Intérêt du double déclenchement par agoniste de la GnRH et hCG en cas d’antécédent d’immaturité ovocytaire en FIV/ICSI

Herbemont, C.; Kouhen, I. El; Brax, A.; Vinolas, Claire; Dagher-Hayeck, B.; Comtet, Marjorie; Sarandi, S; Grynberg, M.; Cédrin‐Durnerin, Isabelle; Sifer, C.

doi:10.1016/j.gofs.2019.06.012

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…In addition, it is important to note that both study groups exceeded expectations for both CPR and LBR compared with our center’s overall success rate in women <35 years old undergoing fresh autologous ET. This finding correlates with multiple research studies that showed that dual trigger improves IVF outcomes ( 38 , 39 , 40 , 41 , 42 , 43 ). Included in these studies was a double-blind, randomized, controlled trial that showed that the use of dual trigger had a significantly higher number of M2 oocytes retrieved, CPR, and LBR compared with those of hCG only trigger ( 40 ).…”

Section: Discussionsupporting

confidence: 90%

“…In addition, it is important to note that both study groups exceeded expectations for both CPR and LBR compared with our center's overall success rate in women <35 years old undergoing fresh autologous ET. This finding correlates with multiple research studies that showed that dual trigger improves IVF outcomes (38)(39)(40)(41)(42)(43). Included in these studies was TABLE 2 Clinical characteristics of cycles that did and did not achieve a live birth.…”

Section: Discussionsupporting

confidence: 73%

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Dual trigger protocol is an effective in vitro fertilization strategy in both normal and high responders without compromising pregnancy outcomes in fresh cycles

et al. 2021

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Objective: To study the birth rates of normal vs. high responders after dual trigger of final oocyte maturation with gonadotropinreleasing hormone (GnRH) agonist and human chorionic gonadotropin in fresh in vitro fertilization (IVF) cycles in which ovarian stimulation was achieved by a flexible GnRH antagonist protocol. Design: Retrospective cohort study. Setting: University hospital. Patient(s): In women <35 years of age, 290 fresh IVF cycles using the dual trigger protocol with day 5 embryo transfers from January 2013 to July 2018 were included. Cycles excluded were those with preimplantation genetic testing, gestational carriers, donor oocytes, and fertility preservation. Intervention(s): IVF with dual trigger. Main Outcome Measure(s): Clinical pregnancy rate, live birth rate. Result(s): Comparing normal responders, defined as <30 oocytes retrieved, and high responders, defined as R30 oocytes retrieved, the clinical pregnancy rates (67.0% vs. 69.3%, respectively) and live birth rates (60.5% vs. 60.0%, respectively) were not significantly different. No cases of ovarian hyperstimulation syndrome were reported in either group. Conclusion(s):Ovarian stimulation by a flexible GnRH antagonist protocol followed by dual trigger yields comparable outcomes between normal and high responders in fresh IVF cycles.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 73%

Dual trigger protocol is an effective in vitro fertilization strategy in both normal and high responders without compromising pregnancy outcomes in fresh cycles

et al. 2021

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Dual Trigger with hCG Plus GnRHa for Final Oocyte Maturation in PGT-A Cycles Results in Similar Euploidy Rates when Compared to hCG-Only Trigger

et al. 2022

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Reproductive outcomes of dual trigger with combination GnRH agonist and hCG versus trigger with hCG alone in women undergoing IVF/ICSI cycles: a retrospective cohort study with propensity score matching

Dong

Lian

et al. 2022

BMC Pregnancy Childbirth

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Background Despite a large number of studies on the selection of trigger drugs, it remains unclear whether the dual trigger with human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone (GnRH) agonist, compared to the trigger with hCG alone, can improve the reproductive outcome of patients undergoing assisted reproductive technology. Therefore, this study aimed to compare the laboratory and clinical outcomes of dual trigger versus single trigger. Methods In this retrospective cohort study, we evaluated 520 in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles between July 2014 and September 2020 at the Reproductive and Genetic Center of Integrative Medicine, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine. All patients underwent IVF/ICSI treatment with fresh embryo transfer using the GnRH antagonist protocol. We used propensity score matching to control for confounding variables and binary logistic regression analysis to determine the correlations between trigger methods and pregnancy outcomes. After propensity score matching, 57 cycles from each group were evaluated and compared for laboratory or clinical outcomes in this retrospective cohort study. Results There was no significant difference in the number of oocytes retrieved, embryos available, top-quality embryos, or the rate of normal fertilization between the dual-trigger and single-trigger protocols, respectively. The incidence of ovarian hyperstimulation syndrome, implantation rate, biochemical pregnancy rate, clinical pregnancy rate, ectopic pregnancy rate, early miscarriage rate, and live birth rate were also similar between the two groups, while the miscarriage rate (37.0% vs. 12.5%, p = 0.045) was higher in the dual-trigger than the single-trigger group. Subsequent binary logistic regression analysis showed that age was a remarkably significant independent predictor of both clinical pregnancy rate (odds ratio = 0.90, 95% confidence interval: 0.84–0.97, p = 0.006) and live birth rate (odds ratio = 0.89, 95% confidence interval: 0.82–0.97, p = 0.005). Conclusions Therefore, dual-trigger for final oocyte maturation might increase miscarriage rate, but in terms of the laboratory and other pregnancy outcomes such as clinical pregnancy rate, early miscarriage rate or live birth rate, there was no evidence to show that dual trigger was superior to an hCG-trigger alone for patients undergoing GnRH-antagonist cycles with fresh embryo transfer. Trial registration Retrospectively registered.

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Intérêt du double déclenchement par agoniste de la GnRH et hCG en cas d’antécédent d’immaturité ovocytaire en FIV/ICSI

Cited by 4 publications

References 20 publications

Dual trigger protocol is an effective in vitro fertilization strategy in both normal and high responders without compromising pregnancy outcomes in fresh cycles

Dual trigger protocol is an effective in vitro fertilization strategy in both normal and high responders without compromising pregnancy outcomes in fresh cycles

Dual Trigger with hCG Plus GnRHa for Final Oocyte Maturation in PGT-A Cycles Results in Similar Euploidy Rates when Compared to hCG-Only Trigger

Reproductive outcomes of dual trigger with combination GnRH agonist and hCG versus trigger with hCG alone in women undergoing IVF/ICSI cycles: a retrospective cohort study with propensity score matching

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