Interchromosomal Telomere Length Variation

Suda, Takafumi; Fujiyama, Asao; Takimoto, Mitsuhiro; Igarashi, Masato; Kuroiwa, Takashi; Waguri, Nobuo; Kawai, Hirokazu; Mita, Yusaku; Aoyagi, Yoshinobu

doi:10.1006/bbrc.2002.6425

Cited by 12 publications

(13 citation statements)

References 21 publications

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“…Several studies have found statistically significant correlations of telomere length to the total size of each chromosome (summation of p and q arms) [5]–[8], [12]. We observed a similar correlation with our data (not shown) (p<0.0001).…”

Section: Discussionsupporting

confidence: 92%

Human Telomere Length Correlates to the Size of the Associated Chromosome Arm

et al. 2009

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The majority of human telomere length studies have focused on the overall length of telomeres within a cell. In fact, very few studies have examined telomere length for individual chromosome arms. The objective of this study was to examine the relationship between chromosome arm size and the relative length of the associated telomere. Quantitative Fluorescence In Situ Hybridization (Q-FISH) was used to measure the relative telomere length of each chromosome arm in metaphases from cultured lymphocytes of 17 individuals. A statistically significant positive correlation (r = 0.6) was found between telomere length and the size of the associated chromosome arm, which was estimated based on megabase pair measurements from http://www.ncbi.nlm.nih.gov/projects/mapview/.

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Section: Discussionsupporting

confidence: 92%

Human Telomere Length Correlates to the Size of the Associated Chromosome Arm

et al. 2009

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“…The expected relationship of longer telomeres occurring alongside greater mean chromosome size was also not observed interspecifically within the orders Rodentia or Primates, where the strongest evidence for correlations between these traits exists at the intraspecific level [ 3 , 6 – 12 ]. Neither did the relationship exist within the third order analysed, Cetartiodactyla.…”

Section: Discussionmentioning

confidence: 99%

“…The fine-scale specificity of TL at the level of chromosome arms suggests a great deal of telomere biology and patterns of variation in TL could be masked by only considering mean TL. Hinting at important TL dynamics, several human studies from independent laboratories have observed a consistent, positive linear relationship ( r = 0.6–0.76) between whole chromosome size and TL on individual chromosomes [ 6 – 8 ]. Similar associations exist between TL and individual chromosome arm length across chromosomes ( r = 0.57–0.79) [ 3 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Mammalian chromosome–telomere length dynamics

Klegarth

Eisenberg

2018

R. Soc. open sci.

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Individual chromosome arms have specific individual telomere lengths (TLs). Past studies within species have shown strong positive correlations between individual chromosome length and TL at that chromosome. While the reasons for these associations are unclear, the strength and consistency of the associations across disparate taxa suggest that this is important to telomere biology and should be explored further. If TL is primarily determined by chromosome length, then chromosome length should be considered and controlled for in cross-species analyses of TL. Here, we employ a cross-species approach to explore whether the chromosome length–TL association observed intraspecifically is a determinant of mean TL across species. Data were compiled from two studies characterizing TL across a range of mammalian taxa and analysed in a phylogenetic framework. We found no significant relationship between TL and chromosome size across mammals or within mammalians orders. The pattern trends in the expected direction and we suggest may be masked by evolutionary lag effects.

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“…Although there is a general correlation between chromosome size and telomere length (Suda et al, 2002), the fact that there is variation between maternal and paternal telomere length on any given chromosome (Londono-Vallejo et al, 2001) suggests that the control of telomere length in the germline is imprecise. A 3-kb variation in size between a 15-kb maternal and an 18-kb paternal telomere would make little difference in the germline, but would make an enormous difference in which specific telomere became limiting when shortening reduced the respective lengths to 0.5 and 3.5 kb.…”

Section: Discussionmentioning

confidence: 99%

Does a Sentinel or a Subset of Short Telomeres Determine Replicative Senescence?

Zou

Sfeir

Gryaznov

et al. 2004

MBoC

267

227

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The proliferative life span of human cells is limited by telomere shortening, but the specific telomeres responsible for determining the onset of senescence have not been adequately determined. We here identify the shortest telomeres by the frequency of signal-free ends after in situ hybridization with telomeric probes and demonstrate that probes adjacent to the shortest ends colocalize with gammaH2AX-positive DNA damage foci in senescent cells. Normal BJ cells growth arrest at senescence before developing significant karyotypic abnormalities. We also identify all of the telomeres involved in end-associations in BJ fibroblasts whose cell-cycle arrest at the time of replicative senescence has been blocked and demonstrate that the 10% of the telomeres with the shortest ends are involved in >90% of all end-associations. The failure to find telomeric end-associations in near-senescent normal BJ metaphases, the presence of signal-free ends in 90% of near-senescent metaphases, and the colocalization of short telomeres with DNA damage foci in senescent interphase cells suggests that end-associations rather than damage signals from short telomeres per se may be the proximate cause of growth arrest. These results demonstrate that a specific group of chromosomes with the shortest telomeres rather than either all or only one or two sentinel telomeres is responsible for the induction of replicative senescence.

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Interchromosomal Telomere Length Variation

Cited by 12 publications

References 21 publications

Human Telomere Length Correlates to the Size of the Associated Chromosome Arm

Human Telomere Length Correlates to the Size of the Associated Chromosome Arm

Mammalian chromosome–telomere length dynamics

Does a Sentinel or a Subset of Short Telomeres Determine Replicative Senescence?

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