Interfacial instability at cell membranes

Gallez, Dominique; Coakley, W. Terence

doi:10.1016/0079-6107(86)90011-8

Cited by 63 publications

(30 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 (10,(13)(14)(15)(16), especially when we take into account that the electron micrographs need not show the most distinctive mirror-plane cross-section. Our numerically predicted sigmoid-contact shape is remarkably similar to the observed large-scale doublet structure even in cases where the membranes are not contiguous along the contact zone because of the instability attributable to the intermembrane water layer (40).…”

Section: Discussionsupporting

confidence: 60%

Flat and sigmoidally curved contact zones in vesicle–vesicle adhesion

Ziherl

Svetina

2007

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Using the membrane-bending elasticity theory and a simple effective model of adhesion, we study the morphology of lipid vesicle doublets. In the weak adhesion regime, we find flat-contact axisymmetric doublets, whereas at large adhesion strengths, the vesicle aggregates are nonaxisymmetric and characterized by a sigmoidally curved, S-shaped contact zone with a single invagination and a complementary evagination on each vesicle. The sigmoid-contact doublets agree very well with the experimentally observed shapes of erythrocyte aggregates. Our results show that in identical vesicles with large to moderate surface-to-volume ratio, the sigmoid-contact shape is the only bound morphology. We also discuss the role of sigmoid contacts in the formation of multicellular aggregates such as erythrocyte rouleaux.lipid vesicle ͉ vesicle doublet ͉ sigmoid-contact doublet ͉ rouleau E lastic theory of shapes of phospholipid vesicles (1) is a very successful model. Its phase diagram, now explored in considerable detail, comprises a broad spectrum of shapes such as stomatocytes, discocytes, dumbbells, pears, torocytes, starfish, rackets, etc. (2-5). A large majority of the predicted shapes has been observed experimentally (6), and some of them correspond very closely to the different normal and abnormal forms of a mammalian erythrocyte, a simple anucleate eukaryotic cell. If the theory is extended to include the shear elasticity of the membrane skeleton, the agreement between the calculated and the actual shapes is truly striking, even in very deformed erythrocytes such as echinocytes (7).These results give hope that the approach can be extended to describe not only single vesicles but also their aggregates. With some exceptions, theoretical studies of aggregates rely on the simplest model of the intermembrane attraction where the adhesion energy is proportional to the contact area (8-10). In the first analyses of erythrocyte doublets and rouleaux, the contact zone was assumed to be flat (10-12), but at large adhesion strengths, this hypothesis was found to disagree with experiments (10); so far no explanation of the observed shapes has been available.Here we fill this gap by studying vesicle-vesicle adhesion within a fully numerical model free of all symmetry constraints, and we focus on vesicle doublets as the most elementary aggregates. Our central result is a doublet morphology with a sigmoid shape of the contact zone, which closely reproduces the large-scale features of erythrocyte doublets (10-16). In vesicles of volume and area of a human erythrocyte, this doublet is the stable shape at large enough adhesion strengths, whereas immediately beyond the aggregation threshold, a flat-contact doublet is found. We show that with increasing surface-to-volume ratio, the range of adhesion strengths corresponding to the flat-contact doublet should diminish and eventually vanish, leaving the sigmoid-contact doublet as the only stable bound morphology. These findings also provide an insight into the mechanics of aggregates of more than ...

show abstract

Section: Discussionsupporting

confidence: 60%

Flat and sigmoidally curved contact zones in vesicle–vesicle adhesion

Ziherl

Svetina

2007

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Consistent with the energy-depletion hypothesis, quite a few recent research papers support an inverse relationship between interfacial water stress and surface energy [201][202][203][204][205][206]. Interfacial waves have been identified by intravital microscopists [207][208][209]. Gallez and Coakley showed empirically that the average number of waves per wavy cell rim decreased when cell surface charge was depleted, and when cationic drugs were present, and increased in the presence of anionic drugs [198,209].…”

