Intérêt des thérapies intravésicales en neuro-urologie

Abstract

Intravesical instillation therapy is an easy way to provide high concentrations of pharmacological agents to bladder tissue without causing significant systemic side effects. Urethral catheterization is frequently used for bladder management and follow-up in neurological patients, making such treatment easy to administer in this population. Several agents have been suggested, acting on either the afferent or efferent arm of the micturition reflex, for the treatment of hyperactive or underactive detrusor in patients who do not respond to first-line oral therapies. Despite the established interest of some agents, their use is limited by the lack of commercially available solutions and/or the short duration of the therapeutic effect, resulting in under-use of this promising approach.