Interference by acetaminophen in the glucose oxidase-peroxidase method for blood glucose determination.

Kaufmann-Raab, I.; Jonen, H. G.; Jähnchen, E.; Kahl, Georg F.; Groth, Ulrich

doi:10.1093/clinchem/22.10.1729

Cited by 26 publications

(10 citation statements)

References 5 publications

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“…19 The oxidation by acetaminophen is thought to be related to the free phenolic hydroxyl group present in acetaminophen. 20 Acetaminophen can cause positive interference with electrochemical glucose test strips and a whole blood analyzer. 15,[20][21][22] In the present study, the devices that use 3 electrodes (ie, Precision G and Precision QID) seemed to overcompensate for the interfering current, especially at the high glucose level.…”

Section: Interference Trends and Their Mechanismsmentioning

confidence: 99%

“…20 Acetaminophen can cause positive interference with electrochemical glucose test strips and a whole blood analyzer. 15,[20][21][22] In the present study, the devices that use 3 electrodes (ie, Precision G and Precision QID) seemed to overcompensate for the interfering current, especially at the high glucose level. With photometry methods, the mechanism of dopamine [4-(2-aminoethyl) brenzcatechin-HCl] interference is assumed to be an inhibition of the chemical reaction on the test strips.…”

Section: Interference Trends and Their Mechanismsmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Drugs on Glucose Measurements With Handheld Glucose Meters and a Portable Glucose Analyzer

Tang

Louie

et al. 2000

American Journal of Clinical Pathology

200

145

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Thirty drugs used primarily in critical care and hospital settings were tested in vitro to observe interference on glucose measurements with 6 hand-held glucose meters and a portable glucose analyzer. Paired differences of glucose measurements between drug-spiked samples and unspiked control samples were calculated to determine bias. A criterion of +/- 6 mg/dL was used as the cutoff for interference. Ascorbic acid interfered with the measurements on all glucose devices evaluated. Acetaminophen, dopamine, and mannitol interfered with glucose measurements on some devices. Dose-response relationships help assessment of drug interference in clinical use. High dosages of these drugs may be given to critically ill patients or self-administered by patients without medical supervision. Package inserts for the glucose devices may not provide adequate warning information. Hence, we recommend that clinicians choose glucose devices carefully and interpret results cautiously when glucose measurements are performed during or after drug interventions.

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Section: Interference Trends and Their Mechanismsmentioning

confidence: 99%

Section: Interference Trends and Their Mechanismsmentioning

confidence: 99%

Effects of Drugs on Glucose Measurements With Handheld Glucose Meters and a Portable Glucose Analyzer

Tang

Louie

et al. 2000

American Journal of Clinical Pathology

200

145

View full text Add to dashboard Cite

show abstract

“…General anesthesia cannot take place without the administration of drugs. Multiple drugs, such as acetaminophen, dopamine and mannitol are known to increase or decrease POCT BG readings, depending on the type of device that is used [17][18][19][20]. In our hospital, acetaminophen is used as premedication.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Accu Chek Inform II point-of-care test blood glucose meter with Hexokinase Plasma method for a diabetes mellitus population during surgery under general anesthesia

Lascaris

Freling

Edens

et al. 2021

J Clin Monit Comput

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Purpose Blood glucose (BG) concentrations of patients with diabetes mellitus (DM) are monitored during surgery to prevent hypo- and hyperglycemia. Access to point-of-care test (POCT) glucose meters at an operating room will usually provide monitoring at shorter intervals and may improve glycemic control. However, these meters are not validated for patients under general anesthesia. Methods This cross-sectional study included 75 arterial BG measurements from 75 patients (71 with DM, mostly insulin dependent) who underwent elective non-cardiac surgery under general anesthesia. Arterial blood samples were taken at least 60 minutes after induction. One drop of blood was used for Accu Chek Inform II (ACI II) POCT BG meter and the residual blood was sent to the clinical laboratory for a Hexokinase Plasma reference method. A Bland–Altman plot was used to visualize the differences between both methods, and correlation was assessed using the intra-class correlation coefficient (ICC). Results The results showed an estimated mean difference of 0.8 mmol/L between ACI II and the reference method, with limits of agreement equal to -0.6 and 2.2 mmol/L. In general, the reference method produced higher values than ACI II. ICC was 0.955 (95% CI 0.634–0.986), P < 0.001, and concordance correlation coefficient (CCC) was 0.955 (95% CI 0.933–0.970). Conclusion Arterial BG measurements during surgery in patients with DM under general anesthesia using POCT BG meter are in general lower than laboratory measurements, but the ICC and CCC show a clinically acceptable correlation. We conclude that POCT measurements conducted on arterial specimens using the ACI II provide sufficiently accurate results for glucose measurement during surgery under general anesthesia.

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“…A common example, acetaminophen, contains a free phenolic hydroxyl group which is considered responsible for acetaminophen oxidation resulting in interference of sensor electrodes. 10,11 Such interference would significantly compromise performance and safety of a closed-loop system where algorithms rely on sensor inputs.…”

Section: Interference Of Insulin Delivery With Colocalized Glucose Sementioning

confidence: 99%

Moving Toward a Unified Platform for Insulin Delivery and Sensing of Inputs Relevant to an Artificial Pancreas

Graf

McAuley

Sims

et al. 2016

J Diabetes Sci Technol

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Advances in insulin pump and continuous glucose monitoring technology have primarily focused on optimizing glycemic control for people with type 1 diabetes. There remains a need to identify ways to minimize the physical burden of this technology. A unified platform with closely positioned or colocalized interstitial fluid glucose sensing and hormone delivery components is a potential solution. Present challenges to combining these components are interference of glucose sensing from proximate insulin delivery and the large discrepancy between the life span of current insulin infusion sets and glucose sensors. Addressing these concerns is of importance given that the future physical burden of this technology is likely to be even greater with the ongoing development of the artificial pancreas, potentially incorporating multiple hormone delivery, glucose sensing redundancy, and sensing of other clinically relevant nonglucose biochemical inputs.

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Interference by acetaminophen in the glucose oxidase-peroxidase method for blood glucose determination.

Cited by 26 publications

References 5 publications

Effects of Drugs on Glucose Measurements With Handheld Glucose Meters and a Portable Glucose Analyzer

Effects of Drugs on Glucose Measurements With Handheld Glucose Meters and a Portable Glucose Analyzer

Comparison of Accu Chek Inform II point-of-care test blood glucose meter with Hexokinase Plasma method for a diabetes mellitus population during surgery under general anesthesia

Moving Toward a Unified Platform for Insulin Delivery and Sensing of Inputs Relevant to an Artificial Pancreas

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