Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution

Reinwald, Yvonne; Johal, Ramneek K.; Ghaemmaghami, Amir M.; Rose, Felicity R. A. J.; Howdle, Steven M.; Shakesheff, Kevin M.

doi:10.1016/j.polymer.2013.09.041

Cited by 61 publications

(44 citation statements)

References 61 publications

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“…The data of the permeability, i.e. 11 × 10 −14 to 27 × 10 −14 m 2 , were higher than that of the reported PLGA scaffolds, and were comparable to the two‐layered collagen scaffolds …”

Section: Resultssupporting

confidence: 61%

“…With the increase of β‐TCP content, the permeability (k) of the porous materials first increased and then gradually reduced. The permeability of a porous material was related to its hydrophilicity and porosity . It seems that the porosity of PVA/β‐TCP porous composites played main role, because the changes of the permeability of the composites presented the same change trend as their porosity.…”

Section: Resultsmentioning

confidence: 98%

“…The permeability measurement of the porous material was performed as described in literatures . The porous composite was first cut into a cylinder (with 25 mm diameter, and 3 mm height), then was filled into a self‐made sample chamber, and was sealed to avoid fluid flowing around the samples.…”

Section: Characterizationsmentioning

confidence: 99%

“…So, water could flow through the sample gradually under its static pressure. The hydraulic permeability ( k ) was calculated using Darcy's law

k = (|, Q \times η \times h) / (|, △ P \times A)

where Q is the volumetric flow rate (m 3 /s), which was calculated by the mass of water flowing through the sample within 30 min; η presents the fluid viscosity (Pa s), h is the height (m) of sample, △ P presents the pressure difference across the sample (Pa), which is the static water pressure ( P = ρ gh ) here, and A is the cross‐sectional area (m 2 ) of the sample.…”

Section: Characterizationsmentioning

confidence: 99%

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Effect of β‐tricalcium phosphate on the thermal foaming behavior of poly(vinyl alcohol)/water system

Zhu

Wang

2017

J of Applied Polymer Sci

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Poly(vinyl alcohol) (PVA)/b-tricalcium phosphate (b-TCP, Ca 3 (PO 4 ) 2 ) porous composite, which has potential application in articular cartilage repair, was prepared through thermal foaming using water as both plasticizer and physical blowing agent. The effects of b-TCP content on the foaming behavior, the structure and properties of the porous composites were studied. The results showed that b-TCP could form hydrogen bonds or coordination interaction with PVA and water; with the incorporation of b-TCP, the content of nonfreezable bound water in system increased, the water evaporation reduced, beneficial to the controllable foaming of water. The interactions between PVA-b-TCP led to the enhanced melt viscosity of PVA. Simultaneously, the b-TCP particles in matrix could act as heterogeneous nucleation agent to increase the cell density. When b-TCP content was 7.4 wt %, the porous composite showed the optimal cell structure, i.e., 250 lm average cell size and 87% porosity. The dynamic modulus of the porous composites increased with b-TCP content and showed frequency-dependence. The surface contact angle and permeability of the porous composites varied with b-TCP content, which ranged from 358 to 488 and 11 3 10 214 to 27 3 10 214 m 2 , respectively. V C 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44737.

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Section: Resultssupporting

confidence: 61%

Section: Resultsmentioning

confidence: 98%

Section: Characterizationsmentioning

confidence: 99%

“…So, water could flow through the sample gradually under its static pressure. The hydraulic permeability ( k ) was calculated using Darcy's law

k = (|, Q \times η \times h) / (|, △ P \times A)

Section: Characterizationsmentioning

confidence: 99%

See 2 more Smart Citations

Effect of β‐tricalcium phosphate on the thermal foaming behavior of poly(vinyl alcohol)/water system

Zhu

Wang

2017

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…Bone substitutes act as three-dimensional matrices that guide and promote bone regeneration in order to heal critical sized defects. [1][2][3] In these defects caused by trauma, 4 tumour resection, 4,5 or severe fracture, 5,6 bone is unable to heal itself. The most common bone substitutes include autografts, 7,8 allografts, 8 and xenografts, 8 which are pieces of bone removed from the body of the patient, another person, or an animal, respectively.…”

Section: Introductionmentioning

confidence: 99%