en el hombre.

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Section: Pruebas No Condicionadasunclassified

Pruebas no condicionadas en ratones para evaluar la actividad ansiolítica de sustancias extraídas de plantas

2010

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The long-term effects of repeated heroin vapor inhalation during adolescence on measures of nociception and anxiety-like behavior in adult Wistar rats

et al. 2022

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Rationale Adolescents represent a vulnerable group due to increased experimentation with illicit substances that is often associated with the adolescent period, and because adolescent drug use can result in long-term effects that differ from those caused by drug use initiated during adulthood. Objectives The purpose of the present study was to determine the effects of repeated heroin vapor inhalation during adolescence on measures of nociception, and anxiety-like behavior during adulthood in female and male Wistar rats. Methods Rats were exposed twice daily to 30 min of heroin vapor from post-natal day (PND) 36 to PND 45. At 12 weeks of age, baseline thermal nociception was assessed across a range of temperatures with a warm-water tail-withdrawal assay. Anxiety-like behavior was assessed in an elevated plus-maze (EPM) and activity was measured in an open-field arena. Starting at 23 weeks of age, baseline thermal nociception was re-assessed, nociception was determined after acute heroin or naloxone injection, and anxiety-like behavior was redetermined in the EPM. Results Adolescent heroin inhalation altered baseline thermal nociception in female rats at 12 weeks of age and in both female and male rats at ~ 23 weeks. Heroin-treated animals exhibited anxiety-like behavior when tested in the elevated plus-maze, showed blunted heroin-induced analgesia, but exhibited no effect on naloxone-induced hyperalgesia. Conclusions The present study demonstrates that heroin vapor inhalation during adolescence produces behavioral and physiological consequences in rats that persist well into adulthood.

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Developmental toxicity and neurotoxicity assessment of R-, S-, and RS-propylene glycol enantiomers in zebrafish (Danio rerio) larvae

Shen

Zhao

et al. 2022

Environ Sci Pollut Res

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Propylene glycol (PG) is widely used in the foods, pharmaceuticals, oil industry, animal feed, cosmetics and other industries. Because of the existence of a chiral carbon center, PG forms R (Rectus)-and S (Sinister)-enantiomers. Currently, the toxicity study of its R-, S-enantiomers is still very scarce. In this study, we have assessed the developmental toxicity and neurotoxicity of the R-, S-, and RS-PG enantiomers in zebra sh larvae. We found that exposure to R-, S-, and RS-PG enantiomers did not signi cantly affect the basic developmental endpoints of embryos or larvae (i.e., embryonic movement, hatching, mortality, malformation, heartbeat, body length), indicating that R-, S-, and RS-PG exposures did not exhibit the basic developmental toxicity in zebra sh larvae. The toxicity of the three enantiomers was lower than that of ethanol, and there was no signi cant difference between them. However, R-, S-, and RS-PG exposures with high doses could signi cantly change the eye diameter and the locomotor activity of larval zebra sh, indicating that R-, S-, and RS-PG enantiomers of high doses can potentially exhibit the neurotoxicity and ocular developmental toxicity in zebra sh larvae. Therefore, the potential neurotoxicity and ocular developmental toxicity of R-, S-, and RS-PG enantiomers for infants and toddlers should be considered.

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Interference of propylene glycol with the hole-board test

Cited by 20 publications

References 10 publications

Pruebas no condicionadas en ratones para evaluar la actividad ansiolítica de sustancias extraídas de plantas

Pruebas no condicionadas en ratones para evaluar la actividad ansiolítica de sustancias extraídas de plantas

The long-term effects of repeated heroin vapor inhalation during adolescence on measures of nociception and anxiety-like behavior in adult Wistar rats

Developmental toxicity and neurotoxicity assessment of R-, S-, and RS-propylene glycol enantiomers in zebrafish (Danio rerio) larvae

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