Interfacing an aspiration ion mobility spectrometer to a triple quadrupole mass spectrometer

Adamov, Alexey; Viidanoja, Jyrki; Kärpänoja, Esko; Paakkanen, Heikki; Ketola, Raimo A.; Kostiainen, Risto; Сысоев, А. А.; Kotiaho, Tapio

doi:10.1063/1.2723742

Cited by 21 publications

(17 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pedersen et al used DTBP as an internal standard to minimize the influence of temperature, pressure, and electrical field in the characterization of proton-bound acetate dimers 33. DTBP also has been used to correct mobilities in IMS34 and to demonstrate the performance of ion mobility spectrometers coupled to mass spectrometers 35,36…”

Section: Introductionmentioning

confidence: 99%

Chemical standards in ion mobility spectrometry

Fernandez‐Maestre

Harden

Ewing

et al. 2010

Analyst

103

View full text Add to dashboard Cite

In ion mobility spectrometry (IMS), reduced mobility values (K0) are used as a qualitative measure of gas phase ions, and are reported in the literature as absolute values. Unfortunately, these values do not always match those collected in the field. One reason for this discrepancy is that the buffer gas may be contaminated with moisture or other volatile compounds. In this study, the effect of moisture and organic contaminants in the buffer gas on the mobility of IMS standards and analytes was investigated for the first time using IMS directly coupled to mass spectrometry. 2,4-dimethylpyridine, 2,6-di-tert-butyl pyridine (DTBP), and tetrabutylammonium, tetrapropylammonium, tetraethylammonium, and tetramethylammonium chlorides were used as chemical standards. In general, the mobility of IMS standard product ions was not affected by small amounts of contamination while the mobilities of many analytes were affected. In the presence of contaminants in the buffer gas, the mobility of analyte ions is often decreased by forming ionmolecule clusters with the contaminant. To ensure the measurement of accurate reduced mobility values, two IMS standards are required: an instrument and a mobility standard. An instrument standard is not affected by contaminants in the buffer gas, and provides an accurate measurement of the instrumental parameters, such as voltage, drift length, pressure, and temperature. The mobility standard behaves like an analyte ion in that the compound's mobility is affected by low levels of contamination in the buffer gas. Prudent use of both of these standards can lead to improved measurement of accurate reduced mobility values.

show abstract

Section: Introductionmentioning

confidence: 99%

Chemical standards in ion mobility spectrometry

Fernandez‐Maestre

Harden

Ewing

et al. 2010

Analyst

103

View full text Add to dashboard Cite

show abstract

“…Other related IMS methods, high-field asymmetric waveform ion mobility spectrometry [24] and traveling waveform ion mobility spectrometry [25] have been coupled to time-of-flight mass spectrometers and shown to provide some degree of resolution between carbohydrate isomers. IMS can also be readily interfaced with other types of mass spectrometers, such as quadrupoles [26], triple quadrupoles [27], quadrupole ion traps [28], and FTICR [29] mass spectrometers. Previous studies using a two-gate IMS system have shown that collision-induced dissociation (CID) MS/MS spectra could be acquired after selectively introducing ions based on mobility into a quadrupole ion trap [28] or an ICR cell [29], although in these studies no sets of isomeric oligosaccharides were investigated.…”

Section: Introductionmentioning

confidence: 99%

Ion mobility-mass spectrometry analysis of isomeric carbohydrate precursor ions

et al. 2009

View full text Add to dashboard Cite

The rapid separation of isomeric precursor ions of oligosaccharides prior to their analysis by MSn was demonstrated using an ambient pressure ion mobility spectrometer (IMS) interfaced with a quadrupole ion trap. Separations were not limited to specific types of isomers; representative isomers differing solely in the stereochemistry of sugars, in their anomeric configurations, and in their overall branching patterns and linkage positions could be resolved in the millisecond time frame. Physical separation of precursor ions permitted independent mass spectra of individual oligosaccharide isomers to be acquired to at least MS3, the number of stages of dissociation limited only practically by the abundance of specific product ions. IMS-MSn analysis was particularly valuable in the evaluation of isomeric oligosaccharides that yielded identical sets of product ions in MS/MS experiments, revealing pairs of isomers that would otherwise not be known to be present in a mixture if evaluated solely by MS dissociation methods alone. A practical example of IMS-MSn analysis of a set of isomers included within a single HPLC fraction of oligosaccharides released from bovine submaxillary mucin is described.

show abstract

“…The combination of AIMS and quadrupole MS has been reported. This combined instrument is useful to gather fundamental information concerning the functionality of AIMS instrument (Adamov et al, 2007). The principle of FAIMS and its application to MS has been extensively reviewed (Guevremont, 2004a).…”

Section: Spectrometry For Explosivesmentioning

confidence: 99%

Ion spectrometric detection technologies for ultra‐traces of explosives: A review

Mäkinen

Nousiainen

Sillanpää

2011

Mass Spectrometry Reviews

146

102

View full text Add to dashboard Cite

In recent years, explosive materials have been widely employed for various military applications and civilian conflicts; their use for hostile purposes has increased considerably. The detection of different kind of explosive agents has become crucially important for protection of human lives, infrastructures, and properties. Moreover, both the environmental aspects such as the risk of soil and water contamination and health risks related to the release of explosive particles need to be taken into account. For these reasons, there is a growing need to develop analyzing methods which are faster and more sensitive for detecting explosives. The detection techniques of the explosive materials should ideally serve fast real-time analysis in high accuracy and resolution from a minimal quantity of explosive without involving complicated sample preparation. The performance of the in-field analysis of extremely hazardous material has to be user-friendly and safe for operators. The two closely related ion spectrometric methods used in explosive analyses include mass spectrometry (MS) and ion mobility spectrometry (IMS). The four requirements-speed, selectivity, sensitivity, and sampling-are fulfilled with both of these methods.

show abstract

Interfacing an aspiration ion mobility spectrometer to a triple quadrupole mass spectrometer

Cited by 21 publications

References 33 publications

Chemical standards in ion mobility spectrometry

Chemical standards in ion mobility spectrometry

Ion mobility-mass spectrometry analysis of isomeric carbohydrate precursor ions

Ion spectrometric detection technologies for ultra‐traces of explosives: A review

Contact Info

Product

Resources

About