Interfacing Gelatin with (Hydr)oxides and Metal Nanoparticles: Design of Advanced Hybrid Materials for Biomedical Engineering Applications

Engineering of Metal–Organic Frameworks/Gelatin Hydrogel Composites Mediated by the Coacervation Process for the Capture of Acetic Acid

“…In a mammalian gelatin, every third amino acid is thus glycine (Gly), while Xaa is often proline and Yaa is mostly hydroxyproline (Hyp) or alanine (Ala). , Therefore, cluster models that mimic the surfaces of UiO-66 and UiO-66-(CF 3 ) 2 were put into contact with either a Gly-Pro or Gly-Ala dipeptide sequence (Figure S34). The termination scheme of these cluster models cleaved from the periodic DFT-optimized bulk structures involves the capping of the Zr atoms by the OH group .…”

“…These MOF/G hydrogel composites consist presumably of MOF particles distributed in physically cross-linked gelatin gels that can be described as an entangled assembly of rigid triple helices connected by flexible links. Indeed, the sol–gel transition of gelatin and thus the partial renaturation of collagen triple helices is likely to take place during the coacervation process by decreasing the temperature. , The presence and relative quantification of gelatin triple helices in the composites was thus determined by differential scanning calorimetry (DSC). For the whole series, the DSC thermograms (Figure S16a,b) are characterized by a broad endothermic peak corresponding to two superimposed phenomena related to the water vaporization and the melting of gelatin triple helices.…”

“…Gelatin is one of the most commonly used protein biopolymers in industry for drugs and cosmetics microencapsulation because of its low cost, biodegradability, nontoxicity, and renewability . Its combination with a wide range of inorganic materials including (hydr)­oxides, hydroxyapatite, clays, zeolites, and metals was mainly explored for regenerative medicine, drug vectorization, or biosensing. , Gelatin was also shown to exert a remarkable control over the nucleation and growth of biogenic inorganic materials such as fluoroapatite mesocrystals . Such ability of gelatin for morphogenesis in soft conditions was mainly ascribed to its self-organization properties into triple helices and the existence of attractive interactions at the fluoroapatite/gelatin interface.…”