Interference effect of epigallocatechin-3-gallate on targets of nuclear factor κB signal transduction pathways activated by EB virus encoded latent membrane protein 1

Zhao, Yan; Tao, Yongguang; Feijun, Luo; Tang, Faqing; Tang, Min; Cao, Yang

doi:10.1016/j.biocel.2003.10.024

Cited by 25 publications

(18 citation statements)

References 16 publications

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“…This is corroborated with previously published data, showing the inhibitory effect of EGCG on the migration of the p65 subunit mediated by the Epstein-Barr (EB) virus latent membrane protein (LMP)-1. In addition, the authors reported an increase of NF-kB activity which was attributed to a rise in IKKα expression (Yan et al, 2004). Two models have been proposed for EGCG's activity on NF-kB.…”

Section: Discussionmentioning

confidence: 99%

Epigallocatechin-3-gallate Inhibits Tax-dependent Activation of Nuclear Factor Kappa B and of Matrix Metalloproteinase 9 in Human T-cell Lymphotropic Virus-1 Positive Leukemia Cells

Harakeh¹,

Diab‐Assaf²,

Azar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Epigallocatechin-3-gallate Inhibits Tax-dependent Activation of Nuclear Factor Kappa B and of Matrix Metalloproteinase 9 in Human T-cell Lymphotropic Virus-1 Positive Leukemia Cells

Harakeh¹,

Diab‐Assaf²,

Azar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…CNE1 is an LMP1-negative NPC cell line and CNE1-LMP1 is a stable LMP1-integrated cell line [44]. HNE2 is an LMP1-negative NPC cell line, and HNE2-LMP1 is a cell line that constitutively expresses LMP1 after the introduction of full-length LMP1 cDNA [45].…”

Section: Methodsmentioning

confidence: 99%

EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma

Yang

Liu

et al. 2015

Oncotarget

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LMP1, which is encoded by the Epstein-Barr virus, is proposed to be one of the major oncogenic factors involved in nasopharyngeal carcinoma (NPC). Previous studies demonstrated that down-regulation of LMP1 by LMP1-targeted DNAzyme (DZ1) increases the radiosensitivity of NPC. However, the mechanism by which DZ1 contributes to this radiosensitivity remains unclear. In this study, we determined whether a DZ1 blockade of LMP1 expression has an overall positive effect on the radiotherapy of NPCs by repressing HIF-1/VEGF activity and to investigate the mechanisms underlying LMP1-induced HIF-1 activation in NPC cells. The results showed that DZ1 inhibited the microtubule-forming ability of HUVECs co-cultured with NPC cells, which occurs with the down-regulation of VEGF expression and secretion. Moreover, LMP1 increases phosphorylated JNKs/c-Jun signaling, which is involved in the regulation of HIF-1/VEGF activity. After silencing LMP1 and decreasing phosphorylation of JNKs, NPC cells exhibited an enhanced radiosensitivity. Furthermore, in vivo experiments revealed a significant inhibition of tumor growth and a marked reduction of the Ktrans parameter, which reflects the condition of tumor micro-vascular permeability. Taken together, our data suggested that VEGF expression is increased by LMP1 through the JNKs/c-Jun signaling pathway and indicated that DZ1 enhances the radiosensitivity of NPC cells by inhibiting HIF-1/VEGF activity.

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“…Human nasopharyngeal carcinoma (NPC) cell lines CNE1 (well-differentiated) and HNE2 (poorly-differentiated) stably expressing EBV-encoded LMP1 were provided by Xiangya Central Experiment Laboratory (Changsha, China), which were established by the introduction of full-length LMP1 cDNA into LMP1-negative CNE1 and HNE2 wild cells, respectively [15][16][17][18][19][20][21]. The LMP1 expression was confirmed by western blotting (anti-EBV LMP1 antibody, Abcam Corp., Cambridge, UK).…”

Section: Cell Culturementioning

confidence: 99%

Blockage of LMP1-modulated store-operated Ca2+ entry reduces metastatic potential in nasopharyngeal carcinoma cell

Wei

Zhang

et al. 2015

Cancer Letters

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Interference effect of epigallocatechin-3-gallate on targets of nuclear factor κB signal transduction pathways activated by EB virus encoded latent membrane protein 1

Cited by 25 publications

References 16 publications

Epigallocatechin-3-gallate Inhibits Tax-dependent Activation of Nuclear Factor Kappa B and of Matrix Metalloproteinase 9 in Human T-cell Lymphotropic Virus-1 Positive Leukemia Cells

Epigallocatechin-3-gallate Inhibits Tax-dependent Activation of Nuclear Factor Kappa B and of Matrix Metalloproteinase 9 in Human T-cell Lymphotropic Virus-1 Positive Leukemia Cells

EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma

Blockage of LMP1-modulated store-operated Ca2+ entry reduces metastatic potential in nasopharyngeal carcinoma cell

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