Interest of HYPR flow dynamic MRA for characterization of cerebral arteriovenous malformations: comparison with TRICKS MRA and catheter DSA

Dautry, Raphaël; Edjlali, Myriam; Roca, Pauline; Rabrait, C.; Wu, Yijing; Johnson, Kevin M.; Wieben, O; Trystram, Denis; Rodriguez-Régent, Christine; Alshareef, Fawaz; Turski, Patrick A.; Méder, Jean-François; Naggara, Olivier; Oppenheim, Catherine

doi:10.1007/s00330-015-3745-9

Cited by 12 publications

(19 citation statements)

References 28 publications

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“…Therefore, MR angiography (MRA) is a natural application for sparse reconstructions. Both contrast enhanced 99 and non-contrast enhanced MRA 100 have been examined in a variety of applications, including intracranial vasculature 101,102 , carotids 103,104 , coronaries 19 , and pulmonary veins 105 . Reducing the acquisition time enables the dynamic visualization of the flow of blood sequentially into arteries and then veins via repeated rapid imaging.…”

Section: Clinical Applications Of Sparse Reconstruction Techniquesmentioning

confidence: 99%

Sparse Reconstruction Techniques in Magnetic Resonance Imaging

Yang

Kretzler

Sudarski

et al. 2016

Investigative Radiology

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The family of sparse reconstruction techniques, including the recently introduced compressed sensing framework, has been extensively explored to reduce scan times in Magnetic Resonance Imaging (MRI). While there are many different methods that fall under the general umbrella of sparse reconstructions, they all rely on the idea that a priori information about the sparsity of MR images can be employed to reconstruct full images from undersampled data. This review describes the basic ideas behind sparse reconstruction techniques, how they could be applied to improve MR imaging, and the open challenges to their general adoption in a clinical setting. The fundamental principles underlying different classes of sparse reconstructions techniques are examined, and the requirements that each make on the undersampled data outlined. Applications that could potentially benefit from the accelerations that sparse reconstructions could provide are described, and clinical studies using sparse reconstructions reviewed. Lastly, technical and clinical challenges to widespread implementation of sparse reconstruction techniques, including optimization, reconstruction times, artifact appearance, and comparison with current gold-standards, are discussed.

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Section: Clinical Applications Of Sparse Reconstruction Techniquesmentioning

confidence: 99%

Sparse Reconstruction Techniques in Magnetic Resonance Imaging

Yang

Kretzler

Sudarski

et al. 2016

Investigative Radiology

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“…This technique has been used with success to characterize AVMs, which similarly to DAVFs requires high spatial and temporal resolution due to their rapid arteriovenous shunting and small feeding vessels. (18, 19) HYPRFlow is well suited for characterizing AVMs and DAVFs because whole brain coverage allows the whole lesion to be characterized which is possible because the relative sparsity of vessels in 3D space allows for the use of undersampling techniques such as radial acquisition (VIPR). Previous work has demonstrated that use of the HYPR reconstruction method provides improved SNR compared to radially sampling k -space with a sliding window reconstruction method (33)…”

Section: Discussionmentioning

confidence: 99%

“…Previous reports have demonstrated the value of using radial undersampling and highly constrained reconstruction (HYPRFLow) to characterizing brain AVMs. (17-19)…”

Section: Introductionmentioning

confidence: 99%

Accelerated Time-Resolved Contrast-Enhanced Magnetic Resonance Angiography of Dural Arteriovenous Fistulas Using Highly Constrained Reconstruction of Sparse Cerebrovascular Data Sets

Clark

Johnson

Wu³

et al. 2016

Investigative Radiology

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Objective Time resolved contrast enhanced magnetic resonance angiography (TR CEMRA) is commonly used to non-invasively characterize vascular malformations. However, the spatial and temporal resolution of current methods often compromises the clinical value of the exams. Constrained reconstruction is a temporal spatial correlation strategy that exploits the relative sparsity of vessels in space to dramatically reduce the amount of data required to generate fast high resolution TR CEMRA studies. In this report we use a novel temporal spatial acceleration method termed HYPRFLow to diagnose and classify dural arteriovenous fistulas (DAVFs). Our hypothesis is that HYPRFLow images are of adequate diagnostic image quality to delineate the arterial and venous components of DAVFs and allow correct classification using the Cognard system. Subjects and Methods 8 patients with known DAVFs underwent HYPRFlow imaging with isotropic resolution of 0.68 mm and temporal resolution of 0.75 s and 3D Time of Flight MRA (3DTOF). 3DTOF images and HYPRFLow images were evaluated by 2 readers and scored for arterial anatomic image quality. DSA was available for comparison in seven subjects and for these patients each DAVF was classified according to the Cognard system using HYPRFlow and DSA exams. DSA was considered the reference exam or gold standard. Results HYPRFlow imaging classification was concordant with DSA in all but one case. There was no difference in the arterial image quality scores between HYPRFlow and 3DTOF MRA (95% CI). Arterial to venous separation was rated excellent (n=3), good (n=4) or poor (n=1)and arteriovenous shunting was easily appreciated. Undersampling artifacts were reduced by using a low pass filter and did not interfere with the diagnostic quality of the exams. Conclusion HYPRFlow is a novel acquisition and reconstruction technique that exploits the relative sparsity of intracranial vessels in space to increase temporal and spatial resolution and provides accurate delineation of DAVF vasculature.

