Interest of punch skin grafting for the treatment of painful ulcers

Fourgeaud, C.; Mouloise, G.; Michon-Pasturel, U.; Bonhomme, S.; Lazareth, I.; Meaume, Sylvie; Priollet, P.

doi:10.1016/j.jmv.2016.08.002

Cited by 14 publications

(9 citation statements)

References 3 publications

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“…Although some pinch or punch grafts may not adhere to the wound bed, they release growth factors, signal molecules and cells that enhance epithelial resurfacing and reduce pain. [268][269][270] Other options include the previously-covered photobiomodulation device LumiHeal (Klox) and proteasemodulating technologies.…”

Section: Advanced and Other Therapy Options For Reducing Wound Sizementioning

confidence: 99%

Implementing TIMERS: the race against hard-to-heal wounds

et al. 2019

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Section: Advanced and Other Therapy Options For Reducing Wound Sizementioning

confidence: 99%

Implementing TIMERS: the race against hard-to-heal wounds

et al. 2019

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“…10 Les greffes en pastilles présentent un effet antalgique rapide (dans les heures qui suivent la procédure de greffe) et prolongé, associé à une régression du halo érythématoviolacé entre 3 et 17 jours après la greffe. 5, 11 . Cette diminution, voire suppression, de la douleur est indépendante du pourcentage de prise de greffe 12 et probablement en rapport avec les facteurs de croissance libérés par les greffons en pastilles.…”

Section: Quelle Greffe Pour Quel Ulcère ?unclassified

Prise en charge des ulcères chroniques : la greffe en pastilles

Koulouri¹,

Buset²,

Hafner³

et al. 2022

Revue Médicale Suisse

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Les ulcères chroniques représentent un problème dermatologique courant et donc une source majeure de dépenses dans les pays occidentaux. La greffe de peau est une intervention chirurgicale au cours de laquelle la peau ou un substitut de peau est transplanté afin de favoriser la cicatrisation d'une plaie. Cet article a pour but de faire le point sur les différentes catégories de greffe, leurs indications dans la prise en charge des ulcères chroniques des membres inférieurs en soulignant la place des greffes en pastilles dans l'arsenal thérapeutique à disposition.

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“…In our clinical practice, we have confirmed that even if the wound bed does not present with perfect conditions for grafting, punch grafts that do not successfully adhere release growth factors and cells that promote wound epithelialization and reduce pain. Punch grafting in painful ulcers may produce a striking early analgesic effect [8][9][10] and is therefore a technique that is very well accepted by patients.…”

Section: Acknowledgmentsmentioning

confidence: 99%

“…The most-used type of thin split-thickness skin graft is the mesh graft obtained with dermatome; this technique requires sophisticated material and must be performed in the operating room with the patient under general or loco-regional anesthesia [7]. Punch grafting is another type of thin split-thickness skin graft, less aggressive and more simple than the mesh graft, which does not require the use of complex instruments [8][9][10] and can even be performed on an outpatient basis. Being carried out on an outpatient basis is interesting from an economic point of view, as it minimizes costs compared to hospital level implementation [11].…”

Section: Introductionmentioning

confidence: 99%

Bayesian Regression Model for a Cost-Utility and Cost-Effectiveness Analysis Comparing Punch Grafting Versus Usual Care for the Treatment of Chronic Wounds

Sevilla

Conde-Montero

Gerónimo-Pardo

2020

IJERPH

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Punch grafting is a traditional technique used to promote epithelialization of hard-to-heal wounds. The main purpose of this observational study was to conduct a cost-utility analysis (CUA) and a cost-effectiveness analysis (CEA) comparing punch grafting (n = 46) with usual care (n = 34) for the treatment of chronic wounds in an outpatient specialized wound clinic from a public healthcare system perspective (Spanish National Health system) with a three-month time horizon. CUA outcome was quality-adjusted life years (QALYs) calculated from EuroQoL-5D, whereas CEA outcome was wound-free period. One-way sensitivity analyses, extreme scenario analysis, and re-analysis by subgroups were conducted to fight against uncertainty. Bayesian regression models were built to explore whether differences between groups in costs, wound-free period, and QALYs could be explained by other variables different to treatment. As main results, punch grafting was associated with a reduction of 37% in costs compared to usual care, whereas mean incremental utility (0.02 ± 0.03 QALYs) and mean incremental effectiveness (7.18 ± 5.30 days free of wound) were favorable to punch grafting. All sensitivity analyses proved the robustness of our models. To conclude, punch grafting is the dominant alternative over usual care because it is cheaper and its utility and effectiveness are greater.

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Interest of punch skin grafting for the treatment of painful ulcers

Cited by 14 publications

References 3 publications

Implementing TIMERS: the race against hard-to-heal wounds

Implementing TIMERS: the race against hard-to-heal wounds

Prise en charge des ulcères chroniques : la greffe en pastilles

Bayesian Regression Model for a Cost-Utility and Cost-Effectiveness Analysis Comparing Punch Grafting Versus Usual Care for the Treatment of Chronic Wounds

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