Section: Exogenous Interfacial Water Stress As a Short-circuit Energmentioning

confidence: 71%

“…Interfacial waves have been identified by intravital microscopists [207][208][209]. Gallez and Coakley showed empirically that the average number of waves per wavy cell rim decreased when cell surface charge was depleted, and when cationic drugs were present, and increased in the presence of anionic drugs [198,209]. Because of the inverse relationship between wavelength and energy in the classical wave equation, it may be inferred that the spatial distribution of wave-like densities noted on scanning electron micrographs may be produced by the interaction (reflection) of electrons with the structured water at the interface.…”

Section: Exogenous Interfacial Water Stress As a Short-circuit Energmentioning

confidence: 99%

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Davidson¹,

Lauritzen

Seneff

2013

Entropy

View full text Add to dashboard Cite

This paper postulates that water structure is altered by biomolecules as well as by disease-enabling entities such as certain solvated ions, and in turn water dynamics and structure affect the function of biomolecular interactions. Although the structural and dynamical alterations are subtle, they perturb a well-balanced system sufficiently to facilitate disease. We propose that the disruption of water dynamics between and within cells underlies many disease conditions. We survey recent advances in magnetobiology, nanobiology, and colloid and interface science that point compellingly to the crucial role played by the unique physical properties of quantum coherent nanomolecular clusters of magnetized water in enabling life at the cellular level by solving the "problems" of thermal diffusion, intracellular crowding, and molecular self-assembly. Interphase water and cellular surface tension, normally maintained by biological sulfates at membrane surfaces, are compromised by exogenous interfacial water stressors such as cationic aluminum, with consequences that include greater local water hydrophobicity, increased water tension, and interphase stretching. The ultimate result is greater "stiffness" in the extracellular matrix and either the "soft" cancerous state or the "soft" neurodegenerative state within cells. Our hypothesis provides a basis for understanding why so many idiopathic diseases of today are highly stereotyped and pluricausal. OPEN ACCESSEntropy 2013, 15 3823

show abstract

“…However, many other mammalian cultured cells (endothelial cell membrane) with mobile surface receptors (proteins) and cells, fibroblasts, glioma cells) also form specialized adheby the solid support (usually glass) bearing fixed binding sites. Previous work has been done to interpret the periodic patterns observed in adhering red blood cells in terms of interfacial stability theory (21)(22)(23). Our results will be compared with recent experiments on red blood cells adhering to glass in the presence of polycations (24), where periodic patterns (wavelike morphologies) have also been observed, and to receptor-mediated adhesion of cells to ligand-coated surfaces (25,26).…”

Section: Discussionmentioning

confidence: 84%

Dynamics of a Thin Liquid Film with a Surface Chemical Reaction

Gallez

Wit

Kaufman

1996

Journal of Colloid and Interface Science

Self Cite

View full text Add to dashboard Cite

(rupture, shock waves, oscillations, etc.) will depend on the The detailed description of the influence of a chemical reaction geometry of the film. Another important factor influencing on the dynamic behavior of a thin liquid film is of significant the dynamics of the liquid film is the presence of gradients importance in many engineering and biological applications. In of additives (solutal Marangoni effect) or gradients of temthis paper, the dynamics of a thin liquid film on a solid substrate perature (thermal Marangoni effect). If we consider only of T lymphocytes, a major immunological cell type, which requiresIn a preceding paper (11), we compared the stability and the clustering of cell surface receptors by interaction of T-cell receptors with surface-bound ligands. ᭧

show abstract

Interfacial instability at cell membranes

Cited by 63 publications

References 124 publications

Flat and sigmoidally curved contact zones in vesicle–vesicle adhesion

Flat and sigmoidally curved contact zones in vesicle–vesicle adhesion

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Dynamics of a Thin Liquid Film with a Surface Chemical Reaction

Contact Info

Product

Resources

About