Interference in the Measurement of Plasma 11-Hydroxycorticosteroids Caused by Spironolactone Administration

Wood, Lawrence C.; Richards, R H; Ingbar, Sidney H.

doi:10.1056/nejm197003192821204

Cited by 10 publications

(2 citation statements)

References 16 publications

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“…In other studies the duration of the spironolactone effect has varied from 1 to 12 days after discontinuing the drugY, 19 This discrepancy probably reflects differences in dosage and duration of treatment, the plasma level of spiro-nolactone and its metabolites when the drug is discontinued, and the presence or absence of renal or hepatic dysfunction. In other studies the duration of the spironolactone effect has varied from 1 to 12 days after discontinuing the drugY, 19 This discrepancy probably reflects differences in dosage and duration of treatment, the plasma level of spiro-nolactone and its metabolites when the drug is discontinued, and the presence or absence of renal or hepatic dysfunction.…”

Section: Discussionmentioning

confidence: 96%

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Spironolactone and plasma cortisol

Dumlao

Kannan

Krauss

et al. 1973

Clin Pharma and Therapeutics

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Spironolactone has been shown to interfere with the determination of corticosteroids in plasma and urine. In the present study the fluorimetric method of Mattingly was used to determine how rapidly the spurious elevation of plasma cortisol develops after spironolactone administration and to define the rate of disappearance of the artifact from plasma. In normal subjects plasma cortisol levels increased by more than 100% 60 minutes after a single 50 mg oral dose of spironolactone. The maximal concentration of plasma cortisol was observed at 2 hours and the level slowly declined thereafter, reaching pretreatment values 72 hours after administration of the drug.

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Section: Discussionmentioning

confidence: 96%

“…Spironolactone (Aldactone) is associated with an elevation of plasma corti-sol11 , 12,14,19 as measured by the Mattingly technique. 13 This change in plasma cortisol is artifactual and does not represent increased adrenal secretion.…”

mentioning

confidence: 99%

Spironolactone and plasma cortisol

Dumlao

Kannan

Krauss

et al. 1973

Clin Pharma and Therapeutics

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Blood "Cortisol" Levels From Spironolactone

Tashima¹

1973

JAMA

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Non-interaction of spironolactone medication and cortisol metabolism in man

1978

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In 5 healthy subjects and in 5 patients with decompensated liver diseases, the concentrations of cortisol, canrenone and canrenoate-K were determined after single doses and after a long-term treatment with spironolactone. The concentrations of the metabolites of spironolactone were determined fluorimetrically, those of cortisol by a highly specific radioimmunoassay with previous chromatographic separation. As a result, non-interaction between spironolactone medication and cortisol metabolism, even at high dose and long-term treatment conditions, was established neither in normal test subjects nor in patients with liver failure.

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Interference in the Measurement of Plasma 11-Hydroxycorticosteroids Caused by Spironolactone Administration

Cited by 10 publications

References 16 publications

Spironolactone and plasma cortisol

Spironolactone and plasma cortisol

Blood "Cortisol" Levels From Spironolactone

Non-interaction of spironolactone medication and cortisol metabolism in man

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