Interconnected porous nanofibrous gelatin scaffolds prepared via a combined thermally induced phase separation/particulate leaching method

Sabzi, E; Abbasi, Farhang; Ghaleh, Hakimeh

doi:10.1080/09205063.2020.1845921

Cited by 21 publications

(13 citation statements)

References 34 publications

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“…The implant-based scaffold requires surgical procedure to be applied to the infected bone. They are prepared by several techniques including lyophilization (Nair et al., 2015 ; Narayan et al., 2017 ), solvent casting (Siemann, 2005 ; Choudhury et al., 2015 ), particulate leaching (Phull et al., 2013 ; Sabzi et al., 2021 ) gas foaming (Teng et al., 2007 ; Diaz-Gomez et al., 2017 ), or electrospinning techniques (Frohbergh et al., 2012 ; Su et al., 2012 ). In a study by Zhou et al.…”

Section: Systems Under Investigation For the Local Delivery Of Antibiotic For Osteomyelitis Managementmentioning

confidence: 99%

Recent advances in the local antibiotics delivery systems for management of osteomyelitis

et al. 2021

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Section: Systems Under Investigation For the Local Delivery Of Antibiotic For Osteomyelitis Managementmentioning

confidence: 99%

Recent advances in the local antibiotics delivery systems for management of osteomyelitis

et al. 2021

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“…Moreover, as the polymer concentration increases, pore dimension and porosity decrease accordingly while obtaining a well-interconnected macroporous structure [ 18 ]. The mechanical performances and morphological properties have a significant relationship in the scaffold fabrication process.…”

Section: Phase Separationmentioning

confidence: 99%

“…Luo et al [ 70 ] produced scaffolds with different porosities and microstructures using TIPS to study the relationship between the polymer average molecular weight and tensile strength. In the study of Sabzi et al [ 18 ], desirable mechanical properties and the control over fiber diameter and orientation of nanofibrous gelatin scaffolds were obtained by combining TIPS with the particulate leaching technique. Additionally, Zheng et al [ 71 ] examined the combination of TIPS and particulate leaching to produce 3D nanofibrous scaffolds with well-defined macro and microstructures and the incorporation 5 wt % of 45S5 bioglass particles.…”

Section: Phase Separationmentioning

confidence: 99%

“…Biocompatibility, biodegradability, appropriate mechanical properties, and high surface-to-volume ratio are the main characteristics of materials suitable for TE treatments [ 7 , 8 ]. Generally, the choice of the material for solution-based technologies relies on the desired morphology, function, and application of the produced scaffold, including biopolymers such as polycaprolactone (PCL) [ 9 , 10 ], polylactide (PLA) [ 11 , 12 , 13 ], poly(lactide-co-glycolide; PLGA) [ 14 ], poly(vinyl) alcohol (PVA) [ 15 ], gelatin [ 16 ], chitosan [ 10 ], and collagen [ 17 , 18 ]. According to the expected structural and mechanical performance for tissue replacement, different solution-based fabrication methods could be applied ( Figure 1 ), such as freeze-drying [ 17 , 19 , 20 ] ( Figure 1 a), Thermally or Diffusion Induced Phase Separation (TIPS ( Figure 1 b) or DIPS ( Figure 1 c)) [ 21 , 22 ], electrospinning [ 23 , 24 ] ( Figure 1 d), or a valuable combination of them [ 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Solution-Based Processing for Scaffold Fabrication in Tissue Engineering Applications: A Brief Review

et al. 2021

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The fabrication of 3D scaffolds is under wide investigation in tissue engineering (TE) because of its incessant development of new advanced technologies and the improvement of traditional processes. Currently, scientific and clinical research focuses on scaffold characterization to restore the function of missing or damaged tissues. A key for suitable scaffold production is the guarantee of an interconnected porous structure that allows the cells to grow as in native tissue. The fabrication techniques should meet the appropriate requirements, including feasible reproducibility and time- and cost-effective assets. This is necessary for easy processability, which is associated with the large range of biomaterials supporting the use of fabrication technologies. This paper presents a review of scaffold fabrication methods starting from polymer solutions that provide highly porous structures under controlled process parameters. In this review, general information of solution-based technologies, including freeze-drying, thermally or diffusion induced phase separation (TIPS or DIPS), and electrospinning, are presented, along with an overview of their technological strategies and applications. Furthermore, the differences in the fabricated constructs in terms of pore size and distribution, porosity, morphology, and mechanical and biological properties, are clarified and critically reviewed. Then, the combination of these techniques for obtaining scaffolds is described, offering the advantages of mimicking the unique architecture of tissues and organs that are intrinsically difficult to design.

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“…Biodegradable polymers such as PCL, PLLA, PLGA, etc. are used as scaffolds in tissue engineering to foster cells until they are replaced by the Extracellular Matrix (ECM) [10][11][12]. An ideal scaffold should be extremely porous with linked pores, biodegradable, and made of components that are compatible.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Polycaprolactone/Carboxymethyl Cellulose Scaffolds by Mechanical and Thermal Analysis

Sriputtha¹,

Wiwatwongwana²,

Promma

2022

Eng. Technol. Appl. Sci. Res.

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The objective of this work was to learn more about three-dimensional porous scaffolds made from biomaterial based on polycaprolactone (PCL) containing different amounts of carboxymethyl cellulose (CMC) nanoparticles. Composite material samples containing 0, 2, 6.5, 11, 15.5, and 20% w/w of CMC and PCL/CMC scaffolds were prepared with the use of the salt particle leached technique. The mechanical properties were evaluated with the compressive strength analysis method. The studied temperature range started at very low temperatures and ended at crosslinking temperatures. It was evaluated using the thermal analysis methods of Differential Scanning Calorimetry (DSC) in the range 0ºC-200ºC. The results revealed that the compressive modulus of blended PCL/CMC scaffold was higher than the one of pure PCL scaffold (582.2±106.2 kPa for pure PCL scaffold and 612.2±296 kPa for blended scaffold which contained 20% of CMC). For DSC analysis, in addition to the 15.5% w/w CMC PCL/CMC composite scaffold, other proportions of composite materials showed a decrease in crystallization temperature. The crystallinity of PCL-20% CMC was higher than that of PCL scaffolds.

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Interconnected porous nanofibrous gelatin scaffolds prepared via a combined thermally induced phase separation/particulate leaching method

Cited by 21 publications

References 34 publications

Recent advances in the local antibiotics delivery systems for management of osteomyelitis

Recent advances in the local antibiotics delivery systems for management of osteomyelitis

Solution-Based Processing for Scaffold Fabrication in Tissue Engineering Applications: A Brief Review

Investigation of Polycaprolactone/Carboxymethyl Cellulose Scaffolds by Mechanical and Thermal Analysis

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