Interfacial Bioorthogonal Cross-Linking

Zhang, Han; Dicker, Kevin T.; Xu, Xiaojie; Jia, Xinqiao; Fox, Joseph M.

doi:10.1021/mz5002993

Cited by 62 publications

(83 citation statements)

References 46 publications

(74 reference statements)

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“…Because the crosslinking is diffusion controlled, hydrogel spheres with 3D spatial patterns (Figure 4A) and water-filled hydrogel channels (Figure 4B) can be fabricated readily without the need for external templates or stimuli. 51 These bioorthogonal hydrogel platforms are being explored for the in vitro assembly of secretory acini with interconnected ducts.…”

Section: Biomaterials Strategymentioning

confidence: 99%

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Biomaterials-based strategies for salivary gland tissue regeneration

et al. 2016

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The salivary gland is a complex, secretory tissue that produces saliva and maintains oral homeostasis. Radiation induced salivary gland atrophy, manifested as “dry mouth” or xerostomia, poses a significant clinical challenge. Tissue engineering recently has emerged as an alternative, long-term treatment strategy for xerostomia. In this review, we summarize recent efforts towards the development of functional and implantable salivary glands utilizing designed polymeric substrates or synthetic matrices/scaffolds. Although the in vitro engineering of a complex implantable salivary gland is technically challenging, opportunities exist for multidisciplinary teams to harvest the regenerative potential of stem/progenitor cells found in the adult glands and combine them with biomimetic and cell-instructive materials to assemble implantable tissue modules.

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Section: Biomaterials Strategymentioning

confidence: 99%

“…( G ): Crosshatched multiblock copolymer mesh imaged under light microscope. Reprinted with permission from Zhang et al, 2014 (A–B), 51 Jia et al, 2006 (C), 52 Jha et al, 2009 (D), 56 and Soscia et al, 2013 (E) 28 and Liu et al, 2015 (F–G). 31 …”

Section: Figurementioning

confidence: 99%

Biomaterials-based strategies for salivary gland tissue regeneration

et al. 2016

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“…Another impactful demonstration of the utility of the TCO/Tz reaction in polysaccharide chemistry was performed by the Jia and Fox groups [127]. In this work, the authors took advantage of the rapid reaction between Tz and TCO (rate constant k 2 > 10 5 M -1 s -1 has been measured [128]) to realize rapid diffusion-controlled interface crosslinking ( Figure 17).…”

Section: Inverse Electron Demand Diels-alder Reactionmentioning

confidence: 99%

“…(b) Gel interface forms when a droplet of tetrazine-modified hyaluronic (HA-Tz) contacts a solution of bis-transcyclooctene cross-linker (bis-TCO). Cross-linking at the gel/liquid interface is faster than the rate of diffusion through the gel interface [127],. Copyright 2014.…”

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confidence: 99%

“Click” reactions in polysaccharide modification

Meng

Edgar

2016

Progress in Polymer Science

167

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Polysaccharide chemistry is enjoying accelerating development thanks to advances in synthetic techniques, biochemistry and solvents, which enable polysaccharide materials to be useful in a variety of demanding applications. Among the synthetic advances, click chemistry has reconfigured the realm of polysaccharide modification that previously was dominated by conventional synthetic approaches such as esterification and etherification. "Click" reactions provide mild, modular, and efficient modification pathways, and equally importantly allow us to synthesize derivatives with novel functionality, architecture, and properties, that are otherwise difficult to obtain via conventional methods. Herein, we review application in polysaccharide modification of six groups of click reactions; CuAAC (copper catalyzed alkyne/azide cycloaddition), metal-free [3+2] cycloaddition, Diels-Alder reaction, oxime click, thiol-Michael reaction, and thiol-ene reaction, as well as one click-like reaction that is the subject of our own research, olefin cross-metathesis.

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“…154–157 Pioneered by the Fox group, the Fox and Jia groups subsequently developed the tetrazine ligation for the production of polymers and polymer conjugates. 158 Jia and coworkers further reported the formation of block copolymers by interfacial bioorthogonal polymerization. The multiblock copolymer fibers were obtained by rapid reaction between sTCO and diphenyl-s-tetrazine (GGWGRGDSPG peptide tagged with PEG) PEG derivatives with immiscible liquid-liquid interfaces.…”

Section: Synthetic Strategies For Producing Peptide-polymer Conjugatesmentioning

confidence: 99%

Responsive hybrid (poly)peptide–polymer conjugates

et al. 2017

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(Poly)peptide-polymer conjugates continue to garner significant interest in the production of functional materials given their composition of natural and synthetic building blocks that confer select and synergistic properties. Owing to opportunities to design predefined architectures and structures with different morphologies, these hybrid conjugates enable new approaches for producing micro- or nanomaterials. Their modular design enables the incorporation of multiple responsive properties into a single conjugate. This review presents recent advances in (poly)peptide-polymer conjugates for drug-delivery applications, with a specific focus on the utility of the (poly)peptide component in the assembly of particles and nanogels, as well as the role of the peptide in triggered drug release.

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Interfacial Bioorthogonal Cross-Linking

Cited by 62 publications

References 46 publications

Biomaterials-based strategies for salivary gland tissue regeneration

Biomaterials-based strategies for salivary gland tissue regeneration

“Click” reactions in polysaccharide modification

Responsive hybrid (poly)peptide–polymer conjugates

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