Intercomparison of personal and ambient dosimeters in extremely high-dose-rate pulsed photon fields

Zorloni, Gabriele; Ambrožová, Iva; Carbonez, Pierre; Caresana, M.; Ebert, Stephan; Olšovcová, Veronika; Pitzschke, Andreas; Ploc, Ondřej; Pozzi, Fabio; Silari, M.; Trompier, F.; Truneček, Roman; Zelenka, Z.

doi:10.1016/j.radphyschem.2020.108764

Cited by 11 publications

(5 citation statements)

References 11 publications

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“…Theoretical studies indicate the possibility of dose rate effects in OSL and TL materials (Chen and Leung 2001), but experimental studies have shown the opposite. LiF:Mg,Ti TLDs and BeO OSLDs were demonstrated to be dose rate independent at extremely high instantaneous dose rates: up to 4 × 10 9 Gy s −1 for electron beams (Karsch et al 2012) and up to 6 × 10 5 Gy s −1 for photon beams (Zorloni et al 2020). LiF:Mg,Ti has been also used, together with alanine and radiochromic films, to support biological experiments for FLASH radiotherapy (Jorge et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Investigation of TL and OSL detectors in ultra-high dose rate electron beams

et al. 2023

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Objective: This work aims at investigating the response of various thermally stimulated luminescence detectors (TLDs) and optically stimulated luminescence detectors (OSLDs) for dosimetry of ultra-high dose rate electron beams. The study was driven by the challenges of dosimetry at ultra-high dose rates and the importance of dosimetry for FLASH radiotherapy and radiobiology experiments.Approach: Three types of TLDs (LiF:Mg,Ti, LiF:Mg,Cu,P, CaF2:Tm) and one type of OSLD (Al2O3:C) were irradiated in a 15 MeV electron beam with instantaneous dose rates in the (1-324) kGys-1 range. Reference dosimetry was carried out with an integrating current transformer, which was calibrated in absorbed dose to water against a reference ionization chamber. Additionally, dose rate independent BeO OSLDs were employed as a reference. Beam non-uniformity was addressed by using a matrix of TLDs/OSLDsMain results: The investigated TLDs were shown to be dose rate independent within the experimental uncertainties, which take into account the uncertainty of the dosimetry protocol and the irradiation uncertainty.The relative deviation between the TLDs and the reference dose was lower than 4% for all dose rates. A decreasing response with the dose rate was observed for Al2O3:C OSLDs, but still within 10% from the reference dose. Significance: The precision of the investigated luminescence detectors make them suitable for dosimetry of ultra-high dose rate electron beams. Specifically, the dose rate independence of the TLDs can support the investigation of the beam uniformity as a function of the dose rate, which is one of the challenges of the employed beam. Al2O3:C OSLDs provided high precision measurements, but the decreasing response with the dose rate needs to be confirmed by additional experiments.

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Section: Introductionmentioning

confidence: 99%

Investigation of TL and OSL detectors in ultra-high dose rate electron beams

et al. 2023

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“…The energy response is almost flat down to 30 keV 33 . The filter also ensures the role of build-up materials ensuring the electronic equilibrium at least up to 4 MV X rays beam 34 . The dose range of applicability is given from 10 µGy to 10 Gy.…”

Section: Methodsmentioning

confidence: 99%

Inter-laboratory comparison of gene expression biodosimetry for protracted radiation exposures as part of the RENEB and EURADOS WG10 2019 exercise

