Intérêt des marqueurs urinaires dans le diagnostic et le suivi des tumeurs urothéliales de vessie

Campos-Fernandes, Jean-Louis; Descôtes, Françoise; André, Jean; Perrin, Paul B.; Devonec, M.; Ruffion, A.

doi:10.1016/s1166-7087(07)92221-6

Cited by 6 publications

(1 citation statement)

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“…However, urine biomarkers have not been compared between them, so no conclusion can be drawn about which marker is the best one. The results of the assays we have summarized above of telomerase as urine biomarker of bladder cancer recommend its use in combination with other urinary biomarkers as FISH or cytology in high risk patients [61, 62]. We have not got yet enough evidence to eliminate cystoscopies from the diagnosis and surveillance of these patients.…”

Section: Telomerase As Cancer Marker: Urine Biomarkermentioning

confidence: 99%

Urine Telomerase for Diagnosis and Surveillance of Bladder Cancer

Lamarca

Barriuso²

2012

Advances in Urology

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Bladder cancer has increased incidence during last decades. For those patients with nonmuscle involved tumors, noninvasive diagnosis test and surveillance methods must be designed to avoid current cystoscopies that nowadays are done regularly in a lot of patients. Novel urine biomarkers have been developed during last years. Telomerase is important in cancer biology, improving the division capacity of cancer cells. Even urinary telomerase could be a potentially useful urinary tumor marker; its use for diagnosis of asymptomatic and symptomatic patients or its impact during surveillance is still unknown. Moreover, there will need to be uniformity and standardization in the assays before it can become useful in clinical practice. It does not seem to exist a real difference between the most classical assays for the detection of urine telomerase (TRAP and hTERT). However, the new detection methods with modified TeloTAGGG telomerase or with gold nanoparticles must also be taken into consideration for the correct development of this diagnosis method. Maybe the target population would be the high-risk groups within screening programs. To date there is no enough evidence to use it alone and to eliminate cystoscopies from the diagnosis and surveillance of these patients. The combination with cytology or FISH is still preferred.

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Section: Telomerase As Cancer Marker: Urine Biomarkermentioning

confidence: 99%