Interdigestive gastroduodenal motility and serum motilin levels in patients with idiopathic delay in gastric emptying

Labò, G; Bortolotti, Mauro; Vezzadini, P; Bonora, G; Bersani, G.

doi:10.1016/0016-5085(86)90069-7

Cited by 103 publications

(44 citation statements)

References 13 publications

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“…Furthermore, duodenal acidification was found to induce gastric relaxation by an inhibitory effect on the stomach in animals (11). Through these pathways, increased duodenal acid exposure might contribute to the occurrence of delayed gastric emptying, antral hypomotility, or impaired interdigestive motility, all of which have been reported to occur in FD (3,9,12,24,29).…”

Section: Discussionmentioning

confidence: 97%

Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans

Lee

Vos

Janssens

et al. 2004

American Journal of Physiology-Gastrointestinal and Liver Physi

121

110

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Section: Discussionmentioning

confidence: 97%

Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans

Lee

Vos

Janssens

et al. 2004

American Journal of Physiology-Gastrointestinal and Liver Physi

121

110

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“…Furthermore, presence of acid in the duodenum has been shown to prevent the occurrence of gastric phase III (36), and suppression of acid secretion with proton pump inhibitors stimulates the occurrence of a gastric phase III (37). Through these pathways, increased duodenal acid exposure might contribute to the occurrence of delayed gastric emptying, antral hypomotility, or impaired interdigestive motility, all of which have been reported to occur in FD (1,2,7,(38)(39)(40). In addition, previous studies have shown that simultaneous or even preceding chemical stimulation is able to induce sensitization at the peripheral or the central level (41)(42)(43)(44).…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study on Duodenal Acid Exposure and Its Relationship to Symptoms in Functional Dyspepsia with Prominent Nausea

et al. 2004

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BACKGROUND: Duodenal hypersensitivity to acid and decreased duodenal clearance of exogenous acid have been reported in functional dyspepsia (FD). However, the relevance of these abnormalities to spontaneous duodenal acid exposure and dyspeptic symptoms in FD is unknown. AIMS:To determine spontaneous duodenal acid exposure and its relationship with symptoms, duodenal sensitivity to acid, and the effects of a 5-HT 3 receptor antagonist on duodenal responses to acid in FD. METHODS:Eleven FD patients with prominent nausea and 11 healthy controls underwent 24-h ambulatory duodenal pH monitoring with assessment of dyspeptic symptoms. On the next day, duodenal bolus infusions of 5 ml of acid and normal saline were given in a randomized double-blind manner and repeated after ondansetron or a placebo. RESULTS:Nighttime duodenal acid exposure was similar, but FD patients had lower duodenal pH and higher duodenal % time (pH < 4) than controls during the daytime and in the second postprandial 2 h (p < 0.05). Seven patients (64%) with duodenal acid exposure above the normal range had higher severity scores for several dyspeptic symptoms including nausea. However, the symptom severity was poorly or weakly correlated to duodenal pH, and brief duodenal acid infusion did not affect any symptoms. Duodenal responses to exogenous acid were unaffected by 5-HT 3 receptor antagonism.CONCLUSIONS: Spontaneous duodenal acid exposure is increased in a subset of FD patients with prominent nausea, and this is associated with more severe dyspeptic symptoms. However, a direct relationship between duodenal acid exposure and symptom severity is lacking.

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“…Moreover, the results of many previous studies in gastric motility abnormalities have identified a variety of abnormalities, including delayed gastric emptying, 4,17,18 adaptive relaxation disorder, 5 intragastric food distribution abnormalities, [19][20][21] postprandial antral dysmotility, 22 gastric electrical activity abnormalities, [23][24][25] decreased interdigestive migrating contractions, 26,27 and postprandial hypercontraction of the gastric fundus. 29 According to reports, adaptive relaxation disorders and delayed gastric emptying are particularly associated with upper gastrointestinal symptoms.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Gastric Motility Disorders in Patients with Functional Dyspepsia

Tomita¹,

Asano²,

Nakamura³

et al. 2017

Gastroenterology

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Interdigestive gastroduodenal motility and serum motilin levels in patients with idiopathic delay in gastric emptying

Cited by 103 publications

References 13 publications

Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans

Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans

A Pilot Study on Duodenal Acid Exposure and Its Relationship to Symptoms in Functional Dyspepsia with Prominent Nausea

Prevalence of Gastric Motility Disorders in Patients with Functional Dyspepsia

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