Interesting effect of Malassezia spp. infection on dermatoses of other origins

Abstract

Recent research has elucidated the immunomodulatory properties of Malassezia spp. in vitro. Our cases serve as possible in vivo models illustrating such properties. Further studies based on these reports could lead to the isolation of molecules from Malassezia, which may have potential use in anti-inflammatory drug formulations.

Sparing phenomena in dermatology

“…[2] This differs from the reverse isotopic phenomenon in that both the diseases are present simultaneously and one is not healed at the presentation of the other.…”

Pityriasis rosea sparing patches of tinea versicolor as anatopic response

“…Sir, Anatopic phenomenon denotes modification of the inflammatory response of one dermatosis by an unrelated skin infection at the same site. 1 Here we report a case of anatopic response, where the lesions of pityriasis rosea (PR) selectively spared the patches of pre-existing tinea versicolor in a patient.…”

“…Pakran et al reported four cases in which various dermatoses (viral exanthem, acute generalized exanthematous pustulosis, polymorphous light eruption, and irritant contact dermatitis) spared the sites affected with tinea versicolor. 1 They postulated that Malassezia might be eliciting local immunomodulation or may be acting as a physical barrier. Shenoy et al reported a case of dithranolinduced erythema sparing tinea versicolor lesions.…”