Interdigitated microelectronic bandage augments hemostasis and clot formation at low applied voltage<i>in vitro</i>and<i>in vivo</i>

Hardy, Elaissa T.; Wang, Yannan J.; Iyer, Sanathan; Mannino, Robert G.; Sakurai, Yumiko; Barker, Thomas H.; Chi, Taiyun; Youn, Yeojoon; Wang, Hua; Brown, Ashley; Lam, Wilbur A.

doi:10.1039/c8lc00573g

Cited by 8 publications

(7 citation statements)

References 22 publications

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“…Without the application of voltage, the bandage took approximately 180 s to achieve hemostasis. 61 In vitro hemolysis testing, the macroscopical color of the supernatants from the four sample groups was displayed in Figure 7F, (hydrogel film, commercial gauze, the positive control group (water), and the negative control group (normal saline)). The supernatants of hydrogel film and commercial gauze groups were slightly yellow like saline, but different from the water sample (bright red) color as shown in Figure 7G.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

A Transparent, Tough and Self-Healable Biopolymeric Composites Hydrogel for Open Wound Management

Kuddushi,

Deng,

Nayak

et al. 2023

ACS Appl. Bio Mater.

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Modern healthcare engineering requires a wound dressing solution supported by materials with outstanding features such as high biological compatibility, strong mechanical strength, and higher transparency with effective antibacterial properties. Here, we present a unique hydrogel technology consisting of two negatively charged biopolymers and a positively charged synthetic polymer. The interaction between charged polymers through hydrogen bonds has been created, which are revealed in the simulation by density functional theory and Fourier transform infrared spectra of individual polymers and the hydrogel film. The transparent hydrogel film dressings showed excellent stretchability, a higher water swelling ratio (60%), and strong mechanical strength (∼100 MPa) with self-healing abilities (85−90%). The fabricated hydrogel film showed stable blood clots (within 119 ± 15 s) with rapid hemostasis (<2%) properties and effective antibacterial studies against E. coli and S. aureus bacterial strains. In addition, the obtained hydrogel film also showed excellent cell viability on mouse fibroblast cells. With their enormous amenability to modification, these hydrogel films may serve as promising biomaterials for wound dressing applications.

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Section: ■ Results and Discussionmentioning

confidence: 99%

A Transparent, Tough and Self-Healable Biopolymeric Composites Hydrogel for Open Wound Management

Kuddushi,

Deng,

Nayak

et al. 2023

ACS Appl. Bio Mater.

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“…Cotton fibres must be sterilized to avoid bacterial growth before using it for making bandages [42]. Hardy [43] et al reported a bandage for enhancing the blood clotting rate using a mesh comprising of alternate gold strings for supplying voltage to the wound site (Fig. 1).…”

Section: Worldwide Progress In Bandage Designmentioning

confidence: 99%

Design and simulation of microfluidic smart bandage using Comsol Multiphysics

Rajput¹

2021

TURCOMAT

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Microfluidics is an emerging field finding its applications in biomedical engineering for investigations of cellular micro structures. Human body is composed of 70% of water having thin and fine structure of microfluidic blood channels spread throughout the body. These microchannels supply essential nutrients to each part of the body at right time and in right amount. Microfluidics is the science of controlling and manipulating the fluid in micro channels. Manipulating the flow through the microchannels is useful for developing electronic devices, artificial human body parts, and economical diagnostics tools. Microfluidics also helps in manufacturing of pharmaceuticals and carrying out precise chemical analysis of complex systems. A number of diagnostic devices and artificial human organs like lungs, heart, kidneys, etc. have been simulated using microfluidics for developing easy, economical, non-invasive, and rapid method of drug testing. Recently, its applications have also been investigated in smart bandage design. Further, blend of microfluidics with herbal medicines is expected to enhance the healing along with negligible side effects unlike allopathic treatments. The scope of the present research is to develop a smart bandage capable of sensing the status of the wound and supplying required amount of drugs using microfluidic channels. The flow rate of drugs through microchannels is simulated using the physics of laminar flow, capillary action, and diffusion phenomena for optimizing the size and shape of the constituent components of the bandage like microfluidic channels, mixers, and porous material used for drug distribution with in the active area of the bandage. The analysis of the results shows that the mixer having inner radius as 150 microns and outer radius as 250 microns is sufficient to mix the incoming drugs via inlets of 50 microns’ diameter. Results also show that capillary action dominates the diffusion phenomenon for supplying the drugs to the wound. The investigations of the prototype show that a smart bandage having the provisions of uniform drug distribution, automatic control, on board pH, moisture, O2 measurement, and dc current based healing mechanism is possible to be incorporated with in a comfortable size for fast wound healing.

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“…Unlike the PA design that utilizes an impedance transformation network to realize the desired RL, here, RL is the effective parallel resistance of the inductor. Therefore, once RL is determined, the optimal LD can be calculated based on (8), and the required Cex to sustain the oscillation at the desired frequency can be calculated based on (9). Next, gate capacitances C1-CN are chosen to make sure all transistors are within the breakdown limit.…”

Section: A Stacked Oscillatormentioning

confidence: 99%

An Integrated Microheater Array With Closed-Loop Temperature Regulation Based on Ferromagnetic Resonance of Magnetic Nanoparticles

Fan

Zhang

et al. 2021

IEEE Trans. Biomed. Circuits Syst.

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Magnetic nanoparticles (MNP) can generate localized heat in response to an external alternating magnetic field, a unique capability that has enabled a wide range of biomedical applications. Compared with other heating mechanisms such as dielectric heating and ohmic heating, MNP-based magnetic heating offers superior material specificity and minimal damage to the surrounding environment since most biological systems are non-magnetic. This paper presents a first-of-its-kind fully integrated magnetic microheater array based on the ferromagnetic resonance of MNP at Gigahertz (GHz) microwave frequencies. Each microheater pixel consists of a stacked oscillator to actuate MNP with a high magnetic field intensity and an electrothermal feedback loop for precise temperature regulation. The four-stacked/five-stacked oscillator achieves >19.5/26.5 Vpp measured RF output swing from 1.18 to 2.62 GHz while only occupying a single inductor footprint, which eliminates the need for additional RF power amplifiers for compact pixel size (0.6 mm × 0.7 mm) and high dc-to-RF energy efficiency (45%). The electrothermal feedback loop senses the local temperature and enables closed-loop temperature regulation by controlling the biasing voltage of the stacked oscillator, achieving a measured maximum/RMS temperature error of 0.53/0.29 °C. In the localized heating demonstration, two PDMS membranes mixed with and without MNP are attached to the microheater array chip, respectively, and their surface temperatures are monitored by an infrared (IR) camera. Only the area above the inductor (~0.03 mm 2 ) is efficiently heated up to 43 ºC for the MNP-PDMS membrane, while the baseline temperature stays <37.8 °C for the PDMS membrane without MNP.

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Interdigitated microelectronic bandage augments hemostasis and clot formation at low applied voltagein vitroandin vivo

Cited by 8 publications

References 22 publications

A Transparent, Tough and Self-Healable Biopolymeric Composites Hydrogel for Open Wound Management

A Transparent, Tough and Self-Healable Biopolymeric Composites Hydrogel for Open Wound Management

Design and simulation of microfluidic smart bandage using Comsol Multiphysics

An Integrated Microheater Array With Closed-Loop Temperature Regulation Based on Ferromagnetic Resonance of Magnetic Nanoparticles

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