Intercultivar difference with respect to mutagenicity of fava beans (Vicia faba L.) after incubation with nitrite

Hoeven, J.C.M. van der; Lagerweij, W.J.; Gastel, A. Van; Huitink, J.; Dreu, Rok; Broekhoven, L.W. van

doi:10.1016/0165-1161(84)90010-4

Cited by 4 publications

(1 citation statement)

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“…Several reports show the appearance of a clear mutagenic activity after reaction of different foodstuffs with nitrite at acidic pH values, suggesting the presence in these foodstuffs of nitrosatable compounds. Products derived from soya [5,6], broad beans [7], black beans [8], pickles [6], several fishes and smoked or grilled meats [9,10,11,12], tea [5], or wines [13,14] are examples of some food items with genotoxic activity after nitrosation. Secondary amines [15], amino acids [16,17,18], heterocyclic amines [19], biogenic amines like tyramine [6,14], and several phenolic compounds [14] were identified as some of the precursors responsible for the genotoxic activity of various foodstuffs after nitrosation.…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity of instant coffee and of some phenolic compounds present in coffee upon nitrosation

Duarte

Laires

Gaspar

et al. 2000

Teratog. Carcinog. Mutagen.

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Instant coffee exhibits genotoxic activity upon nitrosation at acidic pH values in the Ames tester strain TA100. Using adsorption chromatography (Amberlit XAD-2) it was observed that the major fraction of molecules responsible for the genotoxic activity upon nitrosation was not retained on this resin, suggesting that the polar molecules present in instant coffee could be responsible for the genotoxicity observed upon nitrosation. Some phenolic molecules present in instant coffee (catechol, caffeic acid, and chlorogenic acid) were also genotoxic upon nitrosation under the same experimental conditions. The concentrations of nitrosatable phenolic compounds in the studied coffee were determined by HPLC and their contributions to the total genotoxicity observed were studied. The results obtained suggest that besides phenolic compounds other molecules were also involved in the genotoxicity of this beverage upon nitrosation. Teratogenesis Carcinog. Mutagen. 20:241-249, 2000.

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