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“…However, these results are a first report of VB and are based on a small collective. HFMRA has been shown to be well suited to study AVMs and the addition of TOA and VB further improves the performance of the technique (11, 13). This is underlined by the theoretical consideration that HYPRFlow produces images which depict subtle changes in signal intensity; however, temporal signal variations are only one factor that influences brightness and thus it may be challenging to interpret the images.…”

Section: Discussionmentioning

confidence: 99%

“…The arterial delineation is comparable to widely used non dynamic time-of–flight MRA (10). Moreover, it has been shown to perform well in the evaluation of the complex vessel networks of intracranial AVMs and arteriovenous fistulas (11-13). In contrast to intra-arterial digital subtraction angiography (DSA), all time resolved imaging techniques using venous injection of contrast agent suffer from significant dispersion of the contrast bolus resulting from the circulation through the heart and lungs.…”

Section: Introductionmentioning

confidence: 99%

Time-of-Arrival Parametric Maps and Virtual Bolus Images Derived From Contrast-Enhanced Time-Resolved Radial Magnetic Resonance Angiography Improve the Display of Brain Arteriovenous Malformation Vascular Anatomy

Schubert

Johnson

et al. 2016

Invest Radiol

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Objectives Time-of-arrival (TOA) maps can be derived from high-resolution 4D contrast-enhanced magnetic-resonance-angiography (MRA) datasets to provide a quantitative description of contrast material arrival time in each voxel. This information can further be processed in order to create a compressed time-evolution curve that virtually shortens the contrast bolus (Virtual Bolus [VB]). The purpose of this project is to determine whether TOA-enhanced 4D MRA and/or Virtual Bolus Imaging improve the display of contrast kinetics in patients with vascular disease. Methods High-resolution whole brain contrast enhanced 4D MRA exams with 1.2 second temporal reconstruction were acquired by using radial acquisition and highly constrained projection reconstruction (radial 4D CE HYPRFlow, is abbreviated to HFMRA in this manuscript) in 10 patients (8 patients with vascular malformations (AVM), one patient with an arteriovenous fistula (AVF) and one patient with a high-grade intracranial stenosis). The TOA for each voxel was defined as the time point when the signal intensity reached 20% of its maximum. In the first method, TOA maps were generated, color-encoded and then multiplied with the time-resolved contrast enhanced MRA images at each time frame to form new 4D MRA images (TOA-enhanced HFMRA) which contains the contrast arrival times with defined color encoding. In the second method, each time frame was weighted by a Gaussian distribution in the time domain to form a virtual 4D bolus map. This 4D bolus map was then color-coded and multiplied with the HFMRA images to form a digital subtraction angiography (DSA)-like virtual bolus, where at each time frame, only vessels with certain TOA values within the defined bolus length appear. HFMRA, TOA maps and virtual bolus images were scored qualitatively with regard to delineation of arteries, veins and nidus as well as artifacts. Furthermore, diagnostic confidence and arteriovenous overlap were evaluated and compared between techniques. A comparison with DSA was performed where DSA served as the reference standard in terms of number of arterial feeders, draining veins and Spetzler-Martin score of AVMs. In addition, TOA-maps were evaluated quantitatively. Results Overall diagnostic confidence score of TOA was significantly higher compared to HFMRA (p=0.03). Virtual Bolus (VB) showed significantly higher scores for overall diagnostic confidence (p=0.02) and reduced arteriovenous overlap (0.01) compared to HFMRA. Furthermore, Virtual Bolus reduced arteriovenous overlap significantly compared to TOA (p=0.04). Agreement regarding AVM draining veins was lower between DSA and HFMRA (k=0.3) compared to TOA and VB (k=0.56). Agreement regarding Spetzler-Martin score was lower between DSA and HFMRA (k=0.56) compared to TOA and VB (k=0.74). Conclusion TOA-enhanced HFMRA provides serial images and time of arrival maps in one inclusive display. In this study, TOA mapping combined with Virtual Bolus imaging improved diagnostic confidence in AVM patients and facilitated arteriovenous sep...

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Interest of HYPR flow dynamic MRA for characterization of cerebral arteriovenous malformations: comparison with TRICKS MRA and catheter DSA

Cited by 12 publications

References 28 publications

Sparse Reconstruction Techniques in Magnetic Resonance Imaging

Sparse Reconstruction Techniques in Magnetic Resonance Imaging

Accelerated Time-Resolved Contrast-Enhanced Magnetic Resonance Angiography of Dural Arteriovenous Fistulas Using Highly Constrained Reconstruction of Sparse Cerebrovascular Data Sets

Time-of-Arrival Parametric Maps and Virtual Bolus Images Derived From Contrast-Enhanced Time-Resolved Radial Magnetic Resonance Angiography Improve the Display of Brain Arteriovenous Malformation Vascular Anatomy

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