Interconnection Between Cellular Senescence, Regeneration and Ageing in Salamanders

Yu, Qinghao; Yun, Maximina H.

doi:10.1007/978-3-030-44903-2_3

Cited by 2 publications

(2 citation statements)

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“…An increased accumulation of senescent cells could also account for the delay in regeneration from older newts. Senescent cells secrete numerous growth factors, proteases, cytokines, chemokines, and matrix remodeling proteins that can negatively impact several stages of regeneration (Yu and Yun, 2020;Yun, 2021). The importance of clearing senescent cells in mammalian tissues was highlighted by Baker et al, where genetic targeting of senescent cells was shown to alleviate cellular dysfunction caused by aging (Baker et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Regenerative hallmarks of aging: Insights through the lens ofPleurodeles waltl

Tsissios

Theodoroudis-Rapp

Chen

et al. 2022

Preprint

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BackgroundAging and regeneration are heavily linked processes. While it is generally accepted that regenerative capacity declines with age, some vertebrates, such as newts, can bypass the deleterious effects of aging and successfully regenerate a lens throughout their lifetime.ResultsHere, we used Optical Coherence Tomography (OCT) to monitor the lens regeneration process of larvae, juvenile, and adult newts. While all three life stages were able to regenerate a lens through transdifferentiation of the dorsal iris pigment epithelial cells (iPECs), an age-related decline in the kinetics of the regeneration process was observed. Consistent with these findings, iPECs from older animals exhibited a delay in cell cycle re-entry. Furthermore, it was observed that clearance of the extracellular matrix (ECM) was delayed in older organisms.ConclusionsCollectively, our results suggest that although lens regeneration capacity does not decline throughout the lifespan of newts, the intrinsic and extrinsic cellular changes caused by aging alter the kinetics of this process. By understanding how aging affects lens regeneration in newts, we can gain important insights for restoring the age-related regeneration decline observed in most vertebrates.

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Section: Discussionmentioning

confidence: 99%

Regenerative hallmarks of aging: Insights through the lens ofPleurodeles waltl

Tsissios

Theodoroudis-Rapp

Chen

et al. 2022

Preprint

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“…Due to their size and skin mediated compound exchange, salamanders can be used for moderate-throughput screening of pharmaceutical compounds (Ponomareva et al, 2015). * Adapted from Yu and Yun (2020).…”

Section: Introductionmentioning

confidence: 99%

Salamander Insights Into Ageing and Rejuvenation

Yun

2021

Front. Cell Dev. Biol.

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Exhibiting extreme regenerative abilities which extend to complex organs and entire limbs, salamanders have long served as research models for understanding the basis of vertebrate regeneration. Yet these organisms display additional noteworthy traits, namely extraordinary longevity, indefinite regenerative potential and apparent lack of traditional signs of age-related decay or “negligible senescence.” Here, I examine existing studies addressing these features, highlight outstanding questions, and argue that salamanders constitute valuable models for addressing the nature of organismal senescence and the interplay between regeneration and ageing.

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Interconnection Between Cellular Senescence, Regeneration and Ageing in Salamanders

Cited by 2 publications

References 97 publications

Regenerative hallmarks of aging: Insights through the lens ofPleurodeles waltl

Regenerative hallmarks of aging: Insights through the lens ofPleurodeles waltl

Salamander Insights Into Ageing and Rejuvenation

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