Interference of dietary polyphenols with potentially toxic amino acid metabolites derived from the colonic microbiota

Gasaly, Naschla; Gotteland, Martín

doi:10.1007/s00726-021-03034-3

Cited by 13 publications

(8 citation statements)

References 107 publications

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“…Similarly to indoles, phenol and p -cresol are derived from proteolytic fermentation of undigested or partially digested proteins and have been shown to damage the gut mucosa disrupting the epithelial barrier function and being genotoxic (Al Hinai et al 2019 ; Wang et al 2020 ). Also in farm animals, the excessive production of these metabolites can affect the quality of meat and milk and is a source of contaminating emissions from animal manure (Gasaly and Gotteland 2022 ). In our work, phenol and p -cresol should be derived from fermentation of tyrosine due to proteolysis of milk.…”

Section: Discussionmentioning

confidence: 99%

Maternal amoxicillin affects piglets colon microbiota: microbial ecology and metabolomics in a gut model

Nissen

Aniballi

Casciano

et al. 2022

Appl Microbiol Biotechnol

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The first weeks of life represent a crucial stage for microbial colonization of the piglets’ gastrointestinal tract. Newborns’ microbiota is unstable and easily subject to changes under stimuli or insults. Nonetheless, the administration of antibiotics to the sow is still considered as common practice in intensive farming for pathological conditions in the postpartum. Therefore, transfer of antibiotic residues through milk may occurs, affecting the piglets’ colon microbiota. In this study, we aimed to extend the knowledge on antibiotic transfer through milk, employing an in vitro dedicated piglet colon model (MICODE—Multi Unit In vitro Colon Model). The authors’ focus was set on the shifts of the piglets’ microbiota composition microbiomics (16S r-DNA MiSeq and qPCR—quantitative polymerase chain reaction) and on the production of microbial metabolites (SPME GC/MS—solid phase micro-extraction gas chromatography/mass spectrometry) in response to milk with different concentrations of amoxicillin. The results showed an effective influence of amoxicillin in piglets’ microbiota and metabolites production; however, without altering the overall biodiversity. The scenario is that of a limitation of pathogens and opportunistic taxa, e.g., Staphylococcaceae and Enterobacteriaceae, but also a limitation of commensal dominant Lactobacillaceae, a reduction in commensal Ruminococcaceae and a depletion in beneficial Bifidobactericeae. Lastly, an incremental growth of resistant species, such as Enterococcaceae or Clostridiaceae, was observed. To the authors’ knowledge, this study is the first evaluating the impact of antibiotic residues towards the piglets’ colon microbiota in an in vitro model, opening the way to include such approach in a pipeline of experiments where a reduced number of animals for testing is employed. Key points • Piglet colon model to study antibiotic transfer through milk. • MICODE resulted a robust and versatile in vitro gut model. • Towards the “3Rs” Principles to replace, reduce and refine the use of animals used for scientific purposes (Directive 2010/63/UE). Graphical abstract

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Section: Discussionmentioning

confidence: 99%

Maternal amoxicillin affects piglets colon microbiota: microbial ecology and metabolomics in a gut model

Nissen

Aniballi

Casciano

et al. 2022

Appl Microbiol Biotechnol

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“…122 On the other hand, a recently published review study connects dietary polyphenols' ability to the reduced formation of H 2 S from the gut microbiota. 123…”

Section: H 2 S Metabolism and Signaling Pathwaysmentioning

confidence: 99%

Impact of the Gastrointestinal Tract Microbiota on Cardiovascular Health and Pathophysiology

Akyıldız

Biondi-Zoccai

Biase

2022

Journal of Cardiovascular Pharmacology

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:The microbiota of the gastrointestinal tract (GIT) is an extremely diverse community of microorganisms, and their collective genomes (microbiome) provide a vast arsenal of biological activities, particularly enzymatic ones, which are far from being fully elucidated. The study of the microbiota (and the microbiome) is receiving great interest from the biomedical community because it carries the potential to improve risk prediction models, refine primary and secondary prevention efforts, and also design more appropriate and personalized therapies, including pharmacological ones. A growing body of evidence, although sometimes impaired by the limited number of subjects involved in the studies, suggests that GIT dysbiosis, that is, the altered microbial composition, has an important role in causing and/or worsening cardiovascular disease (CVD). Bacterial translocation and the alteration of levels of microbe-derived metabolites can thus be important to monitor and modulate because they may lead to initiation and progression of CVD and to its establishment as chronic state. We hereby aim to provide readers with details on available resources and experimental approaches that are used in this fascinating field of biomedical research and on some novelties on the impact of GIT microbiota on CVD.

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“…Previous studies demonstrated the benefits of adding grape extract polyphenols to a mix of L-Arg, L-Thr and L-Gln in terms of gut permeability 26 and amino acid ileal digestibility 27 for broilers under stress. In particular, the use of AA in combination with polyphenols might represent an effective association because of (i) their separate beneficial effects on the gut microbiota and epithelium 28 and (ii) through the binding of AA to tannins, ensuring a protection to AA degradation in the upper side of the digestive tract 29 . Thereby, a supplementation of arginine (Arg), glutamine (Gln) and threonine (Thr) together with grape extract (combination provided at 0.1%) was shown to reverse gut leakage and inflammation under glucocorticoid challenge 26 and coccidian challenge 30 and was equally effective than the inclusion of Arg alone at high level (0.5%) 26 .…”

Section: Introductionmentioning

confidence: 99%

Effect of diet supplemented with functional amino acids and polyphenols on gut health in broilers subjected to a corticosterone-induced stress

Yvon,

Beaumont,

Dayonnet

et al. 2024

Sci Rep

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To address the overuse of antimicrobials in poultry production, new functional feed ingredients, i.e. ingredients with benefits beyond meeting basic nutritional requirements, can play a crucial role thanks to their prophylactic effects. This study evaluated the effects of the supplementation of arginine, threonine and glutamine together with grape polyphenols on the gut integrity and functionality of broilers facing a stress condition. 108 straight-run newly hatched Ross PM3 chicks were kept until 35 days and were allocated to 3 treatments. Broilers in the control group were raised in standard conditions. In experimental groups, birds were administered with corticosterone in drinking water (CORT groups) to impair the global health of the animal and were fed a well-balanced diet supplemented or not with a mix of functional amino acids together with grape extracts (1 g/kg of diet—CORT + MIX group). Gut permeability was significantly increased by corticosterone in non-supplemented birds. This corticosterone-induced stress effect was alleviated in the CORT + MIX group. MIX supplementation attenuated the reduction of crypt depth induced by corticosterone. Mucin 2 and TNF-α gene expression was up-regulated in the CORT + MIX group compared to the CORT group. Caecal microbiota remained similar between the groups. These findings indicate that a balanced diet supplemented with functional AA and polyphenols can help to restore broiler intestinal barrier after a stress exposure.

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Interference of dietary polyphenols with potentially toxic amino acid metabolites derived from the colonic microbiota

Cited by 13 publications

References 107 publications

Maternal amoxicillin affects piglets colon microbiota: microbial ecology and metabolomics in a gut model

Maternal amoxicillin affects piglets colon microbiota: microbial ecology and metabolomics in a gut model

Impact of the Gastrointestinal Tract Microbiota on Cardiovascular Health and Pathophysiology

Effect of diet supplemented with functional amino acids and polyphenols on gut health in broilers subjected to a corticosterone-induced stress

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