Intercurrent Factors Associated with the Development of Open-Angle Glaucoma in the European Glaucoma Prevention Study

Miglior, Stefano; Torri, Valter; Zeyen, Thierry; Pfeiffer, Norbert; Vaz, José Cunha; Adamsons, Ingrid

doi:10.1016/j.ajo.2007.04.040

Cited by 162 publications

(126 citation statements)

References 41 publications

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“…This may have reduced the significance of the baseline IOP as predictor, considering that IOP-related intercurrent factors, such as mean follow-up IOP and mean follow-up IOP reduction, have been demonstrated to be significant predictors for the glaucoma conversion in OHT patients. 31 The mean CCT value of our cohort of patients was lower than that reported by other studies for OHT subjects. 32,33 Considering that a substantial number of OHT patients tend to have an overestimation of GAT IOP based on a thicker cornea, 34 the significance of the CCT value as predictor for POAG development could be related to the proportion of false-positive OHT patients included in the study.…”

Section: Discussioncontrasting

confidence: 78%

Baseline factors predicting the risk of conversion from ocular hypertension to primary open-angle glaucoma during a 10-year follow-up

Salvetat

Zeppieri

Tosoni

et al. 2016

Eye

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Section: Discussioncontrasting

confidence: 78%

Baseline factors predicting the risk of conversion from ocular hypertension to primary open-angle glaucoma during a 10-year follow-up

Salvetat

Zeppieri

Tosoni

et al. 2016

Eye

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“…The type and duration of BP-lowering treatment may also contribute to glaucoma risk. In the European Glaucoma Prevention Study the use of diuretics was an independent risk factor for OAG incidence (OR, 2.41; 95% CI, 1.12-5.19) [37]. This suggests that the type of BP-lowering treatment may be an additional variable to consider when assessing PP.…”

Section: Pp: a Tricky Variable With Regards To Iop And Bpmentioning

confidence: 99%

Weighing in Ocular Perfusion Pressure in Managing Glaucoma

Topouzis

Founti²

2009

TOOPHTJ

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The role of vascular risk factors in glaucoma is increasingly being supported by the literature, with the association between low ocular perfusion pressure (PP) and glaucoma being the most consistent result. However, we need to be cautious when interpreting these results and consider all possible confounders in the observed associations. While we assess PP through its principal components, the weight of intraocular pressure (IOP) and blood pressure (BP) in the PP equation remains unknown. Also, the role of PP in glaucoma needs to be elucidated with regards to IOP and BP fluctuation during the 24hour period and the effect of IOP-lowering and BP-lowering treatment. The complexity of the interaction of PP with other potential risk factors for glaucoma means that PP cannot be currently considered in the assessment of an individual patient. The role of PP in glaucoma warrants further research and randomized clinical trials assessing PP should include vision and/or structure preservation as end-points and ideally address all of the above issues.

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“…Conversely, the Barbados Eye Studies found more than a twofold increase in risk (relative risk 2.4, 95% CI 1.3 to 4.6) after adjustment for age, gender, IOP, and IOP and blood pressure treatment. 38 Other ocular conditions, such as PEX 36,37,41,92 and optic disc haemorrhage, 78,91,93 have been found to be predictive for the development of OAG. The OHTS excluded individuals with PEX and pigment dispersion whereas the EGPS included only 19 individuals with these conditions and they were excluded from the pooled analyses.…”

Section: Systematic Reviewmentioning

confidence: 99%

“…64 Nevertheless, unpublished data from the EGPS showed that conversion to OAG was almost the same in the group of patients with both eyes included as in those with only one eye included in the trial. 91 When both eyes are available, an alternative approach is to use the 'worse' eye, the eye at higher risk of developing OAG; however, this can be problematic when a single variable cannot be used to identify the 'worse' eye. Identification of the worse eye in the OHTS-EGPS 'worse' eye model was based on IOP, CCT, VCD ratio and PSD.…”

Section: Systematic Reviewmentioning

confidence: 99%

Surveillance for ocular hypertension: an evidence synthesis and economic evaluation

2012

Clinical Governance: An International Journal

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Intercurrent Factors Associated with the Development of Open-Angle Glaucoma in the European Glaucoma Prevention Study

Cited by 162 publications

References 41 publications

Baseline factors predicting the risk of conversion from ocular hypertension to primary open-angle glaucoma during a 10-year follow-up

Baseline factors predicting the risk of conversion from ocular hypertension to primary open-angle glaucoma during a 10-year follow-up

Weighing in Ocular Perfusion Pressure in Managing Glaucoma

Surveillance for ocular hypertension: an evidence synthesis and economic evaluation

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