Interface-Engineered Mesoporous FeB with Programmed Drug Release for Synergistic Cancer Theranostics

Abstract

The pursuit of mesoporous Fe-based nanoagents addresses the field of developing alternative Fe-bearing nanoagents for synergistic cancer therapy with the expectation that the use of an essential element may avoid the issues raised by the exogenous administration of other metal element-based nanoagents. Herein, we highlight the interface-engineered mesoporous FeB (mFeB) where the core mFeB is interfacially oxidized into an FeOOH nanosheet loaded with the chemotherapeutic drug doxorubicin (DOX) and further encapsuled within the double-sulfide-bonded SiO 2 outer layer, denoted as mFeB@DOX-ss-SiO 2 , which can realize programmed drug release for synergistic cancer theranostics. When only in a tumor microenvironment, the nanoagent can be activated to release DOX from the mFeB and FeOOH nanosheets as well as expose the easily oxidized mFeB to spontaneously transform to FeOOH nanosheets with Fenton activity to facilitate chemodynamic therapy (CDT).

Ultra‐Efficient Synthesis of Nb4C3Tx MXene via H2O‐Assisted Supercritical Etching for Li‐Ion Battery

“…b = 0.5 implies an ideal diffusion behavior (diffusion‐controlled process), and b = 1 represents a capacitive charge storage mechanism. [ 48,49 ] As shown in Figure 5g, the b values of the cathodic and anodic peaks of the Nb 4 C 3 T x MXene electrode are 0.83 and 0.82, respectively, suggesting that the charge storage mechanism of the Nb 4 C 3 T x electrode is dominated by the capacitive process. The proportion of capacitive and diffusion‐controlled process can be calculated using the following equation: $$$$\begin{equation}i\left( V \right) = {k}_1{v} + {k}_2{v}^{0.5}\end{equation}$$$$where k 1 v represents a capacitive process and k 2 v 0.5 corresponds to a diffusion process.…”

Mesoporous polydopamine delivery system for intelligent drug release and photothermal-enhanced chemodynamic therapy using MnO2 as gatekeeper

“…When they were delivered into tumor sites, the protective layer can be destroyed, which accelerated the release of drugs [ 25 , 26 ]. TME-responsive liposomes [ 27 , 28 ], polypeptides [ 29 ] and inorganic nanomaterials with disulfide bond [ 30 ] could cleave into small nanocomponents by endogenous substances, by which the drugs release was caused. Thermosensitive polymer, a kind of temperature-responsive phase-transition material, can transition from solid into liquid under the triggering of photo-thermal conversion, by which the accelerated drug release and photothermal therapy (PTT) were realized [ 31 , 32 ].…”

Nanostructure engineering of ruthenium-modified electrocatalysts for efficient electrocatalytic water splitting

“…Over the past few decades, many advanced strategies, such as surface/interface engineering, morphology control, defect regulation, and doping, have been exploited to promote the electrocatalytic performance of catalysts. [38][39][40] In terms of Ru-modied electrocatalysts, increasing attention is focused on the strong interaction between metal Ru species and different matrixes, as well as the synergistic catalytic mechanism for overall water splitting. For example, the design of single-atom Ru sites on various carriers can achieve signicantly different catalytic activity and stability.…”