Interest of the plasma neutrophil gelatinase associated lipocalin in adult ICU patients starting oliguria

Abstract

Materials and Methods:We prospectively studied 110 adult patients who were randomly assigned to two groups. Group I was treated with 2 L of SS (300 mEq Na)+ 0.5 L 30% dex trose (150 gr) and Group II with 2.5 L 0,3 Dextro-Saline (125 mEq Na and 150 gr dex trose), during the first 24 hours af ter surgery. All patients were monitored with volumetric parameters and if hypovolemic (SV V >10%) they received a fluid bolus (250 mL SS or HES). Patients with renal failure and pneumonectomy were excluded. Blood samples were taken af ter 24 hours of treatment and electroly tes determined. We also registered total fluid infused (TFI), urine output and weight changes. Student's T test was used for intergroups comparison. Results in mean±SD. Results and Discussion: No dif ferences were found between groups in terms of sex distribution (males 66%), age (median 66), history of hypertension (48%) or diabetes (28%). Patients underwent abdominal (36), vascular (28), thoracic (28) and urologic (18) procedures. No dif ferences were found between groups in electroly te levels and acid-base balance at 24 hours, neither in TFI, urine output or weight changes (Table I). No hyperclorhremic acidosis neither hyponatremia were seen in any patient. Group I (n=55)Group II (n=55) ph 7.35±0.04Background and Goal of Study: Contrast induced nephropathy (CIN) is an important cause of hospital-acquired acute renal failure and increases mortal-