Abend

Amundson

Badie

et al. 2021

Sci Rep

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Large-scale radiation emergency scenarios involving protracted low dose rate radiation exposure (e.g. a hidden radioactive source in a train) necessitate the development of high throughput methods for providing rapid individual dose estimates. During the RENEB (Running the European Network of Biodosimetry) 2019 exercise, four EDTA-blood samples were exposed to an Iridium-192 source (1.36 TBq, Tech-Ops 880 Sentinal) at varying distances and geometries. This resulted in protracted doses ranging between 0.2 and 2.4 Gy using dose rates of 1.5–40 mGy/min and exposure times of 1 or 2.5 h. Blood samples were exposed in thermo bottles that maintained temperatures between 39 and 27.7 °C. After exposure, EDTA-blood samples were transferred into PAXGene tubes to preserve RNA. RNA was isolated in one laboratory and aliquots of four blinded RNA were sent to another five teams for dose estimation based on gene expression changes. Using an X-ray machine, samples for two calibration curves (first: constant dose rate of 8.3 mGy/min and 0.5–8 h varying exposure times; second: varying dose rates of 0.5–8.3 mGy/min and 4 h exposure time) were generated for distribution. Assays were run in each laboratory according to locally established protocols using either a microarray platform (one team) or quantitative real-time PCR (qRT-PCR, five teams). The qRT-PCR measurements were highly reproducible with coefficient of variation below 15% in ≥ 75% of measurements resulting in reported dose estimates ranging between 0 and 0.5 Gy in all samples and in all laboratories. Up to twofold reductions in RNA copy numbers per degree Celsius relative to 37 °C were observed. However, when irradiating independent samples equivalent to the blinded samples but increasing the combined exposure and incubation time to 4 h at 37 °C, expected gene expression changes corresponding to the absorbed doses were observed. Clearly, time and an optimal temperature of 37 °C must be allowed for the biological response to manifest as gene expression changes prior to running the gene expression assay. In conclusion, dose reconstructions based on gene expression measurements are highly reproducible across different techniques, protocols and laboratories. Even a radiation dose of 0.25 Gy protracted over 4 h (1 mGy/min) can be identified. These results demonstrate the importance of the incubation conditions and time span between radiation exposure and measurements of gene expression changes when using this method in a field exercise or real emergency situation.

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“…Hand-held contamination monitors are available for each experimental hall. Additionally to the active systems described above, optically stimulated luminescence dosimeters (OSL) of beryllium oxide, used for photon dosimetry and successfully tested in pulsed fields [4], are placed throughout the experimental building. Lithium fluorite thermoluminescent dosimeters, instead, are sensitive to thermal neutrons and/or gammas and are used in the experimental halls.…”

Section: Radiation Protection Aspects and Methodologymentioning

confidence: 99%

Radiation Protection at ELI Beamlines: A Unique Laser Driven Accelerator Facility

Cimmino¹,

Horváth²,

Olšovcová³

et al. 2021

Proceedings of 40th International Conference on High Energy Physics — PoS(ICHEP2020)

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The Extreme Light Infrastructure (ELI) Beamlines is a laser driven accelerator facility located in the outskirts of the city of Prague. With its state-of-the-art lasers, it will carry out an ambitious and diverse research program. Activities at ELI Beamlines can be broken down in complementary areas of scientific interest: development and testing of novel technologies for multi-PW laser systems, plasma physics, high field physics experiments, production of femtosecond secondary sources of ionizing radiation (extreme ultraviolet radiation, X rays, gamma, electrons, and protons) to be used in interdisciplinary applications in physics, biology, medicine, and material sciences. In-house experiments are already taking place since the first half of 2018, first user calls and experiments started in 2019. In this contribution, the ELI Beamlines accelerator facility and its current status of operation are presented in more details. Particular attention is paid to the design and implementation of the radiation protection program, with emphasis on the unique challenges this laser facility poses in terms of radiation safety.

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Intercomparison of personal and ambient dosimeters in extremely high-dose-rate pulsed photon fields

Cited by 11 publications

References 11 publications

Investigation of TL and OSL detectors in ultra-high dose rate electron beams

Investigation of TL and OSL detectors in ultra-high dose rate electron beams

Inter-laboratory comparison of gene expression biodosimetry for protracted radiation exposures as part of the RENEB and EURADOS WG10 2019 exercise

Radiation Protection at ELI Beamlines: A Unique Laser Driven Accelerator Facility

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