Intercomparison of DCA and EPR scoring for validation with individual physical dosimetry

Abstract

Radiation is widely used in industrial, medical, agricultural, and military applications. The improper use and disposal of manmade radiation sources have resulted in various events that have caused different levels of human radiation exposure. These experiences indicate that estimating only the amount of radioactive contamination and dose after an incident was not sufficient to realize in detail and determine the exact exposure dose owing to the incident. Therefore, a retrospective assessment of radiation exposure and dose reconstruction is a necessary and crucial method for risk analysis. In this studies, we used one healthy volunteer peripheral blood and fingernail samples for the project were irradiated with 0–5 and 0–20 Gy Co-60 irradiation for establish a dose-dependent curve with DCA and EPR dose-response curve assays, respectively. Further, another 20 volunteers participated in this clinical trial; their DCA and EPR scores were calculated, and followed by an evaluation of their equivalent radiation doses and corresponded with their monthly physical dosimetry. Through this study, we established the dose-response curve of DCA and EPR after radiation exposure, and calculated the correlation between physical dosimetry and biological doses by 20 volunteers participating in clinical trials. This evidence will promote estimating the personal absorbed doses and as a reference for medical treatment for the safety of radiation workers and normal populations.