Interdisciplinary palliative care, including massage, in treatment of amyotrophic lateral sclerosis

Blatzheim, Kendra

doi:10.1016/j.jbmt.2008.04.040

Cited by 14 publications

(9 citation statements)

References 46 publications

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“…Previous studies have reported a prevalence of depression of 4–56% depending on the assessment measure. [ 24 95 113 242 287 322 ] Depression has a negative effect on the quality of life of patients with ALS. [ 52 156 173 ] In a recent study, 131 patients with ALS were evaluated to estimate the prevalence of depression.…”

Section: Analysis Of Co-morbidities Of Amyotrophic Lateral Sclerosismentioning

confidence: 99%

A comprehensive review of amyotrophic lateral sclerosis

et al. 2015

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Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting motor neurons with an incidence of about 1/100,000. Most ALS cases are sporadic, but 5–10% of the cases are familial ALS. Both sporadic and familial ALS (FALS) are associated with degeneration of cortical and spinal motor neurons. The etiology of ALS remains unknown. However, mutations of superoxide dismutase 1 have been known as the most common cause of FALS. In this study, we provide a comprehensive review of ALS. We cover all aspects of the disease including epidemiology, comorbidities, environmental risk factor, molecular mechanism, genetic factors, symptoms, diagnostic, treatment, and even the available supplement and management of ALS. This will provide the reader with an advantage of receiving a broad range of information about the disease.

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Section: Analysis Of Co-morbidities Of Amyotrophic Lateral Sclerosismentioning

confidence: 99%

A comprehensive review of amyotrophic lateral sclerosis

et al. 2015

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“…Instead, it potentiated mitochondrial biogenesis signaling, attenuated the production of inflammatory cytokines IL‐6 and TNF‐alpha, and reduced heat shock protein 27 phosphorylation, mitigating cellular stress resulting from myofiber injury. Massage therapy has been recommended as an adjunctive treatment for spasticity and pain in ALS . It has successfully treated neuropathic pain after spinal injury and chemotherapy‐induced peripheral neuropathy, so it could be of potential benefit in CMT.…”

Section: New Approaches To Exercise Training In Nmdmentioning

confidence: 99%

“…Massage therapy has been recommended as an adjunctive treatment for spasticity and pain in ALS. 189,190 It has successfully treated neuropathic pain after spinal injury 191 and chemotherapyinduced peripheral neuropathy, 192 so it could be of potential benefit in CMT.…”

Section: New Approaches To Exercise Training In Nmdmentioning

confidence: 99%

Exercise in neuromuscular disease

Anziska

Sternberg

2013

Muscle and Nerve

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In this review, we present an overview of the role of exercise in neuromuscular disease (NMD). We demonstrate that despite the different pathologies in NMDs, exercise is beneficial, whether aerobic/endurance or strength/resistive training, and we explore whether this benefit has a similar mechanism to that of healthy subjects. We discuss further areas for study, incorporating imaginative and novel approaches to training and its assessment in NMD. We conclude by suggesting ways to improve future trials by avoiding previous methodological flaws and drawbacks in this field.

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“…Furthermore, spasticity can have musculoskeletal consequences due to involuntary mobilization of stiff joints, muscle contractures, pressure pain, such as shoe agitation due to striatal toe of Babinski sign or even decubitus ulcers due to immobility and skin breakdown in flexor creases [25–28]. All of these muscle hyperactivity-induced changes can distort muscle mechanics to a degree that substantially alter posture, range of motion, ambulation, and gait, thus creating new sources of pain [29]. …”

Section: Pain In Alsmentioning

confidence: 99%

Pain in Amyotrophic Lateral Sclerosis: A Neglected Aspect of Disease

Handy

Krudy

Boulis

et al. 2011

Neurology Research International

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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder marked by progressive loss of motor neurons, muscle wasting, and respiratory dysfunction. With disease progression, secondary symptoms arise creating new problematic conditions for ALS patients. Amongst these is pain. Although not a primary consequence of disease, pain occurs in a substantial number of individuals. Yet, studies investigating its pathomechanistic properties in the ALS patient are lacking. Therefore, more exploratory efforts into its scope, severity, impact, and treatment should be initiated. Several studies investigating the use of Clostridial neurotoxins for the reduction of pain in ALS patients suggest the potential for a neural specific approach involving focal drug delivery. Gene therapy represents a way to accomplish this. Therefore, the use of viral vectors to express transgenes that modulate the nociceptive cascade could prove to be an effective way to achieve meaningful benefit in conditions of pain in ALS.

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Interdisciplinary palliative care, including massage, in treatment of amyotrophic lateral sclerosis

Cited by 14 publications

References 46 publications

A comprehensive review of amyotrophic lateral sclerosis

A comprehensive review of amyotrophic lateral sclerosis

Exercise in neuromuscular disease

Pain in Amyotrophic Lateral Sclerosis: A Neglected Aspect of Disease

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