Interfacial Interactions and Nanostructure Changes in DPPG/HD Monolayer at the Air/Water Interface

Zhu, Huaxin; Sun, Run‐Cang; Zhang, Tao; Hao, Changchun; Zhang, Pengli; Wang, Juan; Li, Shaorong

doi:10.1155/2015/908585

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…From the values of Δ G ex , the interaction parameter ξ and activity coefficients γ i of DPPC and CUR at a given surface pressure can be calculated by the following equations [ 23 , 34 , 35 ]:

where R is the Boltzmann constant, T is the absolute temperature, and X 1 and X 2 denote the mole fractions of components 1 and 2 in the mixed film. The interaction parameter ξ is a measurement of the cohesive forces between different molecules [ 36 , 37 ]. The negative value of ξ denotes a stronger attractive interaction between the two molecules while the positive value of ξ means a stronger repulsive interaction between like molecules [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Investigation of Surface Behavior of DPPC and Curcumin in Langmuir Monolayers at the Air-Water Interface

Hao

Zhang

et al. 2017

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Langmuir monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and a mixture of DPPC with curcumin (CUR) have been investigated at the air-water interface through a combination of surface pressure measurements and atomic force microscopy (AFM) observation. By analyzing the correlation data of mean molecular areas, the compressibility coefficient, and other thermodynamic parameters, we obtained that the interaction between the two components perhaps was mainly governed by the hydrogen bonding between the amino group of DPPC and the hydroxyl groups of CUR. CUR markedly affected the surface compressibility, the thermodynamic stability, and the thermodynamic phase behaviors of mixed monolayers. The interaction between CUR and DPPC was sensitive to the components and the physical states of mixed monolayers under compression. Two-dimensional phase diagrams and interaction energies indicated that DPPC and CUR molecules were miscible in mixed monolayers. AFM images results were in agreement with these analyses results of experimental data. This study will encourage us to further research the application of CUR in the biomedical field.

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Section: Resultsmentioning

confidence: 99%

Investigation of Surface Behavior of DPPC and Curcumin in Langmuir Monolayers at the Air-Water Interface

Hao

Zhang

et al. 2017

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“…The effect of different concentrations of various carbon nanomaterials on the lipid layer may be assessed by qualitative comparison of the shape of π-A isotherm curves; however, a more articulate information on mechanical effects in the monolayer can be gathered from surface compressibility functions. Isothermal surface compressibility κ is a reciprocal of dilatational elasticity of the interfacial region ε (sometimes also called the compressibility modulus C s −1 [22]):…”

Section: Experimental Techniques and Data Analysismentioning

confidence: 99%

Interactions of Carbon Nanotubes and Carbon Nanohorns with a Model Membrane Layer and Lung Surfactant In Vitro

Kondej

Sosnowski

2019

Journal of Nanomaterials

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A broader use of carbon nanomaterials increases the risk of their inhalation as aerosol dispersed in the air. Inhaled nanometer-sized particles are known to penetrate to the pulmonary region where they interact with the lung surfactant as the first barrier they meet and eventually penetrate to the surface of the cellular layer. This study presents the results of experimental studies of physicochemical interactions between several types of carbon nanomaterials (nanotubes and nanohorns of various size and surface properties) and lipid layers in two qualitatively different experimental systems: Langmuir trough and pulsated drop tensiometer, both providing complementary possibilities to study interfacial properties of the lipid-rich layer. Quantified alterations in mechanical properties if lipid films (equilibrium compressibility, dynamic surface elasticity, and viscosity) indicate that nanocarbons with different wettability may induce concentration-dependent frustration of the lung surfactant and biological membranes in vivo. The observed effects are discussed not only in relation to health effects from nanoparticle inhalation but also to potential medical applications of engineered carbon nanomaterials.

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“…Simplified lipid model systems were applied to study the details of membrane affinity of the bioactive compounds. The Langmuir monolayer of lipid molecules is a widely used membrane model due to its well defined and controlled structure as well as versatility in composition [12][13][14][15][16][17][18][19]. The molecular interaction with dissolved drug component is monitored by the increase of surface pressure allowing to deduce its penetration ability [20][21][22][23].…”

Section: Tuberculosis (Tb) Is a Bacterial Infection Mainly Caused By mentioning

confidence: 99%

Comparative analysis of new peptide conjugates of antitubercular drug candidates—Model membrane and in vitro studies

Ábrahám

Baranyai²,

Gyulai

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Novel peptide conjugates of two antitubercular drug ca ndidates were s ynthesi s ed a nd cha ra cteri s ed us i ng new tufts i n peptide derivatives (OT14) as carrier moiety. As antitubercular drug ca ndidates two pyridopyrimidine derivatives, TB803 (2-a l lylamino-4-oxopyrido[1,2-a]pyrimidine-3-carbaldehyde) a nd TB820 (4-oxo-2-(pyrroli di n-1-yl )-pyri do[1,2-a ]pyri mi di n-3-ca rba ldehyde) inhibiting vi tal enzyme of Mycobacterium tuberculosis were applied. Membrane affini ty of the compounds TB803 a nd TB820 a nd their peptide conjugates wa s eva l ua ted us i ng experi menta l l i pi d mono -a nd bi l a yer model s . Penetration ability was assessed tensiometrically from La ngmuir monolayer study a nd a pplying quartz crys tal microbalance for the s upported l ipid bilayer (SLB) system. Mi nimal inhibitory concentration (MIC) values remained in a similar micromolar ra nge for both of the conjugates whi l e thei r cel l ul a r upta k e ra te wa s i mproved s i gni fi ca ntl y compa red to the drug ca ndidates. A correlation was found between membrane affinity properties a nd results of in vitro bi ological i nvestiga ti ons . Ana l ysis of physical/structural properties of SLB in contact with bioactive components and vi s ua l i za ti on of the s tructura l cha nge by a tomic-force microscopy (AFM) provi ded i nformation on the type and route of mol ecul a r i ntera cti on of drug cons truction with lipid l ayers. The possible role of electrostatic i nteractions between lipid layer a nd drug ca ndi da tes wa s tes ted in Langmuir-balance experiments using nega ti vel y cha rged l i pi d mi xture (DPPC+DPPG). Es peci a l l y the pepti de conjugates presented i ncreased membrane affinity due to ca tionic cha ra cter of the pepti de s equence s el ected for the conjugate formation. That is supposed to be one reason for the enhanced cellular uptake observed in vitro for MonoMa c6 cel l line. The conjugation of a ntitubercular a gents to a peptidic ca rrier i s a promi s i ng a pproa ch to enha nce membra ne a ffi ni ty, cel l ul a r upta ke ra te a nd in vitro s el ecti vi ty.

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Interfacial Interactions and Nanostructure Changes in DPPG/HD Monolayer at the Air/Water Interface

Cited by 4 publications

References 39 publications

Investigation of Surface Behavior of DPPC and Curcumin in Langmuir Monolayers at the Air-Water Interface

Investigation of Surface Behavior of DPPC and Curcumin in Langmuir Monolayers at the Air-Water Interface

Interactions of Carbon Nanotubes and Carbon Nanohorns with a Model Membrane Layer and Lung Surfactant In Vitro

Comparative analysis of new peptide conjugates of antitubercular drug candidates—Model membrane and in vitro studies

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