“…Total drug and metabolites were determined by heating the acidified urine for 2 hr a t 100' before extraction, derivatization, and chromatography3. Metabolites were synthesized as reported earlier (1,4).…”
Section: Srikumaran Melethil * and Walter D Conwaymentioning
“…Total drug and metabolites were determined by heating the acidified urine for 2 hr a t 100' before extraction, derivatization, and chromatography3. Metabolites were synthesized as reported earlier (1,4).…”
Section: Srikumaran Melethil * and Walter D Conwaymentioning
“…Various methods have been described in the literature as approaches to the stabilization of suspension systems involving rheological control or flocculation. One method involved coating of the insoluble particles to nullify the surface charges, after which they are flocculated under controlled conditions and suspended in a non-ionic vehicle (2)(3)(4)(5). The reduction of the insoluble particle to a very fine particle size and the adjustment of the vehicle density (6, 7) is another.…”
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