Interfacial behavior of PEGylated lipids and their effect on the stability of squalenoyl-drug nanoassemblies

Bekkara-Aounallah, Fawzia; Ambike, Anshuman A.; Gref, Ruxandra; Couvreur, Patrick; Rosilio, Véronique

doi:10.1016/j.ijpharm.2014.04.072

Cited by 6 publications

(3 citation statements)

References 37 publications

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“…The solution containing SQ-PEG 1500 -NH-Boc was collected from the dialysis tube and was freeze-dried under reduced pressure to obtain a white fluffy solid yielding 196.2 mg (80%). Due to the self-assembly properties of squalene moiety and the amphiphilic nature of the SQ-PEG 1500 -NH-Boc copolymer, in aqueous media, the preparation of SQ-PEG 1500 -NH-Boc unloaded micelles was accomplished by the ultrasound-assisted method, using the protocol published elsewhere [31,60]. The obtained SQ-PEG 1500 -NH-Boc, a white fluffy solid, was solubilized in mQ-H 2 O/PBS at a desired concentration and magnetically stirred for 24 h at ambient temperature (23 • C).…”

Section: Synthesis Of the Sq-peg 1500 -Nh-boc Amphiphilic Copolymermentioning

confidence: 99%

“…The obtained SQ-PEG 1500 -NH-Boc, a white fluffy solid, was solubilized in mQ-H 2 O/PBS at a desired concentration and magnetically stirred for 24 h at ambient temperature (23 • C). It is well known that PEGylated squalene in aqueous media at a concentration close to or higher than CMC is instantly self-assembled into nano-sized micellar architectures with a hydrophobic core surrounded by a hydrophilic shell [60,61]. Also, it is expected that even if the concentration of SQ-PEG 1500 -NH-Boc is less than CMC, the copolymer will be assembled into an intramolecular aggregate when the squalene is surrounded by a PEG moiety [62].…”

Section: Synthesis Of the Sq-peg 1500 -Nh-boc Amphiphilic Copolymermentioning

confidence: 99%

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Novel Nanotherapeutic Systems Based on PEGylated Squalene Micelles for Enhanced In Vitro Activity of Methotrexate and Cytarabine

Craciun,

Sandu,

Peptanariu

et al. 2023

Polymers

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Nanomedicine has garnered significant attention due to the advantages it offers in the treatment of cancer-related disorders, some of the deadliest diseases affecting human lives. Conventional medication formulations often encounter issues of instability or insolubility in biological environments, resulting in low bioavailability. Nanocarriers play a crucial role in transporting and safeguarding drugs at specific sites of action, enabling gradual release under particular conditions. This study focuses on methotrexate (MTx) and cytarabine (Cyt), essential antitumoral drugs, loaded into PEGylated squalene micellar structures to enhance therapeutic effectiveness and minimize drawbacks. The micelles were prepared using ultrasound-assisted methods in both water and phosphate buffer saline solutions. Evaluation of drug-loaded micelles encompassed parameters such as particle size, colloidal stability, surface charge, morphology, encapsulation efficiency, drug loading capacity, and in vitro release profiles under simulated physiological and tumoral conditions. In vitro cell inhibition studies conducted on MCF-7 and HeLa cell lines demonstrated higher antitumoral activity for the drug-encapsulated micelles compared to free drugs. The encapsulation effectively addressed the burst effect, providing sustained release for at least 48 h while enhancing the drug’s protection under physiological conditions.

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Section: Synthesis Of the Sq-peg 1500 -Nh-boc Amphiphilic Copolymermentioning

confidence: 99%

Section: Synthesis Of the Sq-peg 1500 -Nh-boc Amphiphilic Copolymermentioning

confidence: 99%

Novel Nanotherapeutic Systems Based on PEGylated Squalene Micelles for Enhanced In Vitro Activity of Methotrexate and Cytarabine

Craciun,

Sandu,

Peptanariu

et al. 2023

Polymers

View full text Add to dashboard Cite

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“…Zhao et al demonstrated the efficacy of cell penetrable dendrimer as a potential antitumor drug carrier by 5-FU and lysine dendrimer conjugates [188]. Several nanocarriers like PEGylated lipids for squalenoyl amphiphilic prodrugs of gemcitabine and dideoxycytidine [189] and polymeric micelles for stearoyl-gemcitabine [190] are being developed to improve the efficacy and sustainability of the anticancer properties. A glycol chitosan (GC) grafted with 2,3-dimethylmaleic acid (DMA) and fullerene (C60) nanogels display both photo and low pH responsive properties for cancer therapy [191].…”

Section: Prodrug Approach: Analog / Chemical Conjugation For Cancementioning

confidence: 99%

Novel delivery approaches for cancer therapeutics

Mitra

Agrahari

Mandal

et al. 2015

Journal of Controlled Release

130

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Currently, a majority of cancer treatment strategies are based on the removal of tumor mass mainly by surgery. Chemical and physical treatments such as chemo- and radiotherapies have also made a major contribution in inhibiting rapid growth of malignant cells. Furthermore, these approaches are often combined to enhance therapeutic indices. It is widely known that surgery, chemo- and radiotherapy also inhibit normal cells growth. In addition, these treatment modalities are associated with severe side effects and high toxicity which in turn lead to low quality of life. This review encompasses novel strategies for more effective chemotherapeutic delivery aiming to generate better prognosis. Currently, cancer treatment is a highly dynamic field and significant advances are being made in the development of novel cancer treatment strategies. In contrast to conventional cancer therapeutics, novel approaches such as ligand or receptor based targeting, triggered release, intracellular drug targeting, gene delivery, cancer stem cell therapy, magnetic drug targeting and ultrasound-mediated drug delivery, have added new modalities for cancer treatment. These approaches have led to selective detection of malignant cells leading to their eradication with minimal side effects. Lowering, multi-drug resistance and involving influx transportation in targeted drug delivery to cancer cells can also contribute significantly in the therapeutic interventions in cancer.

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